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Canlı Donörden Böbrek Nakli: İlk Deneyimlerimiz

Year 2020, Volume: 5 Issue: 2, 356 - 363, 30.06.2020
https://doi.org/10.26453/otjhs.705092

Abstract

Amaç: Son dönem böbrek yetmezliği belirgin morbidite ve mortalite ile toplumda oldukça yaygındır. Böbrek yetmezliği olan hastalarda, yaşam kalitesini ve sağ kalımı arttırdığı için böbrek nakli etkin bir tedavi seçeneğidir. Bu çalışmanın amacı yeni hizmete giren böbrek nakil merkezindeki ilk sonuçları değerlendirmektir.
Materyal ve Metot: Nisan 2019 ile Ekim 2019 tarihleri arasında, Sakarya Üniversitesi Eğitim Araştırma Hastanesi Böbrek Nakil Merkezi’nde böbrek yetmezliği nedeniyle nakil yapılan 20 hasta retrospektif olarak değerlendirildi. Hastaların ve donörlerin demografik özellikleri kaydedildi ve operasyon öncesi ve sonrası laboratuvar sonuçları değerlendirildi. Posttransplantasyon akut komplikasyonları kaydedildi. Verileri uygun istatistik yöntemi (ortalama ±standart sapma ve ortanca(min,max)) ile değerlendirildi.
Bulgular: Böbrek alıcıların ortalama yaşı 46,10±11,52 yıl, Vucut kitle indeksi (VKİ) 27,00±6,00 idi ve %40’ı kadın %60’ı erkekti. Nakil yapılan hastaların operasyon sonrası ortalama serum kreatinin 1.gün:3,10±1,60 mg/dl, 7.gün:1,17±0,36 mg/dl, 3.ay:1,07±0,26 mg/dl, 6. Ay:1,10±0,28 mg/dl idi.
Sonuç: Son dönem böbrek yetmezliği olan hastalığı olan hastalarda yapılan böbrek nakil operasyonu kısa dönem sonuçlarının başarılı olduğu görülmektedir. Laparoskopik donör nefrektomi uygun vericilerde ilk tercih edilmesi gereken yaklaşımdır. Son dönem böbrek yetmezliği olan hastalara mümkün olduğunca böbrek nakli gerçekleştirilmesi hem hasta sağ kalımı hem de ekonomik maliyet açısından önerilen tedavi yöntemdir. 

References

  • 1. Arogundade FA, Abd-Essamie MA, Barsoum RS. Health-related quality of life in emotionally related kidney transplantation: deductions from a comparative study. Saudi J Kidney Dis Transpl. 2005;16(3):311-320.
  • 2. Garcia Garcia G, Harden P, Chapman J. The global role of kidney transplantation. Arab J Nephrol Transplant. 2012;81(5):425-427. doi:10.1097/MOT.0b013e328354c277
  • 3. Tullius SG, Rabb H. Improving the supply and quality of deceased-donor organs for transplantation. N Engl J Med. 2018;378(20):1920-1929. doi:10.1056/NEJMra1507080
  • 4. Brown SL, Biehl TR, Rawlins MC, Hefty TR. Laparoscopic live donor nephrectomy: A comparison with the conventional open approach. J Urol. 2001;165(3):766-769. doi:10.1016/S0022-5347(05)66521-4
  • 5. Flowers JL, Jacobs S, Cho E, et al. Comparison of open and laparoscopic live donor nephrectomy. Ann Surg. 1997;226(4):483-489. doi:10.1097/00000658-199710000-00009
  • 6. Hiller J, Sroka M, Holochek MJ, Morrison A, Kavoussi LR, Ratner LE. Functional advantages of laparoscopic live-donor nephrectomy compared with conventional open-donor nephrectomy. J Transpl Coord. 1997;7(3):134-140. doi:10.7182/prtr.1.7.3.v503420j4hr31621
  • 7. Arze Aimaretti L, Arze S. Preemptive Renal Transplantation - The Best Treatment Option for Terminal Chronic Renal Failure. Transplant Proc. 2016;48(2):609-611. doi:10.1016/j.transproceed.2016.02.047
  • 8. Arogundade FA. Kidney transplantation in a low-resource setting: Nigeria experience. Kidney Int Suppl. 2013;3(2):241-245. doi:10.1038/kisup.2013.23
  • 9. Tasaki M, Saito K, Nakagawa Y, et al. 20-year analysis of kidney transplantation: A single center in Japan. Transplant Proc. 2014;46(2):437-441. doi:10.1016/j.transproceed.2013.10.052
  • 10. Kinnunen S, Karhapää P, Juutilainen A, Finne P, Helanterä I. Secular trends in infection-related mortality after kidney transplantation. Clin J Am Soc Nephrol. 2018;13(5):755-762. doi:10.2215/CJN.11511017
  • 11. Yalci A, Celebi ZK, Ozbas B, et al. Evaluation of Infectious Complications in the First Year after Kidney Transplantation. Transplant Proc. 2015;47(5):1429-1432. doi:10.1016/j.transproceed.2015.04.056
  • 12. Harris AD, Fleming B, Bromberg JS, et al. Surgical Site Infection after Renal Transplantation. Infect Control Hosp Epidemiol. 2015;36(4):417-423. doi:10.1017/ice.2014.77
  • 13. Takemoto S, Port FK, Claas FHJ, Duquesnoy RJ. HLA matching for kidney transplantation. Hum Immunol. 2004;65(12):1489-1505. doi:10.1016/j.humimm.2004.06.008
  • 14. Roake JA, Cahill AP, Gray CM, Gray DWR, Morris PJ. Preemptive cadaveric renal transplantation - Clinical outcome. Transplantation. 1996;62(10):1411-1416. doi:10.1097/00007890-199611270-00006
  • 15. Lim WH, Clayton P, Wong G, et al. Outcomes of kidney transplantation from older living donors. Transplantation. 2013;95(1):106-113. doi: 10.1097/TP.0b013e318277b2be
  • 16. Noppakun K, Cosio FG, Dean PG, Taler SJ, Wauters R, Grande JP. Living donor age and kidney transplant outcomes. Am J Transplant. 2011;11(6):1279-1286. doi: 10.1111/j.1600-6143.2011.03552.x
  • 17. Ghafari A. Offspring-to-Mother and Husband-to-Wife Renal Transplantation: A Single-Center Experience. Transplant Proc. 2008;40(1):140-142. doi: 10.1016/j.transproceed.2007.11.062
  • 18. Calne RY, Thiru S, McMaster P, et al. Cyclosporin a in patients receiving renal allografts from cadaver donors. J Am Soc Nephrol. 1998;9(9):1751-1756. doi: 10.1016/S0140-6736(78)91970-0
  • 19. Jensik SC. Tacrolimus (FK 506) in kidney transplantation: Three-year survival results of the US Multicenter, randomized, comparative trial. Transplant Proc. 1998;30(4):1216-1218. doi: 10.1016/S0041-1345(98)00216-4
  • 20. Sollinger HW, Deierhoi MH, Belzer FO, Diethelm AG, Kauffman RS. Rs-61443—a phase i clinical trial and pilot rescue study. Transplantation. 1992;53(2):428-432. doi: 10.1097/00007890-199202010-00031
  • 21. Dominguez J, Clase CM, Mahalati K, et al. Is routine ureteric stenting needed in kidney transplantation? A randomized trial. Transplantation. 2000;70(4):597-601. doi: 10.1097/00007890-200008270-00011
  • 22. Sözen H, Özen O, Fidan K, Söylemezoğlu O, Dalgıç A. Outcome of the Double-J Stent Placement in Pediatric Kidney Transplant: A Single Center Experience. Exp Clin Transplant. 2017;1(1):1. doi: 10.6002/ect.2016.0280

Renal Tranplantation in Living Kidney Donors: First Experiences

Year 2020, Volume: 5 Issue: 2, 356 - 363, 30.06.2020
https://doi.org/10.26453/otjhs.705092

Abstract

Objective: End-stage renal failure is quite common in the community with pronounced morbidity and mortality. Kidney transplantation is an effective treatment option in patients with renal insufficiency as it improves quality of life and survival. The aim of this study is to evaluate the first results in currently introduced kidney transplant center.
Materials and Methods: Between April 2019 and October 2019, 20 patients who were transplanted due to kidney failure at the Sakarya University Training and Research Hospital Kidney Transplant Center were evaluated retrospectively. The demographic characteristics of the patients and donors were recorded and the laboratory results before and after the operation were evaluated. Acute complications of posttransplantation were recorded. The data were evaluated by appropriate statistical method (overall ± standard deviation and median (min, max)).
Results: The average age of kidney recipients was 46.10 ± 11.52 years, BMI was 27.00 ± 6.00, and 40% were female and 60% were male. Average serum creatinine after the operation of patients who were transplanted 1.day: 3.10 ± 1.60 mg / dl, 7.day: 1,17±0,36 mg / dl, 3.month: 1,07±0,26 mg / dl, 6th month: 1,10±0,28 mg / dl.
Conclusion: The short-term results of kidney transplantation performed in patients with end-stage renal failure appear to be successful. Laparoscopic donor nephrectomy is the first choice approach in appropriate donors. Performing kidney transplantation as much as possible to patients with end-stage renal failure is the recommended treatment method in terms of both patient survival and economic costs.

References

  • 1. Arogundade FA, Abd-Essamie MA, Barsoum RS. Health-related quality of life in emotionally related kidney transplantation: deductions from a comparative study. Saudi J Kidney Dis Transpl. 2005;16(3):311-320.
  • 2. Garcia Garcia G, Harden P, Chapman J. The global role of kidney transplantation. Arab J Nephrol Transplant. 2012;81(5):425-427. doi:10.1097/MOT.0b013e328354c277
  • 3. Tullius SG, Rabb H. Improving the supply and quality of deceased-donor organs for transplantation. N Engl J Med. 2018;378(20):1920-1929. doi:10.1056/NEJMra1507080
  • 4. Brown SL, Biehl TR, Rawlins MC, Hefty TR. Laparoscopic live donor nephrectomy: A comparison with the conventional open approach. J Urol. 2001;165(3):766-769. doi:10.1016/S0022-5347(05)66521-4
  • 5. Flowers JL, Jacobs S, Cho E, et al. Comparison of open and laparoscopic live donor nephrectomy. Ann Surg. 1997;226(4):483-489. doi:10.1097/00000658-199710000-00009
  • 6. Hiller J, Sroka M, Holochek MJ, Morrison A, Kavoussi LR, Ratner LE. Functional advantages of laparoscopic live-donor nephrectomy compared with conventional open-donor nephrectomy. J Transpl Coord. 1997;7(3):134-140. doi:10.7182/prtr.1.7.3.v503420j4hr31621
  • 7. Arze Aimaretti L, Arze S. Preemptive Renal Transplantation - The Best Treatment Option for Terminal Chronic Renal Failure. Transplant Proc. 2016;48(2):609-611. doi:10.1016/j.transproceed.2016.02.047
  • 8. Arogundade FA. Kidney transplantation in a low-resource setting: Nigeria experience. Kidney Int Suppl. 2013;3(2):241-245. doi:10.1038/kisup.2013.23
  • 9. Tasaki M, Saito K, Nakagawa Y, et al. 20-year analysis of kidney transplantation: A single center in Japan. Transplant Proc. 2014;46(2):437-441. doi:10.1016/j.transproceed.2013.10.052
  • 10. Kinnunen S, Karhapää P, Juutilainen A, Finne P, Helanterä I. Secular trends in infection-related mortality after kidney transplantation. Clin J Am Soc Nephrol. 2018;13(5):755-762. doi:10.2215/CJN.11511017
  • 11. Yalci A, Celebi ZK, Ozbas B, et al. Evaluation of Infectious Complications in the First Year after Kidney Transplantation. Transplant Proc. 2015;47(5):1429-1432. doi:10.1016/j.transproceed.2015.04.056
  • 12. Harris AD, Fleming B, Bromberg JS, et al. Surgical Site Infection after Renal Transplantation. Infect Control Hosp Epidemiol. 2015;36(4):417-423. doi:10.1017/ice.2014.77
  • 13. Takemoto S, Port FK, Claas FHJ, Duquesnoy RJ. HLA matching for kidney transplantation. Hum Immunol. 2004;65(12):1489-1505. doi:10.1016/j.humimm.2004.06.008
  • 14. Roake JA, Cahill AP, Gray CM, Gray DWR, Morris PJ. Preemptive cadaveric renal transplantation - Clinical outcome. Transplantation. 1996;62(10):1411-1416. doi:10.1097/00007890-199611270-00006
  • 15. Lim WH, Clayton P, Wong G, et al. Outcomes of kidney transplantation from older living donors. Transplantation. 2013;95(1):106-113. doi: 10.1097/TP.0b013e318277b2be
  • 16. Noppakun K, Cosio FG, Dean PG, Taler SJ, Wauters R, Grande JP. Living donor age and kidney transplant outcomes. Am J Transplant. 2011;11(6):1279-1286. doi: 10.1111/j.1600-6143.2011.03552.x
  • 17. Ghafari A. Offspring-to-Mother and Husband-to-Wife Renal Transplantation: A Single-Center Experience. Transplant Proc. 2008;40(1):140-142. doi: 10.1016/j.transproceed.2007.11.062
  • 18. Calne RY, Thiru S, McMaster P, et al. Cyclosporin a in patients receiving renal allografts from cadaver donors. J Am Soc Nephrol. 1998;9(9):1751-1756. doi: 10.1016/S0140-6736(78)91970-0
  • 19. Jensik SC. Tacrolimus (FK 506) in kidney transplantation: Three-year survival results of the US Multicenter, randomized, comparative trial. Transplant Proc. 1998;30(4):1216-1218. doi: 10.1016/S0041-1345(98)00216-4
  • 20. Sollinger HW, Deierhoi MH, Belzer FO, Diethelm AG, Kauffman RS. Rs-61443—a phase i clinical trial and pilot rescue study. Transplantation. 1992;53(2):428-432. doi: 10.1097/00007890-199202010-00031
  • 21. Dominguez J, Clase CM, Mahalati K, et al. Is routine ureteric stenting needed in kidney transplantation? A randomized trial. Transplantation. 2000;70(4):597-601. doi: 10.1097/00007890-200008270-00011
  • 22. Sözen H, Özen O, Fidan K, Söylemezoğlu O, Dalgıç A. Outcome of the Double-J Stent Placement in Pediatric Kidney Transplant: A Single Center Experience. Exp Clin Transplant. 2017;1(1):1. doi: 10.6002/ect.2016.0280
There are 22 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Research article
Authors

Necattin Fırat 0000-0003-0684-8187

Hamad Dheir 0000-0002-3569-6269

Emrah Akın This is me 0000-0003-0224-3834

Savaş Sipahi 0000-0001-6829-121X

Fatih Altıntoprak 0000-0002-3939-8293

Fehmi Çelebi 0000-0003-1157-8556

Mertcan Akçay This is me 0000-0003-3513-292X

Publication Date June 30, 2020
Submission Date March 17, 2020
Acceptance Date May 11, 2020
Published in Issue Year 2020 Volume: 5 Issue: 2

Cite

AMA Fırat N, Dheir H, Akın E, Sipahi S, Altıntoprak F, Çelebi F, Akçay M. Canlı Donörden Böbrek Nakli: İlk Deneyimlerimiz. OTJHS. June 2020;5(2):356-363. doi:10.26453/otjhs.705092

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