The Relationship of Bile Acid with Biochemical Tests in the Diagnosis of Intrahepatic Cholestasis of Pregnancy

Cuma Taşın; Revan Sabri Çiftçi

Research Article

The Relationship of Bile Acid with Biochemical Tests in the Diagnosis of Intrahepatic Cholestasis of Pregnancy

Year 2021, Volume: 38 Issue: 4, 485 - 489, 09.10.2021

Cuma Taşın , Revan Sabri Çiftçi

Abstract

Intrahepatic pregnancy cholestasis (ICP) is associated with increased fetal complications. It is linked to an increased risk. Early diagnosis of this disease reduces these fetal complications. In this study, it was aimed to determine the sensitivity and specificity of biochemical tests according to cut off values.

Keywords

Intrahepatic cholestasis of pregnancy, Bile acid, ALT- serum alanine transaminase, AST-serum aspartate transaminase

Project Number

YOK

References

1.Kulhan M, Kulhan NG, Nayki U, Nayki C, Ata N. Intrahepatic cholestasis of pregnancy and fetal outcomes. Mini review. Arch Med Sci Civil Dis 2017; 2: e85-6.
2. Williamson C, Geenes V. Intrahepatic cholestasis of pregnancy. Obstet Gynecol 2014; 124: 120-33.
3. Ozkan S, Ceylan Y, Ozkan OV, et al. Review of a challenging clinical issue: intrahepatic cholestasis of pregnancy. World J Gastroenterol 2015; 21: 7134-41.
4. Tayyar A, Temel Yuksel I, et al. Maternal copeptin levels in intrahepatic cholestasis of pregnancy. J Matern Fetal Neonatal Med 2017 Jun 14: 1–5. doi: 10.1080/14767058.2017.1335708.
5. Geenes V, Chappell LC, Seed PT, et al. Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study. Hepatology 2014; 59: 1482-91.
6. Sugino N, Takiguchi S, Umekawa T, et al. Oxidative stress and pregnancy outcome: a workshop report. Placenta Netherlands 2007; 28: 48-50.
7. Karaahmet E, Ay Gungor ANC, Topaloglu N, Sahin B, Kivrak Y. Prevalence of psychiatric disorders during pregnancy and their effect on birth weight. Arch Med Sci Civil Dis 2016; 1: e24-9.
8. Arrese M, Macias RIR, Briz O, et al. Molecular pathogenesis of intrahepatic cholestasis of pregnancy. Expert Rev Mol Med 2008; 10: e9.
9. Chen J, Deng W, Wang J, Shao Y, Ou M, Ding M. Primary bile acids as potential biomarkers for the clinical grading of intrahepatic cholestasis of pregnancy. Int J Gynaecol Obstet 2013; 122: 5-8.
10. Friberg AK, Zingmark V, Lyndrup J. Early induction of labor in high-risk intrahepatic cholestasis of pregnancy: What are the costs? Arch Gynecol Obstet. 2016;294(4):709-14.
11. Kariv R, Leshno M, Beth-Or A, Strul H, Blendis L, Kokia E, Noff D, et al. Re-evaluation of serum alanine aminotransferase upper normal limit and its modulating factors in a large-scale population study. Liver Int 2006; 26: 445-50.
12. Herraez E, Lozano E, Poli E, Keitel V, De Luca D,Williamson C, et al. Role of macrophages in bile acid induced inflammatory response of fetal lung during maternal cholestasis. J Mol Med (Berl). 2014;92(4):359-72.
13. De Luca D, Minucci A, Zecca E, Piastra M, Pietrini D, Carnielli VP, et al. Bile acids cause secretory phospholipase A2 activity enhancement, revertible by exogenous surfactant administration. Intensive Care Med. 2009;35(2):321-6.
14. Riely CA, Bacq Y. Intrahepatic cholestasis of pregnancy. Clin Liver Dis 2004; 8: 167-76.
15. Kondrackiene J, Kupcinskas L. Intrahepatic cholestasis of pregnancy-current achievements and unsolved problems. World J Gastroenterol 2008; 14: 5781-8.
16. Pascual MJ , Se r rano MA, El -Mi r MY, Mac ias RI , Jiménez F, Marin JJ. Relationship between asymptomatic hypercholanaemia of pregnancy and progesterone metabolism. Clin Sci (Lond) 2002; 102: 587-593
17. Walker IA, Nelson-Piercy C, Williamson C. Role of bile acid measurement in pregnancy. Ann Clin Biochem 2002; 39: 105-113
18. Glantz A, Marschall H-U, Mattsson L-A. Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates. Hepatology 2004; 4: 467-74.
19. Shaw D, Frohlich J, Wittmann BA, Willms M. A prospective study of 18 patients with cholestasis of pregnancy. Am J Obstet Gynecol 1982; 142: 621-625
20. Laatikainen TJ. Fetal bile acid levels in pregnancies complicated by maternal intrahepatic cholestasis. Am J Obstet Gynecol 1975; 122: 852-856
21. Colombo C, Roda A, Roda E, Buscaglia M, dell'Agnola CA, Filippetti P, Ronchi M, Sereni F. Correlation between fetal and maternal serum bile acid concentrations. Pediatr Res1985; 19: 227-231
22. Zecca E, De Luca D, Baroni S, Vento G, Tiberi E, Romagnoli C. Bile acid-induced lung injury in newborn infants: a bronchoalveolar lavage fluid study. Pediatrics 2008; 121:e146-e149
23. Zecca E, De Luca D, Marras M, Caruso A, Bernardini T, Romagnoli C. Intrahepatic cholestasis of pregnancy and neonatal respiratory distress syndrome. Pediatrics 2006; 117:1669-1672
24. Sentilhes L, Verspyck E, Pia P, Marpeau L. Fetal death in a patient with intrahepatic cholestasis of pregnancy. Obstet Gynecol 2006; 107: 458.
25. Johnston WG, Baskett TF. Obstetric cholestasis. A 14 year review. Am J Obstet Gynecol 1979; 133: 299-301
26. Reid R, Ivey KJ, Rencoret RH, Storey B. Fetal complications of obstetric cholestasis. Br Med J 1976; 1: 870-872
27. Lee RH, Kwok KM, Ingles S, Wilson ML, Mullin P, Incerpi M, Pathak B, Goodwin TM. Pregnancy outcomes during an era of aggressive management for intrahepatic cholestasis of pregnancy. Am J Perinatol 2008; 25: 341-345
28. Girling JC, Dow E, Smith JH. Liver function tests in preeclampsia: importance of comparison with a reference range derived for normal pregnancy. Br J Obstet Gynaecol 1997;104: 246-250
29. Bacq Y, Zarka O, Bréchot JF, Mariotte N, Vol S, Tichet J, Weill J. Liver function tests in normal pregnancy: a prospective study of 103 pregnant women and 103 matched controls. Hepatology 1996; 23: 1030-1034
30. Heikkinen J. Serum bile acids in the early diagnosis of intrahepatic cholestasis of pregnancy. Obstet Gynecol 1983;61: 581-587
31. Prati D, Taioli E, Zanella A, Della Torre E, Butelli S, Del Vecchio E, Vianello L, et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002; 137: 1-10
32. Fisk NM, Bye WB, Storey GN. Maternal features of obstetric cholestasis: 20 years experience at King George V Hospital. Aust N Z J Obstet Gynaecol 1988; 28: 172-176
33. Laatikainen T, Ikonen E. Serum bile acids in cholestasis of pregnancy. Obstet Gynecol 1977; 50: 313-318
34. Brites D, Rodrigues CM, van-Zeller H, Brito A, Silva R. Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: Portugal. Eur J Obstet Gynecol Reprod Biol 1998; 80:31-38
35. Bacq Y, Sapey T, Bréchot MC, Pierre F, Fignon A, Dubois F. Intrahepatic cholestasis of pregnancy: a French prospective study. Hepatology 1997; 26: 358-364
36. Milkiewicz P, Gallagher R, Chambers J, Eggington E, Weaver J, Elias E. Obstetric cholestasis with elevated gamma glutamyl transpeptidase: incidence, presentation and treatment. J Gastroenterol Hepatol 2003; 18: 1283-1286

Year 2021, Volume: 38 Issue: 4, 485 - 489, 09.10.2021

Cuma Taşın , Revan Sabri Çiftçi

Abstract

Supporting Institution

YOK

Project Number

YOK

References

1.Kulhan M, Kulhan NG, Nayki U, Nayki C, Ata N. Intrahepatic cholestasis of pregnancy and fetal outcomes. Mini review. Arch Med Sci Civil Dis 2017; 2: e85-6.
2. Williamson C, Geenes V. Intrahepatic cholestasis of pregnancy. Obstet Gynecol 2014; 124: 120-33.
3. Ozkan S, Ceylan Y, Ozkan OV, et al. Review of a challenging clinical issue: intrahepatic cholestasis of pregnancy. World J Gastroenterol 2015; 21: 7134-41.
4. Tayyar A, Temel Yuksel I, et al. Maternal copeptin levels in intrahepatic cholestasis of pregnancy. J Matern Fetal Neonatal Med 2017 Jun 14: 1–5. doi: 10.1080/14767058.2017.1335708.
5. Geenes V, Chappell LC, Seed PT, et al. Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study. Hepatology 2014; 59: 1482-91.
6. Sugino N, Takiguchi S, Umekawa T, et al. Oxidative stress and pregnancy outcome: a workshop report. Placenta Netherlands 2007; 28: 48-50.
7. Karaahmet E, Ay Gungor ANC, Topaloglu N, Sahin B, Kivrak Y. Prevalence of psychiatric disorders during pregnancy and their effect on birth weight. Arch Med Sci Civil Dis 2016; 1: e24-9.
8. Arrese M, Macias RIR, Briz O, et al. Molecular pathogenesis of intrahepatic cholestasis of pregnancy. Expert Rev Mol Med 2008; 10: e9.
9. Chen J, Deng W, Wang J, Shao Y, Ou M, Ding M. Primary bile acids as potential biomarkers for the clinical grading of intrahepatic cholestasis of pregnancy. Int J Gynaecol Obstet 2013; 122: 5-8.
10. Friberg AK, Zingmark V, Lyndrup J. Early induction of labor in high-risk intrahepatic cholestasis of pregnancy: What are the costs? Arch Gynecol Obstet. 2016;294(4):709-14.
11. Kariv R, Leshno M, Beth-Or A, Strul H, Blendis L, Kokia E, Noff D, et al. Re-evaluation of serum alanine aminotransferase upper normal limit and its modulating factors in a large-scale population study. Liver Int 2006; 26: 445-50.
12. Herraez E, Lozano E, Poli E, Keitel V, De Luca D,Williamson C, et al. Role of macrophages in bile acid induced inflammatory response of fetal lung during maternal cholestasis. J Mol Med (Berl). 2014;92(4):359-72.
13. De Luca D, Minucci A, Zecca E, Piastra M, Pietrini D, Carnielli VP, et al. Bile acids cause secretory phospholipase A2 activity enhancement, revertible by exogenous surfactant administration. Intensive Care Med. 2009;35(2):321-6.
14. Riely CA, Bacq Y. Intrahepatic cholestasis of pregnancy. Clin Liver Dis 2004; 8: 167-76.
15. Kondrackiene J, Kupcinskas L. Intrahepatic cholestasis of pregnancy-current achievements and unsolved problems. World J Gastroenterol 2008; 14: 5781-8.
16. Pascual MJ , Se r rano MA, El -Mi r MY, Mac ias RI , Jiménez F, Marin JJ. Relationship between asymptomatic hypercholanaemia of pregnancy and progesterone metabolism. Clin Sci (Lond) 2002; 102: 587-593
17. Walker IA, Nelson-Piercy C, Williamson C. Role of bile acid measurement in pregnancy. Ann Clin Biochem 2002; 39: 105-113
18. Glantz A, Marschall H-U, Mattsson L-A. Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates. Hepatology 2004; 4: 467-74.
19. Shaw D, Frohlich J, Wittmann BA, Willms M. A prospective study of 18 patients with cholestasis of pregnancy. Am J Obstet Gynecol 1982; 142: 621-625
20. Laatikainen TJ. Fetal bile acid levels in pregnancies complicated by maternal intrahepatic cholestasis. Am J Obstet Gynecol 1975; 122: 852-856
21. Colombo C, Roda A, Roda E, Buscaglia M, dell'Agnola CA, Filippetti P, Ronchi M, Sereni F. Correlation between fetal and maternal serum bile acid concentrations. Pediatr Res1985; 19: 227-231
22. Zecca E, De Luca D, Baroni S, Vento G, Tiberi E, Romagnoli C. Bile acid-induced lung injury in newborn infants: a bronchoalveolar lavage fluid study. Pediatrics 2008; 121:e146-e149
23. Zecca E, De Luca D, Marras M, Caruso A, Bernardini T, Romagnoli C. Intrahepatic cholestasis of pregnancy and neonatal respiratory distress syndrome. Pediatrics 2006; 117:1669-1672
24. Sentilhes L, Verspyck E, Pia P, Marpeau L. Fetal death in a patient with intrahepatic cholestasis of pregnancy. Obstet Gynecol 2006; 107: 458.
25. Johnston WG, Baskett TF. Obstetric cholestasis. A 14 year review. Am J Obstet Gynecol 1979; 133: 299-301
26. Reid R, Ivey KJ, Rencoret RH, Storey B. Fetal complications of obstetric cholestasis. Br Med J 1976; 1: 870-872
27. Lee RH, Kwok KM, Ingles S, Wilson ML, Mullin P, Incerpi M, Pathak B, Goodwin TM. Pregnancy outcomes during an era of aggressive management for intrahepatic cholestasis of pregnancy. Am J Perinatol 2008; 25: 341-345
28. Girling JC, Dow E, Smith JH. Liver function tests in preeclampsia: importance of comparison with a reference range derived for normal pregnancy. Br J Obstet Gynaecol 1997;104: 246-250
29. Bacq Y, Zarka O, Bréchot JF, Mariotte N, Vol S, Tichet J, Weill J. Liver function tests in normal pregnancy: a prospective study of 103 pregnant women and 103 matched controls. Hepatology 1996; 23: 1030-1034
30. Heikkinen J. Serum bile acids in the early diagnosis of intrahepatic cholestasis of pregnancy. Obstet Gynecol 1983;61: 581-587
31. Prati D, Taioli E, Zanella A, Della Torre E, Butelli S, Del Vecchio E, Vianello L, et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002; 137: 1-10
32. Fisk NM, Bye WB, Storey GN. Maternal features of obstetric cholestasis: 20 years experience at King George V Hospital. Aust N Z J Obstet Gynaecol 1988; 28: 172-176
33. Laatikainen T, Ikonen E. Serum bile acids in cholestasis of pregnancy. Obstet Gynecol 1977; 50: 313-318
34. Brites D, Rodrigues CM, van-Zeller H, Brito A, Silva R. Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: Portugal. Eur J Obstet Gynecol Reprod Biol 1998; 80:31-38
35. Bacq Y, Sapey T, Bréchot MC, Pierre F, Fignon A, Dubois F. Intrahepatic cholestasis of pregnancy: a French prospective study. Hepatology 1997; 26: 358-364
36. Milkiewicz P, Gallagher R, Chambers J, Eggington E, Weaver J, Elias E. Obstetric cholestasis with elevated gamma glutamyl transpeptidase: incidence, presentation and treatment. J Gastroenterol Hepatol 2003; 18: 1283-1286

There are 36 citations in total.

Details

Primary Language	English
Subjects	Health Care Administration
Journal Section	Clinical Research
Authors	Cuma Taşın 0000-0002-9315-4791 Revan Sabri Çiftçi 0000-0003-2560-3142
Project Number	YOK
Publication Date	October 9, 2021
Submission Date	March 10, 2021
Acceptance Date	March 27, 2021
Published in Issue	Year 2021 Volume: 38 Issue: 4

Cite

APA	Taşın, C., & Çiftçi, R. S. (2021). The Relationship of Bile Acid with Biochemical Tests in the Diagnosis of Intrahepatic Cholestasis of Pregnancy. Journal of Experimental and Clinical Medicine, 38(4), 485-489.
AMA	Taşın C, Çiftçi RS. The Relationship of Bile Acid with Biochemical Tests in the Diagnosis of Intrahepatic Cholestasis of Pregnancy. J. Exp. Clin. Med. October 2021;38(4):485-489.
Chicago	Taşın, Cuma, and Revan Sabri Çiftçi. “The Relationship of Bile Acid With Biochemical Tests in the Diagnosis of Intrahepatic Cholestasis of Pregnancy”. Journal of Experimental and Clinical Medicine 38, no. 4 (October 2021): 485-89.
EndNote	Taşın C, Çiftçi RS (October 1, 2021) The Relationship of Bile Acid with Biochemical Tests in the Diagnosis of Intrahepatic Cholestasis of Pregnancy. Journal of Experimental and Clinical Medicine 38 4 485–489.
IEEE	C. Taşın and R. S. Çiftçi, “The Relationship of Bile Acid with Biochemical Tests in the Diagnosis of Intrahepatic Cholestasis of Pregnancy”, J. Exp. Clin. Med., vol. 38, no. 4, pp. 485–489, 2021.
ISNAD	Taşın, Cuma - Çiftçi, Revan Sabri. “The Relationship of Bile Acid With Biochemical Tests in the Diagnosis of Intrahepatic Cholestasis of Pregnancy”. Journal of Experimental and Clinical Medicine 38/4 (October 2021), 485-489.
JAMA	Taşın C, Çiftçi RS. The Relationship of Bile Acid with Biochemical Tests in the Diagnosis of Intrahepatic Cholestasis of Pregnancy. J. Exp. Clin. Med. 2021;38:485–489.
MLA	Taşın, Cuma and Revan Sabri Çiftçi. “The Relationship of Bile Acid With Biochemical Tests in the Diagnosis of Intrahepatic Cholestasis of Pregnancy”. Journal of Experimental and Clinical Medicine, vol. 38, no. 4, 2021, pp. 485-9.
Vancouver	Taşın C, Çiftçi RS. The Relationship of Bile Acid with Biochemical Tests in the Diagnosis of Intrahepatic Cholestasis of Pregnancy. J. Exp. Clin. Med. 2021;38(4):485-9.

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