Correlation of Systemic Inflammatory Index and Neutrophil Platelet Ratio with Intracranial Haemorrhage and Mortality After Endovascular Treatment Due to Acute Ischaemic Stroke

Year 2024, Volume: 46 Issue: 4, 510 - 520, 16.07.2024

Firdevs Ezgi Uçan Tokuç , Şennur Delibaş Katı

https://doi.org/10.20515/otd.1463965

Abstract

Many studies in recent years have shown that systemic and local inflammatory responses following various diseases are important markers of tissue damage. We aimed to investigate the correlation of systemic inflamatory index and neutrophil platelet ratio with intracranial haemorrhage and mortality in patients undergoing endovascular treatment due to ischaemic stroke. Between 2022 and 2024, patients who hospitalised in the Antalya Training and Research Hospital Neurology intensive care unit after endovascular treatment were screened. Patients over 18 years of age with a door-needle time of less than 24 hours and who underwent endovascular treatment for successful internal carotid artery ICA, MCA, and basilar artery occlusion due to acute ischaemic stroke were included in the study. A total of 133 patients were included. intracranial haemorrhage was observed in 59 (44.4%) patients, and exitus developed in 38 (28.6%) patients. There was a correlation between the development of intracranial haemorrhage and systemic inflamatory index and neutrophil platelet ratio. A statistically significant difference was observed between the neutrophil platelet ratio and systemic inflamatory index median values according to mortality status, and neutrophil platelet ratio values were higher in patients who developed exitus. In conclusion, our findings indicate the correlation of systemic inflamatory index and neutrophil platelet ratio independently with intracranial haemorrhage and mortality in patients with endovascular treatment. These noninvasive and cost-effective inflammatory markers may constitute a good biomarker for intracranial haemorrhage and mortality after endovascular treatment. In order to confirm these findings, prospective studies with a larger population of patients are needed.

Keywords

Acute İschaemic Stroke, Endovascular Treatment, Intracranial Haemorrhage, Systemic Inflammatory Index, Neutrophil Platelet Ratio

Sistemik İnflamatuar İndeks ve Nötrofil Platelet Oranının Akut İskemik İnme Nedeniyle Endovasküler Tedavi Sonrası İntrakranial Hemaroji Ve Mortaliteyle İlişkisi

Abstract

Son yıllarda yapılan birçok çalışma, çeşitli hastalıkları takiben oluşan sistemik ve lokal enflamatuar yanıtların doku hasarının önemli belirteçleri olduğunu göstermiştir. Bu çalışmada iskemik inme nedeniyle endovasküler tedavi uygulanan hastalarda sistemik inflamatuvar indeks ve nötrofil platelet oranının intrakranial hemoraji ve mortalite ile ilişkisini araştırmayı amaçladık. 2022-2024 yılları arasında Antalya Eğitim ve Araştırma Hastanesi Nöroloji yoğun bakım ünitesinde endovasküler tedavi sonrası yatan hastalar tarandı. Akut iskemik inme nedeniyle başarılı ICA, MCA ve baziler arter oklüzyonu için endovasküler tedavi uygulanan ve kapı-iğne süresi 24 saatten az olan 18 yaşından büyük hastalar çalışmaya dahil edildi. Toplam 133 hasta çalışmaya dahil edildi. 59 (%44,4) hastada intrakranial kanama gözlendi ve 38 (%28,6) hastada exitus gelişti. İntrakranial hemoraji gelişimi ile sistemik inflamatuvar indeks ve nötrofil trombosit oranı arasında korelasyon vardı. Mortalite durumuna göre nötrofil platelet oranı ve sistemik inflamatuvar indeks medyan değerleri arasında istatistiksel olarak anlamlı bir fark gözlendi ve exitus gelişen hastalarda nötrofil platelet oranı değerleri daha yüksekti. Bulgularımız endovasküler tedavi uygulanan hastalarda sistemik inflamatuvar indeks ve nötrofil platelet oranının bağımsız olarak intrakranial hemoraji ve mortalite ile ilişkili olduğunu göstermektedir. Bu noninvaziv ve uygun maliyetli inflamatuvar belirteçler, endovasküler tedavi sonrası intrakranial kanama ve mortalite için iyi bir biyobelirteç olabilir. Bu bulguları doğrulamak için daha geniş bir hasta popülasyonuyla yapılacak prospektif çalışmalara ihtiyaç vardır.

Keywords

Akut iskemik İnme, Endovaskuler Tedavi, İntrakranial Hemoraji, Sistemik İnflamatuar İndeks, Nötrofil Platelet Oranı

Ethical Statement

No conflict of interest was declared by the authors.

Supporting Institution

The authors declared that this study received no financial support.

Thanks

None

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