Hyponatremia due to duloxetine use in an elderly woman patient

Year 2020, Volume: 12 Issue: 2, 295 - 298, 01.06.2020

Buket Cinemre Ali Erdoğan , Burak Kulaksızoğlu , Mert Sinan Bingöl

https://doi.org/10.21601/ortadogutipdergisi.762498

Abstract

Hyponatremia is a potentially dangerous side effect of antidepressants. Almost every antidepressant can cause hyponatremia. Duloxetine-induced hyponatremia is a side effect that is usually seen in older women. In addition to advanced age and female sex; low body weight, presence of comorbid diseases are other important risk factors for the development of hyponatremia. In this case report we present a patient with depressive disorder who developed hyponatremia with duloxetine treatment which resolved immediately after the cessation of the medication with supportive electrolyte treatment. In our case, the resolution of hyponatremia with supportive electrolyte treatment in addition to the cessation of duloxetine reminds us about the importance of monitoring sodium levels both before and after antidepressant treatment in geriatric populations.

Keywords

hyponatremia, duloxetine, antidepressant side effect

Yaşlı bir kadın hastada duloksetin kullanımına bağlı hiponatremi

Abstract

Hiponatremi, antidepresanların potansiyel olarak tehlikeli bir yan etkisidir. Hemen hemen her antidepresan hiponatremiye neden olabilir. Duloksetin kaynaklı hiponatremi genellikle yaşlı kadınlarda görülen bir yan etkidir. İleri yaş ve kadın cinsiyetine ek olarak; düşük vücut ağırlığı, komorbid hastalıkların varlığı hiponatremi gelişimi için diğer önemli risk faktörleridir. Bu olgu sunumunda, ilacın kesilmesinden hemen sonra düzelen duloksetin tedavisi ile hiponatremi gelişen depresif bozukluğu olan bir hasta sunulmaktadır. Bizim olgumuzda, duloksetin kesilmesine ek olarak, hiponatreminin destekleyici elektrolit tedavisi ile çözülmesi bize geriatrik popülasyonlarda antidepresan tedavisinden önce ve sonra sodyum seviyelerinin izlenmesinin önemini hatırlatmaktadır.

Keywords

hiponatremi, duloksetin, antidepresan yan etkisi

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