Importance of atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion (ASC-H)

Year 2019, Volume: 36 Issue: 4, 113 - 119, 02.03.2020

Murat Alan , Muhammet Ali Oruç Yasemin Alan , Hakkı Aytaç Duygu Ayaz , Volkan Karataşlı Muzaffer Sancı

Abstract

In this study, we evaluated the biopsy counterparts of atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H) cases. This was a cross-sectional, retrospective study on ASC-H cases. The follow-up results of ASC-H cases diagnosed during routine primary screening between 2011 and 2018 were evaluated, and the relationship between clinicopathological parameters, high risk Human Papilloma Virus (hrHPV) test and patients’ ages at diagnosis were evaluated. Among one hundred sixty-nine ASC-H patients, high grade squamous intraepithelial lesion (HSIL) was detected in 56 (33.1%), low grade squamous intraepithelial lesion (LSIL) in 59 (35%), squamous cell carcinoma in 5 (3%) and adenocarcinoma in 1 (0.5%). HPV 16 was detected in 41 (24.4%) cases and HPV 18 in 26 (16%) cases, and 51 patients had low risk of HPV (lrHPV). The mean age of the patients with hrHPV was 31.78 ± 8.22, and the mean age of the patients with lrHPV was 34.77 ± 5.47. HPV positivity in ASC-H smears was significantly correlated with age (p = 0.004). General linear regression analysis showed that biopsy results were significantly correlated with HPV in high-risk patients compared to low-risk patients. hrHPV evaluation in ASC-H follow-up is significant for cervical premalignant lesion. A management strategy that requires close monitoring in women with ASCH and under 40 years old, especially in association with hrHPV, should be considered.

Keywords

ASC-H, Cervical Premalign Lesion, Histopathology, HPV

References

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