Prognostic significance of Cyclin d1 / p16 / Ki-67 markers in bladder urothelial carcinomas

Year 2017, Volume: 9 Issue: 2, 73 - 78, 01.06.2017

İlyas Sayar

https://doi.org/10.21601/ortadogutipdergisi.265416

Abstract

Objectives: The
results of a small number of studies on the expression of cyclin D1 / p16 /
Ki-67 in urothelial carcinomas, either individually or in combination with each
other, differ. In this study, the relationship between Cyclin d1 / p16 / Ki-67
markers in pathologic prognostic factors of bladder urothelial carcinoma was
investigated.

Materials and methods:
A total of 149 bladder urothelial carcinomas were selected from the pathology
archive. In all cases, histopathological findings were reviewed and graded
according to the WHO / ISUP system. Immunohistochemical staining for Cyclin d1
/ p16 / Ki-67 was performed on a selected tissue block for each case.

Results:
The rate of cyclin d1 staining was found to be higher in the first pT stage
Ta-T1, low grade, recurrence and non-progressive cases. The rate of positivity
is significantly higher in cases with high grade p16 staining, recurrence and
high mortality. The Ki-67 staining rate is significantly lower than the first
pT stage Ta-T1, low grade, high (score 3) incidence in cases without recurrence
and progression, first pT stage T2-T4, high grade, recurrence and progression.

Conclusion:
Cyclin d1 / p16 / Ki-67 markers in patients with bladder urothelial carcinoma
have a statistically significant association with tumor grade and recurrence.
Cyclin d1 / p16 / Ki-67 association may play a role in the progression and
differentiation of urothelial carcinomas.

Keywords

Urothelial carcinoma, Cyclin D1, Ki- 67

Mesane ürotelyal karsinomlarında Siklin D1/p16/Ki-67 belirteçlerinin prognostik önemi

Abstract

ÖZ

Amaç:
Ürotelyal karsinomların Siklin D1/p16/Ki-67   ekspresyonunu araştıran gerek ayrı ayrı ve
gerekse ikili kombinasyonu ile yapılan  az
sayıda çalışmada  sonuçlar farklılık
göstermektedir. Bu çalışmada, mesane ürotelyal karsinomlarında Siklin D1/p16/Ki-67
belirteçlerinin patolojik prognostik faktörler 
ile ilişkisi araştırıldı.

Yöntem ve gereç:
Toplam 149 mesane ürotelyal karsinomu patoloji arşivinden  seçildi. Tüm olgularda histopatolojik bulgular
tekrar gözden geçirildi ve WHO/ISUP 
sistemine göre derecelendirme uygulandı. Her olgu için seçilen bir doku
bloğuna Siklin D1/p16/Ki-67   için immünhistokimyasal boyama işlemi
gerçekleştirildi.

Bulgular:
Siklin D1 boyanma oranı ilk pT evresi
Ta-T1, düşük grade, rekürrens ve
progresyon görülmeyen olgularda daha yüksek bulunmuştur. p16 boyanma oranı; yüksek grade, rekürrens görülen ve mortalite yüksek
görülen olgularda anlamlı düzeyde yüksektir. Ki-67 boyanma oranı ise ilk pT
evresi Ta-T1, düşük grade, rekürrens ve progresyon görülmeyen olgularda high
(skor 3) görülme oranı, ilk pT evresi T2-T4, yüksek grade, rekürrens ve
progresyon görülen olgulara göre anlamlı düzeyde düşüktür.

Sonuç:
Mesane ürotelyal karsinomlu hastalarda Siklin D1/p16/Ki-67 belirteçlerinin
tümörün yüksek gradeliği ve rekürrensiyle istatistiksel olarak anlamlı bir
birliktelik vardır. Siklin D1/p16/Ki-67 birlikteliği  ürotelyal karsinomların progresyonunda ve
diferansiyasyonunda rol oynayabilir.

Keywords

Ürotelyal Karsinom, Siklin D1, Ki-67

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