Amantadin İnfüzyonunun Travmatik Beyin Hasarında Etkisi

Year 2020, Volume: 5 Issue: 1, 155 - 164, 31.03.2020

Ayça Sultan Şahin , Süreyya Özkan

https://doi.org/10.26453/otjhs.613102

Abstract

Amaç: Travmatik Beyin Hasarı (TBH), önemli bir sosyoekonomik ve halk sağlığı sorunudur. Amantadin sülfat nöroprotektif olarak kullanılan bir ilaçtır. Bu çalışmada, amantadin infüzyon tedavisinin, ciddi kafa travması olan hastalarda bilincin geri dönmesine pozitif etkisini araştırmayı amaçladık.
Materyal ve Metot: TBH olan hastalar, amantadin infüzyonu kullanma durumarına göre iki gruba ayrıldı. Grup I (n=40): amantadin infüzyonu kullanan grup ve Grup II (n=40): amantadin infüzyonu kullanmayan grup. Hastaların yaşları, cinsiyetleri, Glasgow Koma Skalası (GKS), eğitim seviyeleri, yoğun bakım ünitesine geldiğinde entübe olup olmadıkları, bilincin geri dönüş zamanı, taburculuk zamanı ve BT veya MR sonuçları ve Coma Recovery Scale–Revised (CRS-R) skoru retrospektif olarak kaydedildi.
Bulgular: Bilincin geri dönüş zamanı Grup I de istatistiksel olarak belirgin olarak daha kısaydı. Hastaların eğitim düzeyleri arasında istatistiksel olarak anlamlı bir fark saptanmadı. Grup I de hastaların yoğun bakıma kabulü sırasında GKS daha düşüktü. Fonksiyonel nesne kullanımı ve uzun dönemli dikkat Grup I de CRS-R’ye göre daha yüksekti.
Sonuç: Bu çalışmaya göre, amantadin infüzyonu nörolojik iyileşmeyi ve nörokognitif fonksiyonları olumlu yönde etkilemektedir.

Keywords

Hasar, Beyin, Amantadin infüzyonu, travmatik

Effect of Amantadine Infusion on Traumatic Brain Injury

Abstract

Objective: Traumatic brain injury (TBI) is a significant socioeconomic and public health problem. Amantadine sulfate has been used as a neuroprotective drug. In this study, We aim that amantadine infusion treatment effects positively in patients with a severe head injury on conscious recovery. 

Materials and Methods: Patients with TBI were classified into two groups: Patients that used amantadine infusion group was Group I (n=40) and patients that not used amantadine infusion group was Group group II (n=40). Age, gender, Glasgow Coma Scale (GCS), education level, intubated or non-intubated when he/she come to Intensive Care Unit (ICU), the recovery time of conscious, discharge time, recovery of CT or MR scan and Coma Recovery Scale-Revised (CRS-R) were retrospectively recorded. 

Results: Time to recovery in consciousness was statistically significant shorter in group I. There were no statistically significant differences between the educational status of patients. The GCS of patients, when admitted to ICU, was lower in group I. Functional object use and long-term attention were have higher scores in group I when compared to CRS-R.

Conclusion: Amantadine infusion affects positively neurological recovery and neurocognitive function for TBI in this study.

Keywords

Amantadine ınfusion, brain, ınjury, traumatic

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