Immediate-Type Systemic Hypersensitivity Reactions After the Inactivated SARS-CoV-2 Vaccine in Healthcare Workers

Year 2022, Volume: 44 Issue: 1, 53 - 60, 14.01.2022

Pamir Çerçi , Anıl Uçan

https://doi.org/10.20515/otd.948570

Abstract

The vaccines developed for Coronavirus disease 2019 (COVID-19) not only brought hope to the struggle against the pandemic but also raised questions about hypersensitivity reactions that might occur. Although some studies regarding these concerns with mRNA COVID-19 vaccines have been published, these data on inactivated Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccine are not available. The objective of this study was to determine the safety of the inactivated SARS-CoV-2 vaccine manufactured by Sinovac by evaluating the reported systemic immediate hypersensitivity reactions (IHRs) after the administration of the vaccine to healthcare workers (HCWs). This was a retrospective analysis of inactivated SARS-CoV-2 vaccine recipients in all HCWs vaccinated at our center. Relevant data of all patients who received the vaccine were collected from the electronic medical records available at our center’s database. A statistical analysis of subjects who reported acute adverse reactions was conducted. Of the 3354 HCWs vaccinated with the first dose (female 59.9%, pre-existing allergic disorder 2.4%), four acute adverse reactions (0.12%) met the definition of a systemic IHRs were reported, and only one was confirmed to be anaphylaxis. One out of these four cases received her second dose through graded administration. For the second dose, no systemic reaction was reported in our study population. Inactivated SARS-CoV-2 vaccine appears to be well tolerated in HCWs without any pre-existing allergic disorders.

Keywords

Allergy, COVID-19, Vaccine, Hypersensitivity, Turkey, CoronaVac

Supporting Institution

N/A

Thanks

We express our sincere gratitude to all the doctors, nurses, and personnel of Eskisehir City Hospital involved in vaccination for doing their duties devotedly. We also thank Muzaffer Bilgin, Ph.D., for statistical analyses, Resat Kendirlinan, MD, for graphic presentations, and Sevim Bavbek, Prof. MD, for her gracious review of our manuscript.

Sağlık Çalışanlarında İnaktive SARS-CoV-2 Aşısı Sonrası Gelişen Ani Tip Sistemik Aşırı Duyarlılık Reaksiyonları

Abstract

Koronavirüs hastalığı 2019 (COVID-19) için geliştirilen aşılar, pandemi ile mücadelede umut ışığı sağlarken bir yandan da oluşabilecek aşırı duyarlılık reaksiyonları hakkında soru işaretlerini de beraberinde getirmiştir. Yeni mRNA COVID-19 aşıları ile ilgili bu endişelere ilişkin bazı çalışmalar yayınlanmış olsa da inaktive Şiddetli Akut Solunum Yolu Sendromu Koronavirüs 2 (SARS-CoV-2) aşıları ile ilgili veriler yaygın değildir. Bu çalışmanın amacı, aşının sağlık çalışanlarına uygulanmasından sonra bildirilen sistemik ani aşırı duyarlılık reaksiyonlarını (ADR'ler) değerlendirerek Sinovac tarafından üretilen inaktive SARS-CoV-2 aşısının güvenliğini belirlemektir. Merkezimizde inaktive SARS-CoV-2 aşısı ile aşılanan tüm sağlık çalışanlarını retrospektif olarak inceledik. Aşı yapılan tüm hastaların ilgili verileri merkezimizin veri tabanında bulunan elektronik tıbbi kayıtlardan toplanmıştır. Akut advers reaksiyonlar bildiren deneklerin istatistiksel bir analizi yapılmıştır. İlk dozla aşılanan 3354 sağlık çalışanından (kadın %59,9, önceden var olan alerjik durum %2,4), sistemik ani tip aşırı duyarlılık reaksiyonu tanımını karşılayan dört akut advers reaksiyon (%0,12) bildirilmiştir. Sadece birinin anafilaksi olduğu doğrulanmıştır. Bu dört vakadan biri ikinci dozunu dereceli uygulama yoluyla almıştır. İkinci doz için, çalışma popülasyonumuzda herhangi bir sistemik reaksiyon bildirilmemiştir. İnaktive edilmiş SARS-CoV-2 aşısı, önceden herhangi bir alerjik hastalığı olmayan sağlık çalışanlarında iyi tolere edilmiş gibi görünmektedir.

Keywords

Alerji, COVID-19, Aşı, Aşırı Duyarlılık, Turkey, CoronaVac

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