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Intramuscular meperidine analgesia at the beginning of active phase shortens labor duration without adverse effects on obstetric lacerations and neonatal outcomes

Year 2021, Volume: 38 Issue: 4, 594 - 598, 09.10.2021

Abstract

Objective: The primary objectives of this study were to evaluate the impact of intramuscular meperidine on shortening of the active phase of labor, the neonatal outcome and the rate and severity of perineal lacerations in term pregnant women in the first stage of labor.
Materials and Methods: A total of 571 primiparous term pregnant women delivered vaginally were included into this retrospective study. In 437 of them, meperidine (100 mg IM) at the beginning of the active phase was administered and 134 women did not receive any meperidine dose. The length of labor phases, obstetric lacerations, and neonatal outcomes were recorded.
Results: The results of this study showed that meperidine could be used safely as an obstetric analgesic with its additional benefit of shortening the active phase of the first stage and second stage of labor without increased risk of obstetric lacerations and perinatal adverse outcomes.
Conclusions: In case of limited use of neuroaxil analgesia in a busy state maternity hospital, intramuscular meperidine administration as obstetric analgesia seems beneficial in reducing the length of the active phase of the first stage of labor and the second stage of labor without adversely affecting obstetric lacerations and neonatal outcomes.

References

  • Aburel E. L'anesthésie locale continue (prolongée) en obstétrique. Bull Soc Obstet Gynecol 1931; 20: 35-37.
  • ACOG Committee Opinion 295: pain relief during labor. Obstet Gynecol. 2004; 104: 213.
  • Allman KG, Wilson H, and O’Donnel A. Chapter 41 Regional anaesthesia. In: Oxford Handbook of Anaesthesia. 2006: 1120.
  • Berghella V, Baxter JK, Chauhan SP. Evidence-based labor and delivery management. Am J Obstet Gynecol. 2008; 199: 445-454.
  • Caton D. The History of Obstetric Anesthesia. In: Chestnut’s Obstetric Anesthesia: Principles and Practice. 2009; 114: 1326–1331.
  • Kominiarek MA, Zhang J, VanVeldhuisen P, Troendle J, Beaver J, Hibbard JU. Contemporary labor patterns: the impact of maternal body mass index. Am J Obstet Gynecol. 2011; 205: 244-244.
  • Lang AJ, Sorrell JT, Rodgers CS, Lebeck MM. Anxiety sensitivity as a predictor of labor pain. Eur J Pain. 2006; 10: 263-70.
  • Latta KS, Ginsberg B, Barkin RL. Meperidine: A Critical Review. Am J Ther . 2002; 9: 53-68.
  • Leduc D, Biringer A, Lee L, Dy J “Induction of labour: SOGC Clinical Practice Guideline. J Obs Gynaecol Can. 2013; 35: 840-857.
  • Macarthur AJ, Macarthur C. Incidence, severity, and determinants of perineal pain after vaginal delivery: A prospective cohort study. Am J Obstet Gynecol. 2004; 191: 1199-204.
  • Maronge L, Bogod D. Complications in obstetric anaesthesia. Anaesthesia. 2018; 73: 61–66.
  • Millen KR, Kuo K, Zhao L, Gecsi K. Evidence-based guidelines in labor management. Obstetrical and Gynecological Survey. 2014; 69: 209–217.
  • Mizrachi, Y., Leytes, S., Levy, M., Ginath, S., Bar, J., Ezri, T., Kovo, M. Does meperidine analgesia affect the incidence of obstetric lacerations at vaginal delivery?. J Matern Fetal Neonatal Med 2017: 1-5.
  • Munro A, George RB. Chestnut’s Obstetric Anesthesia Principles and Practice, Fifth Edition. Can J Anesth Can d’anesthésie. 2015; 62: 1027–1028.
  • Nissen E, Widström AM, Lilja G, et al., Effects of routinely given pethidine during labour on infants’ developing breastfeeding behaviour. Effects of dose-delivery time interval and various concentrations of pethidine/norpethidine in cord plasma. Acta Paediatr. 1997; 86: 201–8.
  • Oliveira MRE, Santos MG, Aude DA,et al. [Should maternal anesthesia delay breastfeeding? A systematic review of the literature]. Rev Bras Anestesiol. 2019; 69: 184–96.
  • Pillai A, Bogod D. Chestnut′s Obstetric Anesthesia: Principles and Practice. Br J Anaesth. 2015; 114: 861.
  • Shnider SM, Moya F. Effects of meperidine on the newborn infant. Am J Obstet Gynecol. 1964; 15, 89: 1009–1015.
  • Tita ATN, Rouse DJ. Obstetric Management of Labor and Vaginal Delivery. In: Chestnut’s Obstetric Anesthesia: Principles and Practice. 2009: 223-245.
  • Ullman R, Smith LA, Burns E, Mori R, Dowswell T. Parenteral opioids for maternal pain management in labour. Cochrane Database Syst Rev. 2010; 9: CD007396.
  • Viktrup L. The risk of lower urinary tract symptoms five years after the first delivery*. Neurourol Urodyn [Internet]. 2002; 21: 2–29.
  • Wood A. Treatment of Neuralgic Pains by Narcotic Injections. Br Med J. 1858; 28: 721-723.
  • Zakowski MI, Herman NL. The Placenta: Anatomy, Physiology, and Transfer of Drugs. In: Chestnut’s Obstetric Anesthesia: Principles and Practice. 2009; 4: 55-68.
Year 2021, Volume: 38 Issue: 4, 594 - 598, 09.10.2021

Abstract

References

  • Aburel E. L'anesthésie locale continue (prolongée) en obstétrique. Bull Soc Obstet Gynecol 1931; 20: 35-37.
  • ACOG Committee Opinion 295: pain relief during labor. Obstet Gynecol. 2004; 104: 213.
  • Allman KG, Wilson H, and O’Donnel A. Chapter 41 Regional anaesthesia. In: Oxford Handbook of Anaesthesia. 2006: 1120.
  • Berghella V, Baxter JK, Chauhan SP. Evidence-based labor and delivery management. Am J Obstet Gynecol. 2008; 199: 445-454.
  • Caton D. The History of Obstetric Anesthesia. In: Chestnut’s Obstetric Anesthesia: Principles and Practice. 2009; 114: 1326–1331.
  • Kominiarek MA, Zhang J, VanVeldhuisen P, Troendle J, Beaver J, Hibbard JU. Contemporary labor patterns: the impact of maternal body mass index. Am J Obstet Gynecol. 2011; 205: 244-244.
  • Lang AJ, Sorrell JT, Rodgers CS, Lebeck MM. Anxiety sensitivity as a predictor of labor pain. Eur J Pain. 2006; 10: 263-70.
  • Latta KS, Ginsberg B, Barkin RL. Meperidine: A Critical Review. Am J Ther . 2002; 9: 53-68.
  • Leduc D, Biringer A, Lee L, Dy J “Induction of labour: SOGC Clinical Practice Guideline. J Obs Gynaecol Can. 2013; 35: 840-857.
  • Macarthur AJ, Macarthur C. Incidence, severity, and determinants of perineal pain after vaginal delivery: A prospective cohort study. Am J Obstet Gynecol. 2004; 191: 1199-204.
  • Maronge L, Bogod D. Complications in obstetric anaesthesia. Anaesthesia. 2018; 73: 61–66.
  • Millen KR, Kuo K, Zhao L, Gecsi K. Evidence-based guidelines in labor management. Obstetrical and Gynecological Survey. 2014; 69: 209–217.
  • Mizrachi, Y., Leytes, S., Levy, M., Ginath, S., Bar, J., Ezri, T., Kovo, M. Does meperidine analgesia affect the incidence of obstetric lacerations at vaginal delivery?. J Matern Fetal Neonatal Med 2017: 1-5.
  • Munro A, George RB. Chestnut’s Obstetric Anesthesia Principles and Practice, Fifth Edition. Can J Anesth Can d’anesthésie. 2015; 62: 1027–1028.
  • Nissen E, Widström AM, Lilja G, et al., Effects of routinely given pethidine during labour on infants’ developing breastfeeding behaviour. Effects of dose-delivery time interval and various concentrations of pethidine/norpethidine in cord plasma. Acta Paediatr. 1997; 86: 201–8.
  • Oliveira MRE, Santos MG, Aude DA,et al. [Should maternal anesthesia delay breastfeeding? A systematic review of the literature]. Rev Bras Anestesiol. 2019; 69: 184–96.
  • Pillai A, Bogod D. Chestnut′s Obstetric Anesthesia: Principles and Practice. Br J Anaesth. 2015; 114: 861.
  • Shnider SM, Moya F. Effects of meperidine on the newborn infant. Am J Obstet Gynecol. 1964; 15, 89: 1009–1015.
  • Tita ATN, Rouse DJ. Obstetric Management of Labor and Vaginal Delivery. In: Chestnut’s Obstetric Anesthesia: Principles and Practice. 2009: 223-245.
  • Ullman R, Smith LA, Burns E, Mori R, Dowswell T. Parenteral opioids for maternal pain management in labour. Cochrane Database Syst Rev. 2010; 9: CD007396.
  • Viktrup L. The risk of lower urinary tract symptoms five years after the first delivery*. Neurourol Urodyn [Internet]. 2002; 21: 2–29.
  • Wood A. Treatment of Neuralgic Pains by Narcotic Injections. Br Med J. 1858; 28: 721-723.
  • Zakowski MI, Herman NL. The Placenta: Anatomy, Physiology, and Transfer of Drugs. In: Chestnut’s Obstetric Anesthesia: Principles and Practice. 2009; 4: 55-68.
There are 23 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Clinical Research
Authors

Mehmet Güçlü 0000-0002-8295-0629

Nazan Yurtcu 0000-0003-4725-043X

Samettin Çelik 0000-0002-6407-1129

Canan Soyer Çalışkan 0000-0002-9889-5249

Şafak Hatırnaz 0000-0001-8859-0639

Handan Çelik 0000-0001-5201-9385

Publication Date October 9, 2021
Submission Date February 25, 2021
Acceptance Date March 14, 2021
Published in Issue Year 2021 Volume: 38 Issue: 4

Cite

APA Güçlü, M., Yurtcu, N., Çelik, S., Soyer Çalışkan, C., et al. (2021). Intramuscular meperidine analgesia at the beginning of active phase shortens labor duration without adverse effects on obstetric lacerations and neonatal outcomes. Journal of Experimental and Clinical Medicine, 38(4), 594-598.
AMA Güçlü M, Yurtcu N, Çelik S, Soyer Çalışkan C, Hatırnaz Ş, Çelik H. Intramuscular meperidine analgesia at the beginning of active phase shortens labor duration without adverse effects on obstetric lacerations and neonatal outcomes. J. Exp. Clin. Med. October 2021;38(4):594-598.
Chicago Güçlü, Mehmet, Nazan Yurtcu, Samettin Çelik, Canan Soyer Çalışkan, Şafak Hatırnaz, and Handan Çelik. “Intramuscular Meperidine Analgesia at the Beginning of Active Phase Shortens Labor Duration Without Adverse Effects on Obstetric Lacerations and Neonatal Outcomes”. Journal of Experimental and Clinical Medicine 38, no. 4 (October 2021): 594-98.
EndNote Güçlü M, Yurtcu N, Çelik S, Soyer Çalışkan C, Hatırnaz Ş, Çelik H (October 1, 2021) Intramuscular meperidine analgesia at the beginning of active phase shortens labor duration without adverse effects on obstetric lacerations and neonatal outcomes. Journal of Experimental and Clinical Medicine 38 4 594–598.
IEEE M. Güçlü, N. Yurtcu, S. Çelik, C. Soyer Çalışkan, Ş. Hatırnaz, and H. Çelik, “Intramuscular meperidine analgesia at the beginning of active phase shortens labor duration without adverse effects on obstetric lacerations and neonatal outcomes”, J. Exp. Clin. Med., vol. 38, no. 4, pp. 594–598, 2021.
ISNAD Güçlü, Mehmet et al. “Intramuscular Meperidine Analgesia at the Beginning of Active Phase Shortens Labor Duration Without Adverse Effects on Obstetric Lacerations and Neonatal Outcomes”. Journal of Experimental and Clinical Medicine 38/4 (October 2021), 594-598.
JAMA Güçlü M, Yurtcu N, Çelik S, Soyer Çalışkan C, Hatırnaz Ş, Çelik H. Intramuscular meperidine analgesia at the beginning of active phase shortens labor duration without adverse effects on obstetric lacerations and neonatal outcomes. J. Exp. Clin. Med. 2021;38:594–598.
MLA Güçlü, Mehmet et al. “Intramuscular Meperidine Analgesia at the Beginning of Active Phase Shortens Labor Duration Without Adverse Effects on Obstetric Lacerations and Neonatal Outcomes”. Journal of Experimental and Clinical Medicine, vol. 38, no. 4, 2021, pp. 594-8.
Vancouver Güçlü M, Yurtcu N, Çelik S, Soyer Çalışkan C, Hatırnaz Ş, Çelik H. Intramuscular meperidine analgesia at the beginning of active phase shortens labor duration without adverse effects on obstetric lacerations and neonatal outcomes. J. Exp. Clin. Med. 2021;38(4):594-8.