Potent antioxidant and genotoxic effects of ammonium tetraborate in vitro

Year 2015, Volume: 1 Issue: 2, 45 - 9, 30.06.2015

Fatih Celikezen , Hasan Turkez , Elanur Aydin , Mehmet Izgi , Burcin Celikezen

https://doi.org/10.20863/nsd.06412

Cited By: 4

Abstract

Aim: Boron shows antioxidant properties with an unknown mechanism. It was aimed to evaluate the antioxidant potentials and genotoxic risk of ammonium tetraborate on human whole blood cultures for the first time in the extent of this study (n=4).

Material and Methods: Ammonium tetraborate was administrated at concentrations between 1,25- 1280 µg/ml to cultured blood samples. The micronuclei and chromosomal aberration tests were performed to determine genotoxic effect. In addition, total antioxidant capacity and total oxidative stress levels were measured as biochemical parameters.

Results: Our results clearly provded that the all tested concentrations of ammonium tetraborate were not-mutagenic. Moreover, ammonium tetraborate showed antioxidant activities at low concentrations and the total oxidative stress levels were not changed at all the concentrations of ammonium tetraborate.

Conclusion: our data clearly indicated that ammonium tetraborate is not mutagenic and it has remerkable antioxidant potential in vitro.

Keywords

Ammonium tetraborate, Chromosomal aberrations, micronucleus test, genotoxicity, human blood cells

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