The Effect of EGFR, P16 and Ki67 Expression on Prognosis in Head and Neck Squamous Cell Carcinoma

Year 2022, Volume: 7 Issue: 2, 196 - 201, 01.06.2022

Sevil Karabağ , Ayşegül İsal Arslan , Tolga Ersözlü

https://doi.org/10.26453/otjhs.1005416

Abstract

Objective: HPV and EGFR expression status may be utilized as an independent prognostic factor owing to the different clinical and demographic characteristics head and neck cancers. In the study, it was aimed to investigate the association between EGFR, p16 and ki67 expression and survival in patients with head and neck squamous cell carcinoma (SCC).

Materials and Methods: A total of 43 patients with SCC of the head and neck region were included in the study. EGFR, p16 and Ki67 were examined by means of immunohistochemistry. The association between these markers and survival was investigated.

Results: EGFR expression was detected in 14 cases (32.5%), Staining with p16 was positive in 20 cases (46.5%). Mean duration of follow up was 32 months. There was a statistically significant difference between ki67 proliferation indices of patients who survived and those who died (p=0.037). Survival was significantly shorter in EGFR positive patients compared to those negative for EGFR expressions (p=0.037). Mean survival was 30 months in the 20 p16 positive patients and 33.5 months in p16 negative patients (p=0.847).

Conclusion: This study supports that EGFR and Ki67 may be important markers to predict prognosis and survival in patients with head and neck SCC. 

Keywords

head and neck squamous cell carcinoma, EGFR, p16, Ki67, prognosis

Supporting Institution

No financial support was received for this study.

Baş-Boyun Skuamöz Hücreli Karsinomlarında EGFR, P16 ve Ki67 Ekspresyonunun Prognoza Etkisi

Abstract

Amaç: EGFR ve HPV pozitif baş-boyun kanserlerinin, negatif olanlara kıyasla oldukça farklı klinik ve demografik özelliklerinden dolayı HPV ve EGFR ekspresyon durumu bağımsız prognostik faktör olarak kullanılabilir. Bu çalışmanın amacı baş-boyun skuamöz hücreli karsinom vakalarında EGFR, p16 ve ki67 ekspresyonlarının yaşam süresi ile ilişkisini saptamaktır.

Materyal ve Metot: Çalışmaya baş-boyun yerleşimli 47 orta derecede diferansiye skuamöz hücreli karsinom olgusu alındı. Olgulara immünohistokimya ile EGFR, p16 ve ki67 çalışıldı. Bu belirteçlerin yaşam süresiyle ilişkisi değerlendirildi.

Bulgular: Olguların 14’ü (%29,7) EGFR ekspresyonu göstermiş, 33’ünde (%70,3) boyanma görülmemiştir. Olguların 21’inde (%44,6) p16 ile boyanma görülmüş, 26’sında (%55,4) p16 ekspresyonu görülmemiştir. Hastaların ortalama takip süresi 32 aydır. 47 hastanın 15’i hastalık sebebiyle ex olmuştur. Yaşayan ve ex olan hastaların ki67 proliferasyon indeksi arasındaki fark istatistiksel olarak anlamlıdır (p=0,037). EGFR pozitif olan hastaların yaşam süresi, negatif olanlara göre anlamlı olarak daha kısadır (p=0,037). Ortalama sağkalım p16 pozitif 20 hastada 30 ay, p16 negatif hastalarda 33.5 ay idi (p=0,847).

Sonuç: Çalışmamız EGFR ve ki67’nin baş-boyun skuamöz hücreli karsinom hastalarında prognoz ve sağkalımı öngörmek için önemli bir belirteç olabileceğini desteklemektedir.  

Keywords

baş&boyun skuamöz hücreli karsinom, EGFR, p16, ki67, prognoz

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