A Review on Renal Ischemia and Reperfusion Injury

Year 2017, Volume: 39 Issue: 3, 115 - 124, 21.09.2017

Abdullah Ortadeveci , Semih Öz

https://doi.org/10.20515/otd.326630

Abstract

Abstract: Kidney disease is one of the outstanding types of
diseases that have reduced the quality of life of people in recent years. In
particular, damage induced by ischemia-reperfusion leads to varying results,
ranging from renal dysfunction to chronic renal failure. Many conditions, such
as sepsis, shock, hydronephrosis, open kidney surgery, partial nephrectomy,
renal transplantation, or nephron-sparing surgical procedures for renal tumors,
may cause ischemic injury in the kidneys. Therefore, many studies are currently
under way to reduce and prevent ischemia-reperfusion injury in the kidney. In
that studies, attempts have been made to try various methods from the changes
of ischemia or reperfusion until the use before or after ischemia-reperfusion
of medicines that may be effective in treatment. In this study, we tried to
give a general overview of ischemia-reperfusion. Because we can fully
understand the complex cellular events that take place from the onset of
ischemia to the time of acute or chronic damage can give us new perspectives on
the methods to be followed in therapy.

Keywords

ischemia, reperfusion, kidney

Böbrek İskemi-Reperfüzyon Hasarı Üzerine Bir Derleme

Abstract

Öz: Böbrek hastalıkları son yıllarda insanların
yaşam kalitesini düşüren hastalık tipleri arasında önde gelenlerden birisidir.
Özellikle iskemi-reperfüzyon tarafından indüklenen hasar, böbrekteki fonksiyon
bozukluklarından kronik böbrek yetmezliğine kadar değişebilen sonuçlara yol
açmaktadır. Sepsis, şok, hidronefroz, açık böbrek ameliyatları, parsiyel
nefrektomi, renal transplantasyon veya renal tümörler için nefron koruyucu
cerrahi girişimler gibi bir çok durum böbreklerde iskemik hasara sebep
olabilir. Bu yüzden halen böbrekte iskemi-reperfüzyon hasarını azaltmak ve
engellemek için pek çok çalışma yürütülmektedir. Bu çalışmalarda iskemi’nin
veya reperfüzyon’un süresindeki değişikliklerden, tedavide etkili olabilecek
ilaçların iskemi-reperfüzyon öncesi ya da sonrası kullanımlarına kadar pek çok
yöntem denenerek sonuç elde edilmeye çalışılmaktadır. Bizde bu çalışmada
iskemi-reperfüzyon üzerine genel bir özet çıkarmaya çalıştık. Çünkü iskeminin
başlangıcından akut ya da kronik hasarlar oluşuncaya kadar geçen süreçteki
karmaşık hücresel olayları tam olarak kavramak tedavide izlenilecek yöntemler
hakkında bize yeni bakış açıları kazandırabilir.

Keywords

İskemi, reperfüzyon, böbrek, hastalık

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