Atipik Prezentasyonlu İki Çocukluk Çağı Brusellozis Olgusu

Year 2010, Volume: 8 Issue: 2, 39 - 43, 01.09.2010

Tolga Altuğ Şen , Tevfik Demir Reşit Köken Afşin Ahmet Kundak Faruk Alpay

Abstract

Giriş: Brusellozis ülkemizde hala sık görülmekte, zaman zaman seyrek görülen klinikbulgularla prezente olabilmektedir.Olgu 1: On yaşında erkek hasta halsizlik, kilo kaybı, dişeti kanaması nedeniyle kliniğimize başvurdu. Fizik muayenesinde servikal bölgede lenfadenopati, hepatosplenomegalitespit edilen olgunun tam kan sayımında pansitopenisinin olduğu gözlendi. Kemik iliğiaspirasyonu incelemesinde, kemik iliği elemanlarının hiposellüler olduğu görüldü. Brusella aglütinasyon titresi 1:1280 olan olgunun kan kültüründe Brusella mellitensis üredi. Pansitopeninin brusellaya yönelik antibiyotik tedavisinden sonra düzeldiği gözlendi.Olgu 2: Dokuz yaşındaki kız olgu acil servisimize birkaç gündür süren çarpıntı nedeniyle başvurdu. Kalp hızı dakikada 136 sayılan olgunun elektrokardiyografisi sinüzal taşikardiyle uyumlu bulundu. Ekokardiyografik incelemesi tamamen normal olan olgununöyküsünde son 1 aydır kilo kaybı ve kolay yorulma olması üzerine bakılan brusella aglütinasyon titresi 1:1280 bulundu. Kan kültüründe mikroorganizma üremeyen olgununbrusella için başlanılan antiyoterapiye iyi yanıt verdiği, 1 hafta sonra kalp hızının normale döndüğü gözlendi. Tek başına taşikardinin bulunması brusella hastalığı için dahaönce bildirilmemiş erken bir bulgu olarak dikkatimizi çekmiştir.Tartışma: Brusella pansitopeninin nadir nedenlerinden biridir; bu nedenle pansitopeninin ayırıcı tanısında akla getirilmelidir. Brusella kardiyovasküler sistemi tutabilen birhastalık olarak bilinse de daha önce tek bulgunun ateşe bağlı olmayan taşikardi olduğu ve tedaviyle taşikardinin gerilediği bir olgu bildirilmemiş olması olgumuzu ilginç kılmaktadır

Keywords

Brusellozis, pansitopeni, çocuk, taşikardi

Two Unusual Presentations of Childhood Brucella Cases

Abstract

Introduction: Brucellozis is still a common infectious disease in our country and sometimes it may be presented with uncommon clinical manifestations.Case 1: A ten years old male was presented to our clinic with complaints of malaise,weight loss, petechia, and bleeding of gums. On physical examination cervical lymphadenopathy and hepatosplenomegaly had been detected and in complete bloodcount pancytopenia was found.admitted to our clinic. In bone marrow aspiration hypocellular bone marrow was seen. His Brucella agglutination test was positive at1:1280 titer and the blood culture was positive for Brucella mellitensis. The pancytopenia was resolved after the antibiotherapy. Case 2: A nine-year-old female was referred to our clinic with tachycardia, who hadthe cardiac rate of 136/min. The electrocardiography showed sinusal tachycardia andechocardiography was normal, no endocarditis or pericarditis was present. She hadcomplaints of fatigue and lassitude for the last month. Her brucella agglutination testwas positive at 1:1280 titer and blood culture was negative. After antibiotherapy hersymptoms regressed, cardiac rate decreased to 80-100/min. Isolated tachycardia maybe the early manifestaion of brucellosis in children which has not been reported previously. Conclusion: Brucellosis is a rare cause of pancytopenia, it should be considered in differential diagnosis with pancytopenia of children. Brucellosis was known to be involved cardiovascular system, but tachycardia which was not due to fever as theonly sign of disease has not been reported previously made our case very interesting

Keywords

Brucellosis, pancytopenia, childhood, tachycardia

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