Research Article
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Year 2021, Volume: 38 Issue: 3, 255 - 259, 01.05.2021

Abstract

References

  • Adelman, R. D., Tmanova, L. L., Delgado, D., Dion, S., & Lachs, M. S., 2014. Caregiver burden: A clinical review. JAMA. 311, 1052-1060.
  • Alzheimer’s Association, Thies, W., & Bleiler, L., 2013. 2013 Alzheimer’s disease facts and figures. Alzheimers Dement. 9, 208-245.
  • Ar, Y. & Karanci, A. N., 2019. Turkish adult children as caregivers of parents with Alzheimer’s disease: Perceptions and caregiving experiences. Dementia (London). 18, 882-902.
  • Azarpazhooh, M. R., Amiri, A., Morovatdar, N., Steinwender, S., Rezaei Ardani, A., Yassi, N., Biller, J., Stranges, S., Tokazebani Belasi, M., Neya, S. K., Khorram, B., Sheikh Andalibi, M. S., Arsang-Jang, S., Mokhber, N., & Di Napoli, M. , 2020. Correlations between COVID-19 and burden of dementia: An ecological study and review of literature. J Neurol Sci. 416, 117013.
  • Boutoleau-Bretonnière, C., Pouclet-Courtemanche, H., Gillet, A., Bernard, A., Deruet, A. L., Gouraud, I., Mazoue, A., Lamy, E., Rocher, L., Kapogiannis, D., & El Haj, M., 2020. The effects of confinement on neuropsychiatric symptoms in Alzheimer’s disease during the COVID-19 crisis. J Alzheimers Dis. 76, 41-47.
  • Choi E. P. H., Hui B. P. H., & Wan E. Y. F., 2020. Depression and anxiety in Hong Kong during COVID-19. Int J Environ Res Public Health. 17:3740.
  • Cuffaro, L., Di Lorenzo, F., Bonavita, S., Tedeschi, G., Leocani, L., & Lavorgna, L., 2020. Dementia care and COVID-19 pandemic: A necessary digital revolution. Neurol Sci. 41, 1977-1979.
  • Du, R. H, Liang, L. R., Yang, C. Q., Wang, W., Cao, T. Z., Li, M., Guo, G. Y., Du, J., Zheng, C. L, Zhu, Q., Hu, M., Li, X. Y , Peng, P., & Shi, H. Z., 2020. Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: A prospective cohort study. Eur Respir J. 55:2000524.
  • Germain, S., Adam, S., Olivier, C., Cash, H., Ousset, P. J., Andrieu, S., Vellas, B., Meulemans, T., Reynish, E., & Salmon, E., ICTUS-EADC Network., 2009. Does cognitive impairment influence burden in caregivers of patients with Alzheimer’s disease? J Alzheimers Dis. 17, 105-114.
  • Hoffmann, K., Sobol, N. A., Frederiksen, K. S., Beyer, N., Vogel, A., Vestergaard, K., Brændgaard, H., Gottrup, H., Lolk, A., Wermuth, L., Jacobsen, S., Laugesen, L. P., Gergelyffy, R. G., Høgh, P., Bjerregaard, E., Andersen, B. B., Siersma, V., Johannsen, P., Cotman, C. W., Waldemar, G., & Hasselbalch, S. G. , 2016. Moderate-to-high intensity physical exercise in patients with Alzheimer’s disease: A randomized controlled trial. J Alzheimers Dis. 50, 443-53.
  • Isik, A. T., Soysal, P., Solmi, M., & Veronese, N., 2019. Bidirectional relationship between caregiver burden and neuropsychiatric symptoms in patients with Alzheimer’s disease: A narrative review. Int J Geriatr Psychiatry. 34, 1326-1334.
  • Jia, R. X., Liang, J. .H, Xu, Y., & Wang, Y. Q. , 2019. Effects of physical activity and exercise on the cognitive function of patients with Alzheimer disease: a meta-analysis. BMC Geriatr. 19, 181.
  • Lara, B., Carnes, A., Dakterzada, F., Benitez, I., & Piñol-Ripoll, G., 2020. Neuropsychiatric symptoms and quality of life in Spanish Alzheimer’s disease patients during COVID-19 lockdown. Eur J Neurol. 10.1111/ene.14339.
  • Li, X., Xu, S., Yu, M., Wang, K., Tao, Y., Zhou, Y., Shi, J., Zhou, M., Wu, B., Yang, Z., Zhang, C., Yue, J., Zhang, Z., Renz, H., Liu, X., Xie, J., Xie, M., & Zhao, J., 2020. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J Allergy Clin Immunol. 146, 110-118.
  • Ozamiz-Etxebarria, N., Dosil-Santamaria, M., Picaza-Gorrochategui, M., & Idoiaga-Mondragon, N., 2020. Stress, anxiety, and depression levels in the initial stage of the COVID-19 outbreak in a population sample in the northern Spain. Cad Saude Publica. 36, e00054020.
  • Özdin, S., & Bayrak Özdin, Ş., 2020. Levels and predictors of anxiety, depression and health anxiety during COVID-19 pandemic in Turkish society: The importance of gender. Int J Soc Psychiatry. 66, 504-511.
  • Peters, M. E., Schwartz, S., Han, D., Rabins, P. V., Steinberg, M., Tschanz, J. T., & Lyketsos, C. G., 2015. Neuropsychiatric symptoms as predictors of progression to severe Alzheimer’s dementia and death: The Cache County Dementia Progression Study. Am J Psychiatry, 172, 460-465.
  • Truzzi, A., Valente, L., Ulstein, I., Engelhardt, E., Laks, J., & Engedal, K., 2012. Burnout in familial caregivers of patients with dementia. Braz J Psychiatry. 34, 405-412.
  • Yıldızhan, E., Ören, N., Erdoğan, A., & Bal, F., 2019. The burden of care and burnout in individuals caring for patients with Alzheimer’s disease. Community Ment Health J. 55, 304-310.
  • Yu, H., Wang, X., He, R., Liang, R., & Zhou, L., 2015. Measuring the caregiver burden of caring for community-residing people with Alzheimer’s disease. PLoS One. 10, e0132168.

Clinical Deterioration of Alzheimer’s Disease Patients During the COVID-19 Pandemic and Caregiver Burden

Year 2021, Volume: 38 Issue: 3, 255 - 259, 01.05.2021

Abstract

Objectives: To investigate a possible deterioration of the symptoms of Alzheimer’s disease (AD) patients during a quarantine period of 60 days, and the impact on caregiver burden.
Methods: This study consisted of 54 individuals (36 female, 18 male) aged 60 years and over who had been diagnosed with AD. During the quarantine period, caregivers of the patients (child, spouse, relatives) who were confined to their homes were contacted by phone and administered a survey composed of questions for neuropsychiatric symptoms and caregiver burden.
Results: Patients’ mean age was 77.18±6.96 years. The most worsening symptom was forgetfulness (35.2%) and agitation (24.1%). Incoherent speech, introversion, sleep disturbance, hallucinations, carry on with hobbies, reduced personal care, changes in appetite, and incontinence were less deteriorated. Of the caregivers, 61.1% thought that something terrible would happen to the patient, and 38.9% felt they could not find time for themselves. Drug rejection increased the burden twofold.
Conclusion: Telemedicine methods, providing oppurtunities for the caregiver and the patient to walk outside, and giving medication that dissolves in the mouth or epidermal patches may be useful to prevent disease progression during the lockdown.

References

  • Adelman, R. D., Tmanova, L. L., Delgado, D., Dion, S., & Lachs, M. S., 2014. Caregiver burden: A clinical review. JAMA. 311, 1052-1060.
  • Alzheimer’s Association, Thies, W., & Bleiler, L., 2013. 2013 Alzheimer’s disease facts and figures. Alzheimers Dement. 9, 208-245.
  • Ar, Y. & Karanci, A. N., 2019. Turkish adult children as caregivers of parents with Alzheimer’s disease: Perceptions and caregiving experiences. Dementia (London). 18, 882-902.
  • Azarpazhooh, M. R., Amiri, A., Morovatdar, N., Steinwender, S., Rezaei Ardani, A., Yassi, N., Biller, J., Stranges, S., Tokazebani Belasi, M., Neya, S. K., Khorram, B., Sheikh Andalibi, M. S., Arsang-Jang, S., Mokhber, N., & Di Napoli, M. , 2020. Correlations between COVID-19 and burden of dementia: An ecological study and review of literature. J Neurol Sci. 416, 117013.
  • Boutoleau-Bretonnière, C., Pouclet-Courtemanche, H., Gillet, A., Bernard, A., Deruet, A. L., Gouraud, I., Mazoue, A., Lamy, E., Rocher, L., Kapogiannis, D., & El Haj, M., 2020. The effects of confinement on neuropsychiatric symptoms in Alzheimer’s disease during the COVID-19 crisis. J Alzheimers Dis. 76, 41-47.
  • Choi E. P. H., Hui B. P. H., & Wan E. Y. F., 2020. Depression and anxiety in Hong Kong during COVID-19. Int J Environ Res Public Health. 17:3740.
  • Cuffaro, L., Di Lorenzo, F., Bonavita, S., Tedeschi, G., Leocani, L., & Lavorgna, L., 2020. Dementia care and COVID-19 pandemic: A necessary digital revolution. Neurol Sci. 41, 1977-1979.
  • Du, R. H, Liang, L. R., Yang, C. Q., Wang, W., Cao, T. Z., Li, M., Guo, G. Y., Du, J., Zheng, C. L, Zhu, Q., Hu, M., Li, X. Y , Peng, P., & Shi, H. Z., 2020. Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: A prospective cohort study. Eur Respir J. 55:2000524.
  • Germain, S., Adam, S., Olivier, C., Cash, H., Ousset, P. J., Andrieu, S., Vellas, B., Meulemans, T., Reynish, E., & Salmon, E., ICTUS-EADC Network., 2009. Does cognitive impairment influence burden in caregivers of patients with Alzheimer’s disease? J Alzheimers Dis. 17, 105-114.
  • Hoffmann, K., Sobol, N. A., Frederiksen, K. S., Beyer, N., Vogel, A., Vestergaard, K., Brændgaard, H., Gottrup, H., Lolk, A., Wermuth, L., Jacobsen, S., Laugesen, L. P., Gergelyffy, R. G., Høgh, P., Bjerregaard, E., Andersen, B. B., Siersma, V., Johannsen, P., Cotman, C. W., Waldemar, G., & Hasselbalch, S. G. , 2016. Moderate-to-high intensity physical exercise in patients with Alzheimer’s disease: A randomized controlled trial. J Alzheimers Dis. 50, 443-53.
  • Isik, A. T., Soysal, P., Solmi, M., & Veronese, N., 2019. Bidirectional relationship between caregiver burden and neuropsychiatric symptoms in patients with Alzheimer’s disease: A narrative review. Int J Geriatr Psychiatry. 34, 1326-1334.
  • Jia, R. X., Liang, J. .H, Xu, Y., & Wang, Y. Q. , 2019. Effects of physical activity and exercise on the cognitive function of patients with Alzheimer disease: a meta-analysis. BMC Geriatr. 19, 181.
  • Lara, B., Carnes, A., Dakterzada, F., Benitez, I., & Piñol-Ripoll, G., 2020. Neuropsychiatric symptoms and quality of life in Spanish Alzheimer’s disease patients during COVID-19 lockdown. Eur J Neurol. 10.1111/ene.14339.
  • Li, X., Xu, S., Yu, M., Wang, K., Tao, Y., Zhou, Y., Shi, J., Zhou, M., Wu, B., Yang, Z., Zhang, C., Yue, J., Zhang, Z., Renz, H., Liu, X., Xie, J., Xie, M., & Zhao, J., 2020. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J Allergy Clin Immunol. 146, 110-118.
  • Ozamiz-Etxebarria, N., Dosil-Santamaria, M., Picaza-Gorrochategui, M., & Idoiaga-Mondragon, N., 2020. Stress, anxiety, and depression levels in the initial stage of the COVID-19 outbreak in a population sample in the northern Spain. Cad Saude Publica. 36, e00054020.
  • Özdin, S., & Bayrak Özdin, Ş., 2020. Levels and predictors of anxiety, depression and health anxiety during COVID-19 pandemic in Turkish society: The importance of gender. Int J Soc Psychiatry. 66, 504-511.
  • Peters, M. E., Schwartz, S., Han, D., Rabins, P. V., Steinberg, M., Tschanz, J. T., & Lyketsos, C. G., 2015. Neuropsychiatric symptoms as predictors of progression to severe Alzheimer’s dementia and death: The Cache County Dementia Progression Study. Am J Psychiatry, 172, 460-465.
  • Truzzi, A., Valente, L., Ulstein, I., Engelhardt, E., Laks, J., & Engedal, K., 2012. Burnout in familial caregivers of patients with dementia. Braz J Psychiatry. 34, 405-412.
  • Yıldızhan, E., Ören, N., Erdoğan, A., & Bal, F., 2019. The burden of care and burnout in individuals caring for patients with Alzheimer’s disease. Community Ment Health J. 55, 304-310.
  • Yu, H., Wang, X., He, R., Liang, R., & Zhou, L., 2015. Measuring the caregiver burden of caring for community-residing people with Alzheimer’s disease. PLoS One. 10, e0132168.
There are 20 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Clinical Research
Authors

Nesrin Helvacı Yılmaz 0000-0001-7566-1063

Burcu Polat This is me 0000-0002-4104-8508

Abdülkadir Ermiş 0000-0001-6933-6950

Lütfü Hanoğlu 0000-0002-4104-8508

Publication Date May 1, 2021
Submission Date November 7, 2020
Acceptance Date February 1, 2021
Published in Issue Year 2021 Volume: 38 Issue: 3

Cite

APA Helvacı Yılmaz, N., Polat, B., Ermiş, A., Hanoğlu, L. (2021). Clinical Deterioration of Alzheimer’s Disease Patients During the COVID-19 Pandemic and Caregiver Burden. Journal of Experimental and Clinical Medicine, 38(3), 255-259.
AMA Helvacı Yılmaz N, Polat B, Ermiş A, Hanoğlu L. Clinical Deterioration of Alzheimer’s Disease Patients During the COVID-19 Pandemic and Caregiver Burden. J. Exp. Clin. Med. May 2021;38(3):255-259.
Chicago Helvacı Yılmaz, Nesrin, Burcu Polat, Abdülkadir Ermiş, and Lütfü Hanoğlu. “Clinical Deterioration of Alzheimer’s Disease Patients During the COVID-19 Pandemic and Caregiver Burden”. Journal of Experimental and Clinical Medicine 38, no. 3 (May 2021): 255-59.
EndNote Helvacı Yılmaz N, Polat B, Ermiş A, Hanoğlu L (May 1, 2021) Clinical Deterioration of Alzheimer’s Disease Patients During the COVID-19 Pandemic and Caregiver Burden. Journal of Experimental and Clinical Medicine 38 3 255–259.
IEEE N. Helvacı Yılmaz, B. Polat, A. Ermiş, and L. Hanoğlu, “Clinical Deterioration of Alzheimer’s Disease Patients During the COVID-19 Pandemic and Caregiver Burden”, J. Exp. Clin. Med., vol. 38, no. 3, pp. 255–259, 2021.
ISNAD Helvacı Yılmaz, Nesrin et al. “Clinical Deterioration of Alzheimer’s Disease Patients During the COVID-19 Pandemic and Caregiver Burden”. Journal of Experimental and Clinical Medicine 38/3 (May 2021), 255-259.
JAMA Helvacı Yılmaz N, Polat B, Ermiş A, Hanoğlu L. Clinical Deterioration of Alzheimer’s Disease Patients During the COVID-19 Pandemic and Caregiver Burden. J. Exp. Clin. Med. 2021;38:255–259.
MLA Helvacı Yılmaz, Nesrin et al. “Clinical Deterioration of Alzheimer’s Disease Patients During the COVID-19 Pandemic and Caregiver Burden”. Journal of Experimental and Clinical Medicine, vol. 38, no. 3, 2021, pp. 255-9.
Vancouver Helvacı Yılmaz N, Polat B, Ermiş A, Hanoğlu L. Clinical Deterioration of Alzheimer’s Disease Patients During the COVID-19 Pandemic and Caregiver Burden. J. Exp. Clin. Med. 2021;38(3):255-9.