Romatoid Artritli Hastalar ile Sağlıklı Kontroller Arasında Serum Nesfatin-1 ve Visfatin Düzeylerinin Karşılaştırılması

Year 2024, Volume: 46 Issue: 6, 967 - 971, 07.11.2024

Sercan Gücenmez , Mustafa Özmen , Dilek Solmaz , Önay Gerçik , Ahmet Toygar Kalkan , Didem Kozaci , Servet Akar

https://doi.org/10.20515/otd.1494557

Abstract

Romatoid artritli (RA) hastalarda nesfatin-1 düzeylerinin yükseldiği daha önce bildirilmiş olmasına rağmen vücut kütle indeksinin (BMI) olası rolü dışlanmamıştır. Bu çalışmanın amacı BMI değerleri normal (18,50,05). RA hastalarında nesfatin-1 düzeylerinin sağlıklı yaşıtlarına göre anlamlı derecede yüksek olduğu görülmektedir. Ancak nesfatin-1 düzeylerinin hastalık aktivitesiyle ilişkisi saptanamadı.

Keywords

Adipokinler, artrit, vücut kütle indeksi

Comparison of Serum Nesfatin-1 and Visfatin Levels Between Patients with Rheumatoid Arthritis and Healthy Controls

Abstract

Even though elevated nesfatin-1 levels were reported in patients with rheumatoid arthritis (RA) previously, the possible role of body mass index (BMI) was not excluded. The aim of the present study was to compare serum nesfatin-1 and visfatin levels between patients with RA and healthy controls who have normal BMI values (18.50.05). It seems that nesfatin-1 levels are significantly higher in RA patients compared to healthy peers. However, nesfatin-1 levels were not found related to disease activity.

Keywords

Adipokines, arthritis, body mass index

References

• 1. van der Woude D, van der Helm-van Mil AHM. Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis. Best Pract Res Clin Rheumatol 2018;32:174-87.
• 2. Burmester GR, Feist E, Dörner T. Emerging cell and cytokine targets in rheumatoid arthritis. Nat Rev Rheumatol 2014;10:77-88.
• 3. Lee YH, Bae SC. Circulating adiponectin and visfatin levels in rheumatoid arthritis and their correlation with disease activity: A meta-analysis. Int J Rheum Dis 2018;21:664-72.
• 4. Adeghate E. Visfatin: structure, function and relation to diabetes mellitus and other dysfunctions. Curr Med Chem 2008;15:1851-62.
• 5. Carrión M, Frommer KW, Pérez-García S, Müller-Ladner U, Gomariz RP, Neumann E. The adipokine network in rheumatic joint diseases. Int J Mol Sci 2019;20:4091.
• 6. Miura K, Titani K, Kurosawa Y, Kanai Y. Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine zipper structure. Biochem Biophys Res Commun 1992;187:375-80.
• 7. Barnikol-Watanabe S, Gross NA, et al. Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein. Biol Chem Hoppe Seyler 1994;375:497-512.
• 8. Oh-I S, Shimizu H, Satoh T, et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006;443:709-12.
• 9. Jiang L, Bao J, Zhou X, Xiong Y, Wu L. Increased serum levels and chondrocyte expression of nesfatin-1 in patients with osteoarthritis and its relation with BMI, hsCRP, and IL-18. Mediators Inflamm 2013;2013:631251.
• 10. Zhang Y, Shui X, Lian X, Wang G. Serum and synovial fluid nesfatin-1 concentration is associated with radiographic severity of knee osteoarthritis. Med Sci Monit 2015;21:1078-782.
• 11. Scotece M, Conde J, Abella V, et al. NUCB2/nesfatin-1: a new adipokine expressed in human and murine chondrocytes with pro-inflammatory properties, an in vitro study. J Orthop Res 2014;32:653-60.
• 12. Aletaha D, Neogi T, Silman AJ, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010;62:569-81.
• 13. Leivo-Korpela S, Lehtimäki L, Hämälainen M, et al. Adipokines NUCB2/nesfatin-1 and visfatin as novel inflammatory factors in chronic obstructive pulmonary disease. Mediators Inflamm 2014;2014:232167.
• 14. Robinson C, Tsang L, Solomon A, et al. Nesfatin-1 and visfatin expression is associated with reduced atherosclerotic disease risk in patients with rheumatoid arthritis. Peptides 2018;102:31-7.
• 15. Kvlividze TZ, Zavodovsky BV, Akhverdyan YR, et al. Serum nesfatin-1 as a marker of systemic inflammation in rheumatoid arthritis. Klin Lab Diagn 2019;64:53-6.
• 16. Naghashian F, Hosseinzadeh-Attar MJ, Akhlaghi M, Yekaninejad MS, Aryaeian N, Derakhshanian H. The relationship between anthropometric status and rheumatoid arthritis. Exploring the role of nesfatin and asymmetric dimethylarginine. Acta Reumatol Port 2019;44:126-31.