Evaluation of Incidence and Prognosis of COVID-19 in Patients with Nasal Polyps

Year 2022, Volume: 7 Issue: 2, 175 - 179, 01.06.2022

Necati İlhan , Deniz Demir , Köksal Delibaş , Mehmet Güven , Mahmut Sinan Yılmaz , Ahmet Kara

https://doi.org/10.26453/otjhs.982252

Abstract

Objective: Coronavirus disease 2019 (COVID-19) is a global pandemic infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Type 2 immune response accompanied by type 2 cytokines such as IL-4, IL-5, IL-13, and eosinophilic inflammation, may have a potential protective effect against COVID-19 in chronic rhinosinusitis patients with nasal polyps (CRS + P). In the study, it was aimed to investigation the prevalence and prognosis of COVID-19 in chronic rhinosinusitis patients with nasal polyps (CRS + P).

Materials and Methods: Patients between the ages of 15-65 operated for CRS + P and were compared with the control group in terms of incidence and disease severity.

Results: Covid RT-PCR test was positive in 5.04% of CRS + P patients. This rate was 8.96% in the control group, and the difference between both groups was statistically significant. When the two groups were compared in terms of disease severity, no significant difference was found.

Conclusions: The incidence of COVID-19 was lower in patients with CRS + P. However, further prospective studies are needed to research the relationship between nasal polyp and COVID-19.

Keywords

COVID-19, cytokines, eosinophilic, incidence, nasal polyp

Nazal Polipli Hastalarda COVID-19 İnsidansının ve Prognozunun Değerlendirilmesi

Abstract

Amaç: Koronavirüs hastalığı 2019 (COVID-19), şiddetli akut solunum sendromu koronavirüs-2'nin (SARS-CoV-2) neden olduğu küresel bir pandemik bulaşıcı hastalıktır. IL-4, IL-5, IL-13 gibi tip 2 sitokinlerin ve eozionifililik enflamasyonun eşlik ettiği tip 2 immün yanıt nazal polipli kronik rinosinüzit (KRS+P) hastalarında COVID-19’a karşı potansiyel koruyucu etkisi olabilir. Bu çalışmada nazal polipli kronik rinosinüzit (KRS+P) hastalarında COVİD-19 sıklığı ve prognozu belirlemek amaçlandı.

Materyal ve Metot: KRS+P nedeniyle ameliyat edilen 15-65 yaş arası hastalar, insidans ve hastalık şiddeti açısından kontrol grubu ile karşılaştırıldı.

Bulgular: KRS+P hastalarının %5,04'ünde Covid RT-PCR testi pozitif çıktı. Kontrol grubunda bu oran %8,96 idi ve her iki grup arasındaki fark istatistiksel olarak anlamlıydı. İki grup hastalık şiddeti açısından karşılaştırıldığında anlamlı bir fark bulunmadı.

Sonuç: KRS+P hastalarında COVID-19 insidansı daha düşüktü. Ancak nazal polip ile COVID-19 arasındaki ilişkiyi araştırmak için daha ileri prospektif çalışmalara ihtiyaç vardır.

Keywords

COVID-19, eozinofilik, insidans, nazal polip, sitokinler

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