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Proksimal femur kırıklarında cerrahi zamanlama erken mortaliteyi etkilemez: tek merkez deneyimi

Year 2025, Volume: 18 Issue: 4, 1 - 1

Abstract

Amaç: Bu çalışmada, proksimal femur kırığı olan geriatri hastalarında cerrahi zamanlama ile 30 günlük ve 90 günlük mortalite arasındaki ilişkiyi araştırmak amaçlanmıştır. Ayrıca, literatürde bu tür kırıklar için ideal cerrahi zamanı konusundaki devam eden tartışmayı ele alarak, mortaliteyi potansiyel olarak etkileyebilecek diğer parametreler de değerlendirildi.
Hastalar ve yöntem: 65 yaş ve üzeri femoral boyun kırığı veya intertrokanterik femur kırığı olan 181 hastanın retrospektif analizi yapıldı. Demografik veriler, komorbiditeler, kırık tipi, cerrahi zamanı ve mortalite hakkında veriler toplandı. Hastalar, ameliyat zamanlamasına göre dört gruba ayrıldı: 24 saat içinde, 24-48 saat içinde, 48-72 saat içinde ve 72 saatten sonra. İstatistiksel analizler t-testleri, Mann-Whitney U testleri, Ki-kare testleri ve Bonferroni düzeltmeli post hoc analizlerini içeriyordu. p<0.05 anlamlılık düzeyi kullanıldı.
Bulgular: Toplam 30 günlük ve 90 günlük ölüm oranları sırasıyla %3,86 ve %11,04'tü. Cerrahi zamanı, 30 günlük ve 90 günlük mortaliteyi önemli ölçüde etkilemedi. En yüksek 30 günlük ölüm oranı (%6,7), ilk 24 saat içinde ameliyat edilen hastalarda gözlemlendi; bu durum, muhtemelen aceleci preoperatif hazırlıklardan kaynaklanıyor. En yüksek 90 günlük ölüm oranına sahip grup (%22), muhtemelen komorbiditeler veya antikoagülan kullanımı tarafından etkilenmiş olan 72 saatten sonra ameliyat olan hastalardan oluşuyordu.
Sonuç: Cerrahi zamanlama, proksimal femur kırıklarında mortaliteyi önemli ölçüde etkilemez, ancak en güvenli aralık 24-72 saat gibi görünmektedir. Erken cerrahi, immobilizasyonla ilgili komplikasyonları azaltabilirken, preoperatif optimizasyon için yeterli zaman kritik öneme sahiptir. Hasta hazırlığına odaklanan dengeli bir yaklaşım, katı zamanlama yönergeleri yerine daha iyi sonuçlar sağlar.

References

  • 1. Hagino H, Nakamura T, Sakamoto K, et al. Nationwide survey of hip fractures in Japan. J Orthop Sci. 2004;9(1):1-5. doi:10.1007/s00776-003-0741-8
  • 2. de Jong L, Klem TM, Kuijper TM, Roukema GR. Validation of the Nottingham Hip Fracture Score (NHFS) to predict 30-day mortality in patients with an intracapsular hip fracture. Orthop Traumatol Surg Res. 2019;105(3):485-489. doi:10.1016/j.otsr.2019.02.004
  • 3. Parker M, Johansen A. Hip fracture. BMJ. 2006;333(7557):27-30. doi:10.1136/bmj.333.7557.27
  • 4. Lewis PM, Waddell JP. When is the ideal time to operate on a patient with a fracture of the hip?: a review of the available literature. Bone Joint J. 2016;98(12):1573-1581. doi:10.1302/0301-620X.98B12.BJJ-2016-0362.R2
  • 5. Beaupre LA, Khong H, Smith C, et al. The impact of time to surgery after hip fracture on mortality at 30-and 90-days: Does a single benchmark apply to all? Injury. 2019;50(4):950-955. doi:10.1016/j.injury.2019.03.031
  • 6. Leer Salvesen S, Engesæter LB, Dybvik E, Furnes O, Kristensen TB, Gjertsen JE. Does time from fracture to surgery affect mortality and intraoperative medical complications for hip fracture patients?: an observational study of 73 557 patients reported to the Norwegian Hip Fracture Register. Bone Joint J. 2019;101(9):1129-1137. doi:10.1302/0301-620X.101B9.BJJ-2019-0295.R1
  • 7. Nyholm AM, Gromov K, Palm H, et al. Time to surgery is associated with thirty-day and ninety-day mortality after proximal femoral fracture: a retrospective observational study on prospectively collected data from the Danish fracture database collaborators. J Bone Joint Surg Am. 2015;97(16):1333-1339. doi:10.2106/JBJS.O.00029
  • 8. Schoeneberg C, Aigner R, Pass B, et al. Effect of time-to-surgery on in-house mortality during orthogeriatric treatment following hip fracture: A retrospective analysis of prospectively collected data from 16,236 patients of the AltersTraumaRegister DGU®. Injury. 2021;52(3):554-561. doi:10.1016/j.injury.2020.09.007
  • 9. Leung F, Lau TW, Kwan K, Chow SP, Kung AWC. Does timing of surgery matter in fragility hip fractures? Osteoporos Int. 2010;21(4):529-534. doi:10.1007/s00198-010-1391-2
  • 10. Khan SK, Kalra S, Khanna A, Thiruvengada MM, Parker MJ. Timing of surgery for hip fractures: a systematic review of 52 published studies involving 291,413 patients. Injury. 2009;40(7):692-697. doi:10.1016/j.injury.2009.01.010
  • 11. Greve K, Modig K, Talbäck M, Bartha E, Hedström M. No association between waiting time to surgery and mortality for healthier patients with hip fracture: a nationwide Swedish cohort of 59,675 patients. Acta Orthop. 2020;91(4):396-400. doi:10.1080/17453674.2020.1754645
  • 12. NICE. Hip fracture: management, clinical guideline [CG124]. 2014. Available at: https://www.nice.org.uk/guidance/cg124/chapter/Recommendations#timing-of-surgery. Accessed October 15, 2024.
  • 13. Switzer JA, O’Connor MI. AAOS Management of Hip Fractures in Older Adults Evidence-based Clinical Practice Guideline. J Am Acad Orthop Surg. 2022;30(20):1297-1301. doi:10.5435/JAAOS-D-22-00273
  • 14. Lizaur Utrilla A, Martinez Mendez D, Collados Maestre I, Miralles Muñoz FA, Marco Gomez L, Lopez Prats FA. Early surgery within 2 days for hip fracture is not reliable as healthcare quality indicator. Injury. 2016;47(7):1530-1535. doi:10.1016/j.injury.2016.04.040
  • 15. Welford P, Jones CS, Davies G, et al. The association between surgical fixation of hip fractures within 24 hours and mortality: a systematic review and meta-analysis. Bone Joint J. 2021;103(7):1176-1186. doi:10.1302/0301-620X.103B7.BJJ-2020-2582.R1
  • 16. Rosso F, Dettoni F, Bonasia DE, et al. Prognostic factors for mortality after hip fracture: operation within 48 hours is mandatory. Injury. 2016;47:S91-S97. doi:10.1016/j.injury.2016.07.055
  • 17. Simunovic N, Devereaux PJ, Sprague S, et al. Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis. Cmaj. 2010;182(15):1609-1616. doi:10.1503/cmaj.092220
  • 18. Griffiths R, Alper J, Beckingsale A, et al. Management of proximal femoral fractures 2011. Anaesthesia. 2012;67(1):85-98. doi:10.1111/j.1365-2044.2011.06957.x
  • 19. van Rijckevorsel VA, de Jong L, Verhofstad MHJ, Roukema GR. Influence of time to surgery on clinical outcomes in elderly hip fracture patients: an assessment of surgical postponement due to non-medical reasons. Bone Joint J. 2022;104(12):1369-1378. doi:10.1302/0301-620X.104B12.BJJ-2022-0172.R2
  • 20. De Luca A, Murena L, Zanetti M, De Colle P, Ratti C, Canton G. Should the early surgery threshold be moved to 72 h in over-85 patients with hip fracture? A single-center retrospective evaluation on 941 patients. Arch Orthop Trauma Surg. 2023;143(6):3091-3101. doi:10.1007/s00402-022-04509-y

Surgical timing for proximal femur fractures is not affect early mortality: single center experience

Year 2025, Volume: 18 Issue: 4, 1 - 1

Abstract

Purpose: This study investigates the relationship between surgical timing and 30-day and 90-day mortality in geriatric patients with proximal femur fractures. It also evaluates other parameters potentially affecting mortality, addressing the ongoing debate in the literature about the ideal surgical timing for such fractures.
Patients and methods: A retrospective analysis of 181 patients aged 65 and older with femoral neck or intertrochanteric femur fractures was conducted. Data on demographics, comorbidities, fracture type, surgical timing, and mortality were collected. Patients were categorized into four groups based on surgery timing: within 24 hours, 24-48 hours, 48-72 hours, and after 72 hours. Statistical analyses included t-tests, Mann-Whitney U tests, Chi-square tests, and Bonferroni-corrected post hoc analyses. A significance level of p<0.05 was used.
Results: The overall 30-day and 90-day mortality rates were 3.86% and 11.04%, respectively. Surgical timing did not significantly affect 30-day and 90-day mortality. The highest 30-day mortality rate (6.7%) was observed in patients operated on within the first 24 hours, potentially due to rushed preoperative preparations. The group with the highest 90-day mortality rate (22%) consisted of patients undergoing surgery after 72 hours, likely influenced by comorbidities or anticoagulant use.
Conclusion: Surgical timing does not significantly affect mortality in proximal femur fractures, though the safest interval appears to be 24-72 hours. While early surgery can reduce complications related to immobilization, sufficient time for preoperative optimization is crucial. A balanced approach focusing on patient readiness rather than rigid timing guidelines ensures better outcomes.

References

  • 1. Hagino H, Nakamura T, Sakamoto K, et al. Nationwide survey of hip fractures in Japan. J Orthop Sci. 2004;9(1):1-5. doi:10.1007/s00776-003-0741-8
  • 2. de Jong L, Klem TM, Kuijper TM, Roukema GR. Validation of the Nottingham Hip Fracture Score (NHFS) to predict 30-day mortality in patients with an intracapsular hip fracture. Orthop Traumatol Surg Res. 2019;105(3):485-489. doi:10.1016/j.otsr.2019.02.004
  • 3. Parker M, Johansen A. Hip fracture. BMJ. 2006;333(7557):27-30. doi:10.1136/bmj.333.7557.27
  • 4. Lewis PM, Waddell JP. When is the ideal time to operate on a patient with a fracture of the hip?: a review of the available literature. Bone Joint J. 2016;98(12):1573-1581. doi:10.1302/0301-620X.98B12.BJJ-2016-0362.R2
  • 5. Beaupre LA, Khong H, Smith C, et al. The impact of time to surgery after hip fracture on mortality at 30-and 90-days: Does a single benchmark apply to all? Injury. 2019;50(4):950-955. doi:10.1016/j.injury.2019.03.031
  • 6. Leer Salvesen S, Engesæter LB, Dybvik E, Furnes O, Kristensen TB, Gjertsen JE. Does time from fracture to surgery affect mortality and intraoperative medical complications for hip fracture patients?: an observational study of 73 557 patients reported to the Norwegian Hip Fracture Register. Bone Joint J. 2019;101(9):1129-1137. doi:10.1302/0301-620X.101B9.BJJ-2019-0295.R1
  • 7. Nyholm AM, Gromov K, Palm H, et al. Time to surgery is associated with thirty-day and ninety-day mortality after proximal femoral fracture: a retrospective observational study on prospectively collected data from the Danish fracture database collaborators. J Bone Joint Surg Am. 2015;97(16):1333-1339. doi:10.2106/JBJS.O.00029
  • 8. Schoeneberg C, Aigner R, Pass B, et al. Effect of time-to-surgery on in-house mortality during orthogeriatric treatment following hip fracture: A retrospective analysis of prospectively collected data from 16,236 patients of the AltersTraumaRegister DGU®. Injury. 2021;52(3):554-561. doi:10.1016/j.injury.2020.09.007
  • 9. Leung F, Lau TW, Kwan K, Chow SP, Kung AWC. Does timing of surgery matter in fragility hip fractures? Osteoporos Int. 2010;21(4):529-534. doi:10.1007/s00198-010-1391-2
  • 10. Khan SK, Kalra S, Khanna A, Thiruvengada MM, Parker MJ. Timing of surgery for hip fractures: a systematic review of 52 published studies involving 291,413 patients. Injury. 2009;40(7):692-697. doi:10.1016/j.injury.2009.01.010
  • 11. Greve K, Modig K, Talbäck M, Bartha E, Hedström M. No association between waiting time to surgery and mortality for healthier patients with hip fracture: a nationwide Swedish cohort of 59,675 patients. Acta Orthop. 2020;91(4):396-400. doi:10.1080/17453674.2020.1754645
  • 12. NICE. Hip fracture: management, clinical guideline [CG124]. 2014. Available at: https://www.nice.org.uk/guidance/cg124/chapter/Recommendations#timing-of-surgery. Accessed October 15, 2024.
  • 13. Switzer JA, O’Connor MI. AAOS Management of Hip Fractures in Older Adults Evidence-based Clinical Practice Guideline. J Am Acad Orthop Surg. 2022;30(20):1297-1301. doi:10.5435/JAAOS-D-22-00273
  • 14. Lizaur Utrilla A, Martinez Mendez D, Collados Maestre I, Miralles Muñoz FA, Marco Gomez L, Lopez Prats FA. Early surgery within 2 days for hip fracture is not reliable as healthcare quality indicator. Injury. 2016;47(7):1530-1535. doi:10.1016/j.injury.2016.04.040
  • 15. Welford P, Jones CS, Davies G, et al. The association between surgical fixation of hip fractures within 24 hours and mortality: a systematic review and meta-analysis. Bone Joint J. 2021;103(7):1176-1186. doi:10.1302/0301-620X.103B7.BJJ-2020-2582.R1
  • 16. Rosso F, Dettoni F, Bonasia DE, et al. Prognostic factors for mortality after hip fracture: operation within 48 hours is mandatory. Injury. 2016;47:S91-S97. doi:10.1016/j.injury.2016.07.055
  • 17. Simunovic N, Devereaux PJ, Sprague S, et al. Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis. Cmaj. 2010;182(15):1609-1616. doi:10.1503/cmaj.092220
  • 18. Griffiths R, Alper J, Beckingsale A, et al. Management of proximal femoral fractures 2011. Anaesthesia. 2012;67(1):85-98. doi:10.1111/j.1365-2044.2011.06957.x
  • 19. van Rijckevorsel VA, de Jong L, Verhofstad MHJ, Roukema GR. Influence of time to surgery on clinical outcomes in elderly hip fracture patients: an assessment of surgical postponement due to non-medical reasons. Bone Joint J. 2022;104(12):1369-1378. doi:10.1302/0301-620X.104B12.BJJ-2022-0172.R2
  • 20. De Luca A, Murena L, Zanetti M, De Colle P, Ratti C, Canton G. Should the early surgery threshold be moved to 72 h in over-85 patients with hip fracture? A single-center retrospective evaluation on 941 patients. Arch Orthop Trauma Surg. 2023;143(6):3091-3101. doi:10.1007/s00402-022-04509-y
There are 20 citations in total.

Details

Primary Language English
Subjects Orthopaedics
Journal Section Research Article
Authors

Kemal Şibar 0000-0003-2468-4155

Abdulsamet Emet 0000-0001-5415-218X

Erkan Akgün 0000-0002-7461-3526

Hüseyin Emre Tepedelenlioğlu 0000-0002-3946-8554

Yasin Erdoğan 0000-0001-6862-9671

Turgut Yurdakul 0000-0002-1878-4128

Ahmet Fırat 0000-0001-9182-7270

Early Pub Date February 21, 2025
Publication Date
Submission Date November 19, 2024
Acceptance Date February 11, 2025
Published in Issue Year 2025 Volume: 18 Issue: 4

Cite

AMA Şibar K, Emet A, Akgün E, Tepedelenlioğlu HE, Erdoğan Y, Yurdakul T, Fırat A. Surgical timing for proximal femur fractures is not affect early mortality: single center experience. Pam Med J. February 2025;18(4):1-1.

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