Comparison of Clinical and Pathologic Outcomes and Between Patients With Stage II Colon Cancer Who Did And Did Not Receive Postoperative Adjuvant Chemotherapy

Year 2018, Volume: 40 Issue: 1, 64 - 70, 27.02.2018

Betül Aydın Buyruk , Özden Altundağ

https://doi.org/10.20515/otd.334985

Abstract

The aim of
this study is to compare clinical and pathologic outcomes and survival between
patients with stage II colon cancer who did and did not receive postoperative
adjuvant chemotherapy. A retrospective examination was made of the records of
patients with stage II colon cancer who underwent surgery and followed up in
our clinic. Patients were compared with regards to several clinicopathological
features such as age, sex, tumor size and stage, number of nodes retrieved, the
presence of lymphovascular invasion, 
tumor localization, signs of intestinal perforation or obstruction at
presentation, disease-free and overall survival rates. A total of 57 patients
with stage II colon cancer were included in the study. Overall 43 (%75, 4)
patients received postoperative adjuvant chemotherapy and the remainder [n=14
(%24,6)] underwent curative surgery alone. Of the patients with a diagnosis of
T4 lesion (n=26), 23 (%53, 5) received postoperative adjuvant chemotherapy. The
presence of T4 lesion was found to be significantly associated with recurrence
(p: 0.015) but not with overall survival (p: 0, 89). Neither the clinical nor
the pathologic features of patients who received chemotherapy were
significantly associated with survival or recurrence. Patients  with stage II colon cancer should be treated
with the treatment of individual characteristics.

Keywords

Stage II colon cancer

Cerrahi Tedavi Sonrası Adjuvan Kemoterapi Alan ve Almayan Evre II Kolon Kanserli Hastaların Klinik ve Patolojik Özelliklerinin Karşılaştırılması

Abstract

Bu çalışmanın amacı,
evre II kolon kanseri nedeniyle postoperatif adjuvan kemoterapi alan ve almayan
hastalar arasındaki klinik ve patolojik özellikleri ve sağkalımı
karşılaştırmaktır. Evre II kolon kanseri nedeniyle opere edilen ve kliniğimizde
takip edilen hastaların kayıtları retrospektif olarak incelendi. Hastalar yaş,
cinsiyet, tümör boyutu ve evresi, alınan lenf nodu sayısı, lenfovasküler
invazyon varlığı, tümör lokalizasyonu, tanı sırasındaki bağırsak perforasyonu
veya obstrüksiyon bulguları, hastalıksız ve genel sağkalım oranları gibi
çeşitli klinikopatolojik özellikler bakımından karşılaştırıldı. Evre II kolon
kanseri olan toplam 57 hasta çalışma kapsamına alındı. Toplam 43 (% 75,4)
hastaya ameliyat sonrası adjuvan kemoterapi, kalan 14 hastaya (% 24,6) sadece
küratif cerrahi uygulandı. .  T4 lezyonlu
(n = 26) hastaların 23'ünde (% 53,5) postoperatif adjuvan kemoterapi uygulandı.
T4 lezyon varlığının rekürrens üzerine etkisi istatiksel olarak anlamlı bulundu
(p = 0.015).Ancak genel sağkalıma etkisi saptanmadı (p = 0.89). Kemoterapi alan
hastaların klinik veya patolojik özellikleri, sağkalım veya rekürrens ile
anlamlı şekilde ilişkili bulunmamıştır. . Evre II kolon kanserli hastaların
tedavi alıp almamasına bireysel özelliklerin değerlendirilmesiyle karar
verilmelidir.

Keywords

Evre II Kolon Kanser, Postoperatif adjuvan kemoterapi

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