Association of gamma-glutamyl transpherase activity with electrocardiographic indicators in coronary artery disease patients

Year 2017, Volume: 34 Issue: 4, 235 - 240, 10.10.2019

Murat Meric , Metin Çoksevim Sabri Demircan Korhan Soylu Serkan Yuksel

Abstract

Gamma-glutamyl transpherase (GGT) plays an important role in atherogenesis
through its activity in oxidative processes, which has been demonstrated in clinical
studies. The connection between serum GGT activity and noninvasive
arrhythmia indicators in patients with coronary artery disease (CAD) is investigated
in the present study. We examined patients (n = 254, 174 males, mean age 62 ± 8) diagnosed with coronary
artery disease on the basis of clinical and angiographic findings. All patient
data were assessed, including serum GGT activity, biochemical measurements, and
demographic and electrocardiographic features. A
positive correlation was found between GGT levels and P-wave dispersion (r = 0.299,
p < 0.0001); however, there was a negative correlation between GGT and
ejection fraction (r = 0.216, p < 0.001). On the other hand, no correlation
was found between GGT and the following: Sokolow-Lyon voltage, Cornell voltage,
Cornell product, corrected QT, and QT dispersion (p values are 0.728, 0.892,
0.551, 0.069, and 0.146, respectively). When the patients were grouped according
to gender, a significant association of GGT with P-wave dispersion and ejection
fraction was observed in both of the groups. Nonetheless, a significant
correlation between GGT and QTc was only found in the female group. In this study, we found that increased GGT activity was correlated with P-wave
dispersion. These results indicate that there might be an increased risk of
arrhythmias especially the atrial fibrillation in this patient population.

Keywords

Gamma-glutamyl transpherase, Atherosclerosis, P-wave dispersion, Coronary Artery Disease, Arrhythmias

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