Mechanisms and therapeutic opportunities in erectile dysfunction for advanced glycation end products (AGEs)

Year 2023, Volume: 40 Issue: 2, 390 - 400, 19.07.2023

Farhat Chaudhari Ahmad Ali , Prairna Balyan

Abstract

Diabetes mellitus (DM) is one of the world's most common diseases. Its impact on the male reproductive system is one of its key impacts. Erectile dysfunction and decreased libido affect up to 90% of diabetic men, which can result in male infertility. Several researchers have investigated the negative impacts of reactive oxygen species and the subsequent development of oxidative stress that occurs due to DM. Non-enzymatic glycosylation products (AGEs) have been found in diabetic men's reproductive tracts. AGEs work by generating reactive oxygen species (ROS) or attaching to receptors on their own. The binding of AGE to the receptor (RAGE) has been demonstrated to play a role in physiological processes such as lung homeostasis, bone metabolism, neural systems, and the immune system. The human body has several defenses against AGE accumulation, which are reduced in diabetic individuals. The situation can be improved by using some preventive measures, either by using oral drugs or natural therapeutic agents. Also, herbal medicine is gaining popularity in the market to treat various ailments. Because of the long cultural history of use and the present resurgent interest, using herbal treatments to manage male sexual dysfunction is beneficial.

Keywords

Diabetes, Erectile Dysfunction (ED), Male infertility, Receptor for Advanced glycation end products (RAGE), Reactive Oxygen Species (ROS)

Supporting Institution

Research Society for Studies on Diabetes in India (RSSDI)

Project Number

RSSDI/HQ/Grants/2017/342

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