Non Alkolik Yağlı Karaciğer Hastalığı ile Yaş, Cinsiyet ve İnsülin Direnci İlişkisinin Araştırılması

Year 2021, Volume: 6 Issue: 2, 291 - 299, 05.06.2021

Hayrullah Yazar , Ömer Emre Öz , Elif Köse , Alper Karacan , Mustafa Yöntem

https://doi.org/10.26453/otjhs.898531

Abstract

Amaç: Bu çalışmada non-alkolik yağlı karaciğer hastalarında (NAYKH) insülin direnci, yaş ve cinsiyet ilişkisinin araştırılması amaçlanmıştır.
Materyal ve Metot: NAYKH tanılı alkol kullanmayan hastalara ait veriler, bir yıl boyunca kayıt altına alındı. Hastaların NAYKH tanısı 4D ultrason cihazı ile konuldu. Çalışmada tüm hastaların açlık kan şekeri ve açlık insülin hormonu değerleri kullanılarak, insülin dirençleri hesaplandı. Elde edilen verilerin istatistiği “IBM SPSS for Windows Version 20.0 software” programı ile yapıldı ve anlamlılık düzeyi p<0,05 kabul edildi.
Bulgular: Çalışmada; kriterlere uyan 312 erkek ve 558 kadın, toplamda 870 hasta incelendi. Erkeklerde yaş ortalaması 15, kadınlarda 29 bulundu ve bu farkın anlamlı olduğu görüldü. NAYKH görülme sıklığı; erkeklerde %47,75 iken, kadınlarda %33,51 oldu. Yaşa göre NAYKH; çocuklarda %32,57 iken, erişkinlerde %49,28 şeklinde idi. HOMA-IR ortalama değerleri cinsiyete göre; erkeklerde 2,51 ve kadınlarda 2,53 idi. Yaşa göre HOMA-IR ortalama değerleri; çocuklarda 3,14 ve erişkinlerde 2,09 bulundu. HOMA-IR grade guplarına göre incelenince, bu değerlerin grade II ve grade III’te anlamlı olarak arttığı görüldü.
Sonuç: NAYKH, yaş ve cinsiyet arasında ilişki vardır. Şöyle ki; erkeklerde bu hastalık hem sık görülmekte hem de erken yaşta ortaya çıkmaktadır. İlaveten; HOMA-IR’nin çocuklarda daha yüksek çıkması, üzerinde daha geniş çaplı araştırma yapılması gereken bir sonuç olarak görüldü.

Keywords

NAYKH, Homa-IR, 4D doppler usg, yaş, cinsiyet

Investigation of the Relationship between Non-Alcoholic Fatty Liver Disease and Age, Gender and Insulin Resistance

Abstract

Objective: In the study, it was aimed to investigate of insulin resistance, age, and gender relationship in non-alcoholic fatty liver disease (NAFLD).
Materials and Methods: The data of patients diagnosed with NAFLD who did not drink alcohol were recorded for one year. The patients were diagnosed with NAFLD with Doppler USG and divided into three groups. In the study, insulin resistance was calculated using fasting blood glucose and fasting insulin hormone values of all patients. The statistics of the obtained data were made using the program "IBM SPSS for Windows Version 20.0" and the significance level was accepted as p <0.05.
Results: In the study; A total of 870 patients, 312 males and 558 females, who met the criteria were examined. The average age was 15 for males and 29 for females, and this difference was found to be significant. Incidence of NAFLD; While it was 47.75% for men, it was 33.51% for women. NAFLD by age; While it was 32.57% in children, it was 49.28% in adults. HOMA-IR average values; 2.51 in male patients and 2.53 in women. HOMA-IR average values by age; 3.14 in children and 2.09 in adults. When the HOMA-IR values were examined according to the grade groups, it was seen that these values increased significantly in grade II and grade III.
Conclusion: There is a relationship between NAFLD, age and gender. Namely, This disease is common in men and occurs at an early age. Additionally, the higher HOMA-IR in children was seen as a result that should be researched more widely.

Keywords

NAFLD, Homa-IR, 4d doppler usg, age, gender

References

• Ludwig J, Viggiano TR, McGill DB, Oh BJ. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc. 1980;55(7):434-438.
• McCullough A, Bugianesi E, Marchesini G, Kalhan SC. Gender dependent alterations in serum leptin in alcoholic cirrhosis. Gastroenterology. 1998;115:947-953.
• National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106(25):3143-421.
• Wenclewska S, Szymczak-Pajor I, Drzewoski J, Bunk M, Śliwińska A. Vitamin D Supplementation Reduces Both Oxidative DNA Damage and Insulin Resistance in the Elderly with metabolic disorders. Int J Mol Sci. 2019;20(12):2891. doi:10.3390/ijms20122891
• Chacińska M, Zabielski P, Książek M, et al. The Impact of OMEGA-3 fatty acids supplementation on ınsulin resistance and content of adipocytokines and biologically active lipids in adipose tissue of high-fat diet fed rats. Nutrients. 2019;11(4):835. doi:10.3390/nu11040835
• Can M, Duran C, Guney I, Elmas H, Ayhan M, Erdem SS. The relationship between glomerular filtration rate, and metabolic and inflammatory parameters in obese and non-obese patients with polycystic ovary syndrome. Clin Investig Arterioscler. 2020;32(6):256-262. doi:10.1016/j.arteri.2020.04.003
• Şendur R, Özcabı B, Mutlu GY, Bozaykut A. Effective sociodemographic and clinical factors in weight loss in childhood obesity. Turk Pediatri Ars. 2018;53(3):169-176. doi:10.5152/TurkPediatriArs.2018.6210
• Elmaogullari S, Demirel F, Hatipoglu N. Risk factors that affect metabolic health status in obese children. J Pediatr Endocrinol Metab. 2017;30(1):49-55. doi:10.1515/jpem-2016-0128
• Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-9.
• Yazar H, Öz OE, Köse E. Biyokimya laboratuvarında yeni uygulamalar ve klinisyenlerin farkındalığı. Online Türk Sağlık Bilimleri Dergisi. 2019;4(2):170-182. doi:10.26453/otjhs.459641
• Yazar H, Yılmaz ZM, Yıldırım K, Yazar EF, Yazar İO. Systematic perspectives in medicine; halal life medicine, functional medicine, holistic medicine, lifestyle medicine. Journal of Halal Life Medicine. 2019;1(1):01-19.
• Carol M. Rumack, Stephanie R, et.al. Diagnostic Ultrasound. Volume 1 3nd ed. Missouri, St.Louis: Elsevier Mosby. An Affiliate of Elsevier Press; 2005.
• Neuschwander-Tetri BA. Non-alcoholic fatty liver disease. BMC Med. 2017;15(1):45. doi:10.1186/s12916-017-0806-8
• Younossi ZM. Non-alcoholic fatty liver disease - A global public health perspective. J Hepatol. 2019;70(3):531-544. doi:10.1016/j.jhep.2018.10.033
• Bhat G, Baba CS, Pandey A, Kumari N, Choudhuri G. Life style modification improves insulin resistance and liver histology in patients with non-alcoholic fatty liver disease. World J Hepatol. 2012;4(7):209-217. doi:10.4254/wjh.v4.i7.209
• Engin A. Non-alcoholic fatty liver disease. Adv Exp Med Biol. 2017;960:443-467. doi:10.1007/978-3-319-48382-5_19
• Ballestri S, Nascimbeni F, Baldelli E, Marrazzo A, Romagnoli D, Lonardo A. NAFLD as a sexual dimorphic disease: role of gender and reproductive status in the development and progression of nonalcoholic fatty liver disease and ınherent cardiovascular risk. Adv Ther. 2017;34(6):1291-1326. doi:10.1007/s12325-017-0556-1