Clinicopathological Characteristics of Endometrial Carcinosarcomas: A Single-Center Experience

Year 2021, Volume: 2 Issue: 1, 39 - 44, 25.01.2021

Onur Ceylan , Sevilay Özmen

Abstract

Endometrial carcinosarcoma (ECS) is epidemiologically and clinically similar to endometrial adenocarcinoma and is considered an aggressive variant. Considered as carcinomas with sarcomatous and carcinomatous components, these tumors are rare, with a very poor prognosis. The definitive diagnosis of ECS is based on histopathological examination. Here, we aimed to share the clinicopathological characteristics of histopathologically diagnosed ECS cases. We analyzed 26 materials diagnosed with ECS after necessary histopathological examinations that were sent to our department as total abdominal hysterectomy in the last 7 years. The histological carcinoma component was serous carcinoma in 14 cases and endometrioid adenocarcinoma in 12. The histological sarcoma component was endometrial stromal sarcoma in 16 cases, fibrosarcoma in 2, leiomyosarcoma in 2, and chondrosarcoma in 6. According to FIGO staging, 10 of the cases were stage IA, 2 was stage IB, 2 was stage IIIA, 10 were stage IIIC2, and 2 was stage IVB. According to pTNM pathological staging, 10 of the cases were pT1a, 6 were pT1b, 4 were pT3a, 4 were pT3b, and 2 was pT4. Since the sarcomatous component of ECS is unlikely to metastasize, the prognosis is believed to be shaped by the characteristics of the epithelial component. Consistent with the literature, we found all lymph node and distant organ metastases to be consisted of carcinomatous components. Currently, there is no typical laboratory finding or specific imaging for the definitive diagnosis of ECS, so it is based solely on histopathological examination. Accordingly, both FIGO and pTNM staging can be performed following histopathological examination by the appropriate procedure.

Keywords

Endometrial carcinosarcoma, Malignant mixed mullerian tumor, Histopathology

Supporting Institution

NA

Project Number

NA

Thanks

NA

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