İnterlökin-6 düzeyinin epileptik nöbet ile ilişkisi

Year 2020, Volume: 12 Issue: 2, 225 - 232, 01.06.2020

Reyyan Ezer , Hülya Ertaşoğlu Toydemir , Munevver Çelik Gökyiğit

https://doi.org/10.21601/ortadogutipdergisi.651791

Abstract

Amaç: Epileptik nöbet geçiren hastalarda interlökin-6 (IL-6) düzeyinin nöbet türü, etiyolojisi ile infeksiyon parametreleri olan ateş, lökosit ve c-reaktif protein (CRP) ile ilişkisinin incelenmesi amaçlandı.
Gereç ve Yöntem: Çalışmaya 24 kişiden oluşan hasta grubu ve 24 kişiden oluşan kontrol grubu olmak üzere toplam 48 kişi dahil edildi. Hastaların IL-6, ateş, lökosit ve CRP değerleri ölçülerek kaydedildi. Hastalar nöbet türüne ve etiyolojisine göre sınıflandırıldı. IL-6 düzeylerindeki yüksekliğin, infeksiyon parametreleri, nöbet türü ve etiyolojisiyle olan ilişkisi değerlendirildi.
Bulgular: IL-6 düzeyi nöbet hastalarında kontrol grubuna göre yüksek bulundu. Epilepsi hastalarında IL-6 düzeylerindeki yükselmenin ateş, lökosit ve CRP düzeylerindeki yükselme ile arasında korelasyon bulunmadı. Hastalar nöbet türüne göre değerlendirildi. Hasta grubu ve kontrol grubunun IL-6 düzeyleri karşılaştırıldığında kontrol grubu ile parsiyel nöbet geçiren hastalarla arasında anlamlı fark bulunmazken (p=0,270), primer jeneralize, sekonder jeneralize ve jeneralize status ile arasında anlamlı fark belirlendi (sırasıyla p=0,012, p=0,011, p=0,040). Nöbet etiyolojisi ile IL-6 düzeyleri arasında ilişki saptanmadı.
Sonuç: Epileptik nöbet geçiren hastalarda IL-6 düzeyi diğer infeksiyöz parametrelerden ve etiyolojiden bağımsız olarak yüksek saptanabilmektedir. IL-6 düzeyi, primer jeneralize, sekonder jeneralize nöbetlerde ve jeneralize statusta, parsiyel nöbetlere göre anlamlı olarak yüksek bulunabilir.

Keywords

epilepsi, interlökin-6, epileptogenez, infeksiyon

The relationship between interleukin-6 and epileptic seizure

Abstract

Aim: The aim of this study was to evaluate the relationship between interleukin-6 (IL-6) levels and the type of the seizure, etiology of the seizure and the infection parameters which were fever, leukocyte count and c-reactive protein (CRP) in epileptic patients.
Material and Methods: A total of 48 people were included in the study, containing a patient group of 24 and a control group of 24. IL-6, fever, leukocyte and CRP levels were measured and recorded. The patients were categorized according to the type and etiology of the seizures. The relationship between IL-6 levels and infection parameters, type and etiology of seizures were evaluated.
Results: IL-6 levels were significantly higher in epileptic patients than that of the control group. There were no correlations between IL-6 levels and fever, leukocyte and CRP. The patients were evaluated according to the seizure type. There was no significant relationship between IL-6 levels of control group and IL-6 levels of patients with partial epileptic seizures (p=0.270). However, there was significant relationship between IL-6 levels of the control group and that of patients with primary generalized, secondary generalized seizures and generalized status epilepticus (p=0.012, p=0.011 and p=0.040, respectively). Epilepsy etiology was not associated with levels of IL-6.
Conclusion: High levels of IL-6 after epileptic seizures might be detected independent from infection parameters and epilepsy etiology. IL-6 levels might be higher in patients with primary generalized, secondary generalized seizures and generalized status epilepticus than that of patients with partial seizures.

Keywords

epilepsy, interleukin-6, epileptogenesis, infection

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