The relationship between localization and neutrophil lymphocyte ratio in colon carcinoma

Year 2018, Volume: 10 Issue: 1, 64 - 67, 30.03.2018

Sema Türker , Cengiz Karaçin G. İnanç İmamoğlu , Tülay Eren , Ramazan Esen , Ebru Çılbır , Mustafa Altınbaş , Özlem Aydın İsak Doğan Yazılıtaş

https://doi.org/10.21601/ortadogutipdergisi.398756

Abstract

Objective:
We
aimed to compare the neutrophil lymphocyte ratio(NLR), which is a simple
method, to determine whether the difference between the right colon and the
left colon tumors in our study is related to the inflammatory process between
the two regions.

Material
and Method: We retrospectively
reviewed the files of 142 patients who were diagnosed with stage 1-3 colorectal
cancer between July 2011 and June 2015 at Medical Oncology Department, Dışkapı
Yıldırım Beyazıt Education and Research Hospital. We examined whether tumor
localization correlates with neutrophil lymphocyte ratio (NLR) and disease-free
survival.

Results:
The
patients were divided into right and left colon based on splenic flexure. There
were 35 patients (24%) defined as right colon and 107 (76%) patients defined as
left colon. 85 (60%) of the patients were male and 57 (40%) were female. The
ratio of neutrophil and lymphocytes at diagnosis was compared. The mean NLR values
of the left and right colon were calculated as 4.43 and 5.05, respectively. No
statistically significant difference was found between the right and left colon
(p = 0.234). The disease-free survival rates were lower in the right colon
tumors than in the left colon, but not statistically significant (0,88 / 0,84
40th and 60th at 20th month) 0.80 / 0.77 and0,80/0,77; p = 0.064)

Conclusion:
In
our study, we could not find any relation between the NLR and the localization
of the disease in patients with early stage colorectal cancer. Disease-free
survival rates were calculated to be lower in right colon tumors, although they
did not reach statistical significance with respect to left colon.

Keywords

Right-left colon, colorectal cancer, NLR

Kolon kanserinde lokalizasyon ile nötrofil lenfosit oranı arasındaki ilişki

Abstract

Amaç:
Çalışmamızda sağ kolon ile sol kolon yerleşimli tümörler arasındaki farkın iki
bölge arasındaki inflamatuvar süreçle ilişkili olup olmadığını basit bir yöntem
olan nötrofil lenfosit oranına bakarak karşılaştırmayı amaçladık.

Gereç
ve Yöntem: Dışkapı Yıldırım Beyazıt Eğitim ve
Araştırma Hastanesi Tıbbi Onkoloji bölümüne Temmuz 2011-Haziran 2015 tarihleri
arasında başvuran evre 1-3 kolorektal kanser tanısı almış 142 hastanın
dosyalarını retrospektif olarak inceledik. 
Tümör lokalizasyonu ile nötrofil lenfosit oranı (NLO) ve hastalıksız sağ
kalım arasında ilişki olup olmadığını araştırdık.

Bulgular:
Hastalar splenik fleksura baz alınarak sağ ve sol kolon şeklinde ikiye ayrıldı.
Sağ kolon olarak tanımladığımız 35 (%24), sol kolon olarak tanımladığımız 107
(%76) hasta vardı. Hastaların 85’i (%60) erkek, 57’si (%40) kadındı. Tanı
anındaki NLO karşılaştırıldı. Sağ ve sol kolonun NLO ortalama değerleri
sırasıyla 4,43 ve 5,05 olarak hesaplandı. Sağ ve sol kolon arasında NLO
açısından istatiksel olarak anlamlı farklılık saptanmadı (p=0.234). Hastalıksız sağ kalım oranları sağ kolon tümörlerinde sol
kolona göre istatiksel anlamlılığa ulaşmasa da daha düşük olarak hesaplandı (20.
ayda 0,88/0,84; 40. ve 60. ayda sırasıyla 0,80/0,77 ve 0,80/0,77; p =0,064).

Sonuçlar:
Yaptığımız çalışmada metastatik olmayan kolorektal kanserli hastalarda tanı
anında bakılan NLO ile hastalığın lokalizasyonu arasında ilişki bulamadık. Hastalıksız
sağ kalım oranlarını sağ kolon tümörlerinde sol kolona göre istatiksel
anlamlılığa ulaşmasa da daha düşük olarak hesapladık. 

Keywords

Sağ-sol kolon, kolorektal kanser, NLO

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