Research Article
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Year 2021, Volume: 38 Issue: 2, 111 - 114, 03.04.2021

Abstract

References

  • Aruga, J. (2004). The role of Zic genes in neural development. Mol Cell Neurosci, 26(2), 205-221. doi: 10.1016/j.mcn.2004.01.004
  • Bhatnagar, S., & Taneja, S. (2001). Zinc and cognitive development. Br J Nutr, 85 Suppl 2, S139-145. doi: 10.1079/bjn2000306
  • Chowanadisai, W., Graham, D. M., Keen, C. L., Rucker, R. B., & Messerli, M. A. (2013). A zinc transporter gene required for development of the nervous system. Commun Integr Biol, 6(6), e26207. doi: 10.4161/cib.26207
  • Cumming, T. B., Churilov, L., Linden, T., & Bernhardt, J. (2013). Montreal Cognitive Assessment and Mini-Mental State Examination are both valid cognitive tools in stroke. Acta Neurol Scand, 128(2), 122-129. doi: 10.1111/ane.12084
  • Falkingham, M., Abdelhamid, A., Curtis, P., Fairweather-Tait, S., Dye, L., & Hooper, L. (2010). The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis. Nutr J, 9, 4. doi: 10.1186/1475-2891-9-4
  • Grabrucker, S., Boeckers, T. M., & Grabrucker, A. M. (2016). Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency. Front Behav Neurosci, 10, 37. doi: 10.3389/fnbeh.2016.00037
  • Hershko, C., & Camaschella, C. (2014). How I treat unexplained refractory iron deficiency anemia. Blood, 123(3), 326-333. doi: 10.1182/blood-2013-10-512624
  • Jiang, Y. G., Fang, H. Y., Pang, W., Liu, J., Lu, H., Ma, Q., & Fang, H. T. (2011). Depressed hippocampal MEK/ERK phosphorylation correlates with impaired cognitive and synaptic function in zinc-deficient rats. Nutr Neurosci, 14(2), 45-50. doi: 10.1179/1476830510Y.0000000002
  • Lozoff, B., & Georgieff, M. K. (2006). Iron deficiency and brain development. Semin Pediatr Neurol, 13(3), 158-165. doi: 10.1016/j.spen.2006.08.004
  • Markiewicz-Zukowska, R., Gutowska, A., & Borawska, M. H. (2015). Serum zinc concentrations correlate with mental and physical status of nursing home residents. PLoS One, 10(1), e0117257. doi: 10.1371/journal.pone.0117257
  • Maylor, E. A., Simpson, E. E., Secker, D. L., Meunier, N., Andriollo-Sanchez, M., Polito, A., . . . Coudray, C. (2006). Effects of zinc supplementation on cognitive function in healthy middle-aged and older adults: the ZENITH study. Br J Nutr, 96(4), 752-760.
  • Nasreddine, Z. S., Phillips, N. A., Bedirian, V., Charbonneau, S., Whitehead, V., Collin, I., . . . Chertkow, H. (2005). The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc, 53(4), 695-699. doi: 10.1111/j.1532-5415.2005.53221.x
  • Petersen, R. C. (2011). Clinical practice. Mild cognitive impairment. N Engl J Med, 364(23), 2227-2234. doi: 10.1056/NEJMcp0910237
  • Pfaender, S., Fohr, K., Lutz, A. K., Putz, S., Achberger, K., Linta, L., . . . Grabrucker, A. M. (2016). Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells. Neural Plast, 2016, 3760702. doi: 10.1155/2016/3760702
  • Selekler K,Cangöz B,Uluç S. (2010) Montreal bilişsel değerlendirme ölçeği (MOBİD)'nin hafif bilişsel bozukluk ve alzheımer hastalarını ayırt edebilme gücünün incelenmesi. Türk Geriatri Dergisi. 2010; 13(3): 166 - 171.
  • Tan, J. P., Wang, L. N., & Wang, W. (2006). [A case-control study of risk factors in mild cognitive impairment]. Zhonghua Liu Xing Bing Xue Za Zhi, 27(1), 55-57.

Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia

Year 2021, Volume: 38 Issue: 2, 111 - 114, 03.04.2021

Abstract

Background
Iron deficiency and zinc deficiency had been known to disturb congnitive functions especially in infants and preschool children. Our purpose was to evaluate the effect of zinc deficiency and iron deficiency on cognitive function (with Montreal Cognitive Assesment [MoCA] score) in females.
Methods:
We designed a randomized controlled prospective study. 41 iron deficient female patients and 40 healthy volunteers were involved in the study
Results:
The average MoCA score ± SD was 24,63 ± 4,3 (range 11–30) in ıron deficiency anemia (IDA), and 27.43± 2.02 (23-30) in healthy volunteers. Zinc level was 97.06 (40.8–146.8) mg/dl and 257.5 (128.2–463.7) in IDA and healthy volunteers respectively. MoCA score (r= 0.803, p=0,000<0,01), were significantly correlated with Zinc Level in iron deficient group.
Conclusion:
We found that there was a statistically important linear relationship between MoCA score and zinc level in female patinets with iron defciency anemia.

References

  • Aruga, J. (2004). The role of Zic genes in neural development. Mol Cell Neurosci, 26(2), 205-221. doi: 10.1016/j.mcn.2004.01.004
  • Bhatnagar, S., & Taneja, S. (2001). Zinc and cognitive development. Br J Nutr, 85 Suppl 2, S139-145. doi: 10.1079/bjn2000306
  • Chowanadisai, W., Graham, D. M., Keen, C. L., Rucker, R. B., & Messerli, M. A. (2013). A zinc transporter gene required for development of the nervous system. Commun Integr Biol, 6(6), e26207. doi: 10.4161/cib.26207
  • Cumming, T. B., Churilov, L., Linden, T., & Bernhardt, J. (2013). Montreal Cognitive Assessment and Mini-Mental State Examination are both valid cognitive tools in stroke. Acta Neurol Scand, 128(2), 122-129. doi: 10.1111/ane.12084
  • Falkingham, M., Abdelhamid, A., Curtis, P., Fairweather-Tait, S., Dye, L., & Hooper, L. (2010). The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis. Nutr J, 9, 4. doi: 10.1186/1475-2891-9-4
  • Grabrucker, S., Boeckers, T. M., & Grabrucker, A. M. (2016). Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency. Front Behav Neurosci, 10, 37. doi: 10.3389/fnbeh.2016.00037
  • Hershko, C., & Camaschella, C. (2014). How I treat unexplained refractory iron deficiency anemia. Blood, 123(3), 326-333. doi: 10.1182/blood-2013-10-512624
  • Jiang, Y. G., Fang, H. Y., Pang, W., Liu, J., Lu, H., Ma, Q., & Fang, H. T. (2011). Depressed hippocampal MEK/ERK phosphorylation correlates with impaired cognitive and synaptic function in zinc-deficient rats. Nutr Neurosci, 14(2), 45-50. doi: 10.1179/1476830510Y.0000000002
  • Lozoff, B., & Georgieff, M. K. (2006). Iron deficiency and brain development. Semin Pediatr Neurol, 13(3), 158-165. doi: 10.1016/j.spen.2006.08.004
  • Markiewicz-Zukowska, R., Gutowska, A., & Borawska, M. H. (2015). Serum zinc concentrations correlate with mental and physical status of nursing home residents. PLoS One, 10(1), e0117257. doi: 10.1371/journal.pone.0117257
  • Maylor, E. A., Simpson, E. E., Secker, D. L., Meunier, N., Andriollo-Sanchez, M., Polito, A., . . . Coudray, C. (2006). Effects of zinc supplementation on cognitive function in healthy middle-aged and older adults: the ZENITH study. Br J Nutr, 96(4), 752-760.
  • Nasreddine, Z. S., Phillips, N. A., Bedirian, V., Charbonneau, S., Whitehead, V., Collin, I., . . . Chertkow, H. (2005). The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc, 53(4), 695-699. doi: 10.1111/j.1532-5415.2005.53221.x
  • Petersen, R. C. (2011). Clinical practice. Mild cognitive impairment. N Engl J Med, 364(23), 2227-2234. doi: 10.1056/NEJMcp0910237
  • Pfaender, S., Fohr, K., Lutz, A. K., Putz, S., Achberger, K., Linta, L., . . . Grabrucker, A. M. (2016). Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells. Neural Plast, 2016, 3760702. doi: 10.1155/2016/3760702
  • Selekler K,Cangöz B,Uluç S. (2010) Montreal bilişsel değerlendirme ölçeği (MOBİD)'nin hafif bilişsel bozukluk ve alzheımer hastalarını ayırt edebilme gücünün incelenmesi. Türk Geriatri Dergisi. 2010; 13(3): 166 - 171.
  • Tan, J. P., Wang, L. N., & Wang, W. (2006). [A case-control study of risk factors in mild cognitive impairment]. Zhonghua Liu Xing Bing Xue Za Zhi, 27(1), 55-57.
There are 16 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Clinical Research
Authors

Nevin Alayvaz Aslan 0000-0003-3292-8519

Engin Kelkitli 0000-0001-7342-1760

Nurinnisa Öztürk 0000-0002-7746-2700

Publication Date April 3, 2021
Submission Date November 7, 2020
Acceptance Date November 11, 2020
Published in Issue Year 2021 Volume: 38 Issue: 2

Cite

APA Alayvaz Aslan, N., Kelkitli, E., & Öztürk, N. (2021). Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia. Journal of Experimental and Clinical Medicine, 38(2), 111-114.
AMA Alayvaz Aslan N, Kelkitli E, Öztürk N. Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia. J. Exp. Clin. Med. April 2021;38(2):111-114.
Chicago Alayvaz Aslan, Nevin, Engin Kelkitli, and Nurinnisa Öztürk. “Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia”. Journal of Experimental and Clinical Medicine 38, no. 2 (April 2021): 111-14.
EndNote Alayvaz Aslan N, Kelkitli E, Öztürk N (April 1, 2021) Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia. Journal of Experimental and Clinical Medicine 38 2 111–114.
IEEE N. Alayvaz Aslan, E. Kelkitli, and N. Öztürk, “Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia”, J. Exp. Clin. Med., vol. 38, no. 2, pp. 111–114, 2021.
ISNAD Alayvaz Aslan, Nevin et al. “Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia”. Journal of Experimental and Clinical Medicine 38/2 (April 2021), 111-114.
JAMA Alayvaz Aslan N, Kelkitli E, Öztürk N. Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia. J. Exp. Clin. Med. 2021;38:111–114.
MLA Alayvaz Aslan, Nevin et al. “Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia”. Journal of Experimental and Clinical Medicine, vol. 38, no. 2, 2021, pp. 111-4.
Vancouver Alayvaz Aslan N, Kelkitli E, Öztürk N. Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia. J. Exp. Clin. Med. 2021;38(2):111-4.