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Yenidoğan Sarılıklarında Tedavi Yaklaşımı

Year 2006, Volume: 4 Issue: 1, 118 - 123, 01.04.2006

Merih Çetinkaya , Nilgün Köksal Hilal Özkan

Abstract

Sarılık, yenidoğan döneminde en sık görülen problemlerden birisidir. Yenidoğan bebeklerin yarısından fazlasında yaşamın ilk günlerinde sarılık gelişebilir 1 . Erişkinlerde >2mg/dl, yenidoğanlarda >6mg/dl olduğunda, sarılık gözle görülebilir hale gelir. Sarılıklı bir bebek ile karşılaşıldığında fizyolojik mi, incelemeye gerek var mı, hangi tetkikler istenmeli, tehlike var mı, potansiyel tehlike nasıl saptanabilir, tehlike varsa nasıl tedavi edilmelidir gibi sorulara cevap aranmalıdır 1 .

References

  • 1. Fetus and Newborn Committee, Canadian Paediatric Society (CPS). Approach to the management of hyperbilirubinemia in term newborn infants. Paediatrics & Child Health 1999; 4:161-4.
  • 2. Alpay F. Sar›l›k. Yurdakök M, Erdem G (eds). Neonatoloji. 2.Bask›. Ankara,Alp Ofset I. 2004.p.559-78.
  • 3. MacMahon JR, Stevenson DK, Oski FA. Physiologic jaundice. In: Taeusch HW, Ballard RA (eds). Avery's Disease of the Newborn. 7nd edition. Philadelphia: WB Saunders, Publishers; 2000.p.51-66.
  • 4. Watchko JF. Indirect hyperbilirubinemia in the neonate. In: Maisels MJ, Watchko (eds). Neonatal Jaundice Monographs in Clinical Pediatrics. Singapore: Harwood Academic Publishers; 2000.p.51-66.
  • 5. Oski FA. The erythrocyte and its disorders. In: Nathan DG, Oski FA (eds). Hematology of Infancy and Chilhood. Philadelphia: WB Saunders; 1993.p.18-43.
  • 6. Vales T. Neonatal jaundice in glucose-6-phosphate dehydrogenase deficiency. In: Maisels MJ, Watchko (eds). Neonatal Jaundice Monographs in Clinical Pediatrics. Singapore: Harwood Academic Publishers; 2000.p.62-72.
  • 7. Kaplan M, Hammermann C. Glucose-6-phosphate dehydrogenase deficiency: a potential source of severe neonatal hyperbilirubinaemia and kernicterus. Semin Neonatol 2002; 7:121-8.
  • 8. MacMahon JR, Stevenson DK, Oski FA. Unconjugated hyperbilirubinemias. In: Taeusch HW, Ballard RA (eds). Avery's Disease of the Newborn. 7nd edition. Philadelphia: WB Saunders, Publishers; 1998.p.1014-20.
  • 9. Vogl TP. Phototherapy of neonatal hyperbilirubinemia: bilirubin in unexposed areas of the skin. J Pediatr 1974; 85:707-10.
  • 10. Rubaltelli FF, Carli M. The effect of light on cutaneous bilirubin. Biol Neonate 1971; 18:457-62.
  • 11. Sisson TR. Phototherapy of hyperbilirubinemia in the newborn. Fortschr Med 1973; 91:563-6.
  • 12. Bonta BW, Warshaw JB. Importance of radiant flux in the treatment of hyperbilirubinemia: failure of overhead phototherapy units in intensive care units. Pediatrics 1976; 57:502-5.
  • 13. Warshaw JB, Gagliardi J, Patel A. A comparison of fluorescent and nonfluorescent light sources for phototherapy. Pediatrics 1980; 65:795-8.
  • 14. Kaplan M, Muraca M, Hammerman C, Vilei MT, Rubaltelli FF. Unconjugated and conjugated bilirubin pigments during perinatal development. Effect of phototherapy on serum conjugated bilirubin in hyperbilirubinemic neonates. Biol Neonate 1998; 73:155-60.
  • 15. Ennever JF. Blue light, green light, white light, more light: treatment of neonatal jaundice. Clin Perinatol 1990; 1:467-81.
  • 16. Myara A, Sender A, Valette V, Rostoker C, Paumier D, Capoulade C, Loridon F, Bouillie J, Milliez J, Brossard Y, Trivin F. Early changes in cutaneous bilirubin and serum bilirubin isomers during intensive phototherapy of jaundiced neonates with blue green light. Biol Neonate 1997;7:75-82.
  • 17. Costarino AT Jr, Ennever JF, Baumgart S, Speck WT, Polin RA. Effect of spectral distribution on isomerization of bilirubin in vivo. J Pediatr 1985; 107:125-8.
  • 18. Romagnoli C, Zecca E, Papacci P, Vento G, Girlando P, Latella C. Which phototherapy system is most effective in lowering serum bilirubin in very preterm infants? Fetal Diagn Ther 2006; 2:204-9.
  • 19. van Kaam AH, van Beek RH, Vergunst-van Keulen JG, van der Heijden J, Lutz-Dettinger N, Hop W, Sauer PJ. Fibre optic versus conventional phototherapy for hyperbilirubinaemia in preterm infants. Eur J Pediatr 1998; 157:132-7.
  • 20. Tan KL. Comparison of the efficacy of fiberoptic and conventional phototherapy for neonatal hyperbilirubinemia. Pediatr 1994; 125:607-12.
  • 21. Tan KL. Efficacy of bidirectional fiber-optic phototherapy for neonatalhyperbilirubinemia. Pediatrics 1997; 99:E13.
  • 22. Seidman DS, Moise J, Ergaz Z, Laor A, Vreman HJ, Stevenson DK, Gale R. A Prospective Randomized Controlled Study of Phototherapy Using Blue and Blue-Green Light-Emitting Devices, and Conventional Halogen-Quartz Phototherapy. J Perinatology 2003; 23:123-7.
  • 23. American Academy of Pediatrics clinical guideline on the management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004; 114:297-316.
  • 24. Meropol SB, Luberti AA, De Jong AR, Weiss JC.Home phototherapy: use and attitudes among community pediatricians. Pediatrics 1993; 91:97-100.
  • 25. Dyk J. Home phototherapy: reliable equipment, family education assure quality treatment. Contin Care 1990;9:44-6.
  • 26. Fuller J. Home phototherapy. Caring 1990; 9:8-11.
  • 27. Eggert LD, Pollary RA, Folland DS, Jung AL. Home phototherapy treatment of neonatal jaundice. Pediatrics 1985; 7:579-84.
  • 28. Horn AR, Kirsten GF, Kroon SM, Henning PA, Moller G, Pieper C, Adhikari M, Cooper P, Hoek B, Delport S, Nazo M, Mawela B. Phototherapy and exchange transfusion for neonatal hyperbilirubinaemia: Neonatal academic hospitals' consensus guidelines for South African hospitals and primary care facilities. S Afr Med J 2006; 96:819-24.
  • 29. Watchko JF. Exchange transfusion in the management of neonatal hyperbilirubinemia. In: Maisels MJ, Watchko (eds). Neonatal Jaundice Monographs in Clinical Pediatrics. Singapore: Harwood Academic Publishers; 2000.p.169-76.
  • 30. Sanpavat S. Exchange transfusion and its morbidity in ten-year period at King Chulalongkorn Hospital. J Med Assoc Thai 2005; 88:588-92.
  • 31. Abu-Ekteish F, Daoud A, Rimawi H, Kakish K, Abu-Heija A. Neonatal exchange transfusion: a Jordanian experience. Ann Trop Paediatr 2000; 20:57-60.
  • 32. Weisz B, Belson A, Milbauer B, Reif S. Complications of exchange transfusion in term and preterm newborns. Harefuah 1996; 130:170-223.
  • 33. Patra K, Storfer-Isser A, Siner B, Moore J, Hack M. Adverse events associated with neonatal exchange transfusion in the 1990. J Pediatr 2004; 144:626-31.
  • 34. Alpay F, Sarici SU, Okutan V, Erdem G, Ozcan O, Gokcay E. High-dose intravenous immunoglobulin therapy in neonatal immune haemolytic jaundice. Acta Paediatr 1999; 88:216-9.
  • 35. Miqdad AM, Abdelbasit OB, Shaheed MM, Seidahmed MZ, Abomelha AM, Arcala OP.Intravenous immunoglobulin G (IVIG) therapy for significant hyperbilirubinemia in ABO hemolytic disease of the newborn. J Matern Fetal Neonatal Med 2004; 16:163-6.
  • 36. Rubo J, Albrecht K, Lasch P, Laufkotter E, Leititis J, Marsan D, Niemeyer B, Roesler J, Roll C, Roth B, et al. High-dose intravenous immune globulin therapy for hyperbilirubinemia caused by Rh hemolytic disease. J Pediatr 1992; 121:93-7.
  • 37. Dennery PA. Pharmacological interventions for the treatment of neonatal jaundice. Semin Neonatol 2002; 7:111-9.
  • 38. Dennery PA. Metalloporphyrins for the treatment of neonatal jaundice. Curr Opin Pediatr 2005; 17:167-9.
  • 39. Reddy P, Najundaswamy S, Mehta R, Petrova A, Hegyi T. Tin-mesoporphyrin in the treatment of severe hyperbilirubinemia in a very-low-birth-weight infant. J Perinatol 2003; 23:507-8.
  • 40. Martinez JC, Garcia HO, Otheguy LE, Drummond GS, Kappas A. Treatment of hyperbilirubinemia pharmacologic approach SnMP(tin-mesoporphyrin). J Perinatol 2001; 21:101-7.
  • 41. Lindenbaum A, Hernandorena X, Vial M, Benattar C, Janaud JC, Dehan M, Foliot A, Leluc R, Gabilan JC. Clofibrate for the treatment of hyperbilirubinemia in neonates born at term: a double blind controlled study (author's transl). Arch Fr Pediatr 1981; 38:867-73.
  • 42. Mohammadzadeh A, Farhat ASh, Iranpour R. Effect of clofibrate in jaundiced term newborns. Indian J Pediatr 2005; 72:123-6.
  • 43. Lanone S, Bloc S, Foresti R, Almolki A, Taille C, Callebert J, Conti M, Goven D, Aubier M, Dureuil B, El-Benna J, Motterlini R, Boczkowski J. Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats. FASEB J 2005; 19:1890-2.
  • 44. Wang WW, Smith DL, Zucker SD. Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats. Hepatology 2004; 40:424-33.
  • 45. American Academy of Pediatrics. Neonatal Jaundice and Kernicterus. Pediatrics 2001; 108:763-5.
  • 46. Johnson LH, Bhutani VK, Brown AK. System-based approach to management of neonatal jaundice and prevention of kernicterus. J Pediatr 2002; 140:396-403.
  • 47. AAP Subcommittee on Neonatal Hyperbilirubinemia. Neonatal jaundice and kernicterus. Pediatrics 2001; 108:763-5.

Year 2006, Volume: 4 Issue: 1, 118 - 123, 01.04.2006

Merih Çetinkaya , Nilgün Köksal Hilal Özkan

Abstract

References

  • 1. Fetus and Newborn Committee, Canadian Paediatric Society (CPS). Approach to the management of hyperbilirubinemia in term newborn infants. Paediatrics & Child Health 1999; 4:161-4.
  • 2. Alpay F. Sar›l›k. Yurdakök M, Erdem G (eds). Neonatoloji. 2.Bask›. Ankara,Alp Ofset I. 2004.p.559-78.
  • 3. MacMahon JR, Stevenson DK, Oski FA. Physiologic jaundice. In: Taeusch HW, Ballard RA (eds). Avery's Disease of the Newborn. 7nd edition. Philadelphia: WB Saunders, Publishers; 2000.p.51-66.
  • 4. Watchko JF. Indirect hyperbilirubinemia in the neonate. In: Maisels MJ, Watchko (eds). Neonatal Jaundice Monographs in Clinical Pediatrics. Singapore: Harwood Academic Publishers; 2000.p.51-66.
  • 5. Oski FA. The erythrocyte and its disorders. In: Nathan DG, Oski FA (eds). Hematology of Infancy and Chilhood. Philadelphia: WB Saunders; 1993.p.18-43.
  • 6. Vales T. Neonatal jaundice in glucose-6-phosphate dehydrogenase deficiency. In: Maisels MJ, Watchko (eds). Neonatal Jaundice Monographs in Clinical Pediatrics. Singapore: Harwood Academic Publishers; 2000.p.62-72.
  • 7. Kaplan M, Hammermann C. Glucose-6-phosphate dehydrogenase deficiency: a potential source of severe neonatal hyperbilirubinaemia and kernicterus. Semin Neonatol 2002; 7:121-8.
  • 8. MacMahon JR, Stevenson DK, Oski FA. Unconjugated hyperbilirubinemias. In: Taeusch HW, Ballard RA (eds). Avery's Disease of the Newborn. 7nd edition. Philadelphia: WB Saunders, Publishers; 1998.p.1014-20.
  • 9. Vogl TP. Phototherapy of neonatal hyperbilirubinemia: bilirubin in unexposed areas of the skin. J Pediatr 1974; 85:707-10.
  • 10. Rubaltelli FF, Carli M. The effect of light on cutaneous bilirubin. Biol Neonate 1971; 18:457-62.
  • 11. Sisson TR. Phototherapy of hyperbilirubinemia in the newborn. Fortschr Med 1973; 91:563-6.
  • 12. Bonta BW, Warshaw JB. Importance of radiant flux in the treatment of hyperbilirubinemia: failure of overhead phototherapy units in intensive care units. Pediatrics 1976; 57:502-5.
  • 13. Warshaw JB, Gagliardi J, Patel A. A comparison of fluorescent and nonfluorescent light sources for phototherapy. Pediatrics 1980; 65:795-8.
  • 14. Kaplan M, Muraca M, Hammerman C, Vilei MT, Rubaltelli FF. Unconjugated and conjugated bilirubin pigments during perinatal development. Effect of phototherapy on serum conjugated bilirubin in hyperbilirubinemic neonates. Biol Neonate 1998; 73:155-60.
  • 15. Ennever JF. Blue light, green light, white light, more light: treatment of neonatal jaundice. Clin Perinatol 1990; 1:467-81.
  • 16. Myara A, Sender A, Valette V, Rostoker C, Paumier D, Capoulade C, Loridon F, Bouillie J, Milliez J, Brossard Y, Trivin F. Early changes in cutaneous bilirubin and serum bilirubin isomers during intensive phototherapy of jaundiced neonates with blue green light. Biol Neonate 1997;7:75-82.
  • 17. Costarino AT Jr, Ennever JF, Baumgart S, Speck WT, Polin RA. Effect of spectral distribution on isomerization of bilirubin in vivo. J Pediatr 1985; 107:125-8.
  • 18. Romagnoli C, Zecca E, Papacci P, Vento G, Girlando P, Latella C. Which phototherapy system is most effective in lowering serum bilirubin in very preterm infants? Fetal Diagn Ther 2006; 2:204-9.
  • 19. van Kaam AH, van Beek RH, Vergunst-van Keulen JG, van der Heijden J, Lutz-Dettinger N, Hop W, Sauer PJ. Fibre optic versus conventional phototherapy for hyperbilirubinaemia in preterm infants. Eur J Pediatr 1998; 157:132-7.
  • 20. Tan KL. Comparison of the efficacy of fiberoptic and conventional phototherapy for neonatal hyperbilirubinemia. Pediatr 1994; 125:607-12.
  • 21. Tan KL. Efficacy of bidirectional fiber-optic phototherapy for neonatalhyperbilirubinemia. Pediatrics 1997; 99:E13.
  • 22. Seidman DS, Moise J, Ergaz Z, Laor A, Vreman HJ, Stevenson DK, Gale R. A Prospective Randomized Controlled Study of Phototherapy Using Blue and Blue-Green Light-Emitting Devices, and Conventional Halogen-Quartz Phototherapy. J Perinatology 2003; 23:123-7.
  • 23. American Academy of Pediatrics clinical guideline on the management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004; 114:297-316.
  • 24. Meropol SB, Luberti AA, De Jong AR, Weiss JC.Home phototherapy: use and attitudes among community pediatricians. Pediatrics 1993; 91:97-100.
  • 25. Dyk J. Home phototherapy: reliable equipment, family education assure quality treatment. Contin Care 1990;9:44-6.
  • 26. Fuller J. Home phototherapy. Caring 1990; 9:8-11.
  • 27. Eggert LD, Pollary RA, Folland DS, Jung AL. Home phototherapy treatment of neonatal jaundice. Pediatrics 1985; 7:579-84.
  • 28. Horn AR, Kirsten GF, Kroon SM, Henning PA, Moller G, Pieper C, Adhikari M, Cooper P, Hoek B, Delport S, Nazo M, Mawela B. Phototherapy and exchange transfusion for neonatal hyperbilirubinaemia: Neonatal academic hospitals' consensus guidelines for South African hospitals and primary care facilities. S Afr Med J 2006; 96:819-24.
  • 29. Watchko JF. Exchange transfusion in the management of neonatal hyperbilirubinemia. In: Maisels MJ, Watchko (eds). Neonatal Jaundice Monographs in Clinical Pediatrics. Singapore: Harwood Academic Publishers; 2000.p.169-76.
  • 30. Sanpavat S. Exchange transfusion and its morbidity in ten-year period at King Chulalongkorn Hospital. J Med Assoc Thai 2005; 88:588-92.
  • 31. Abu-Ekteish F, Daoud A, Rimawi H, Kakish K, Abu-Heija A. Neonatal exchange transfusion: a Jordanian experience. Ann Trop Paediatr 2000; 20:57-60.
  • 32. Weisz B, Belson A, Milbauer B, Reif S. Complications of exchange transfusion in term and preterm newborns. Harefuah 1996; 130:170-223.
  • 33. Patra K, Storfer-Isser A, Siner B, Moore J, Hack M. Adverse events associated with neonatal exchange transfusion in the 1990. J Pediatr 2004; 144:626-31.
  • 34. Alpay F, Sarici SU, Okutan V, Erdem G, Ozcan O, Gokcay E. High-dose intravenous immunoglobulin therapy in neonatal immune haemolytic jaundice. Acta Paediatr 1999; 88:216-9.
  • 35. Miqdad AM, Abdelbasit OB, Shaheed MM, Seidahmed MZ, Abomelha AM, Arcala OP.Intravenous immunoglobulin G (IVIG) therapy for significant hyperbilirubinemia in ABO hemolytic disease of the newborn. J Matern Fetal Neonatal Med 2004; 16:163-6.
  • 36. Rubo J, Albrecht K, Lasch P, Laufkotter E, Leititis J, Marsan D, Niemeyer B, Roesler J, Roll C, Roth B, et al. High-dose intravenous immune globulin therapy for hyperbilirubinemia caused by Rh hemolytic disease. J Pediatr 1992; 121:93-7.
  • 37. Dennery PA. Pharmacological interventions for the treatment of neonatal jaundice. Semin Neonatol 2002; 7:111-9.
  • 38. Dennery PA. Metalloporphyrins for the treatment of neonatal jaundice. Curr Opin Pediatr 2005; 17:167-9.
  • 39. Reddy P, Najundaswamy S, Mehta R, Petrova A, Hegyi T. Tin-mesoporphyrin in the treatment of severe hyperbilirubinemia in a very-low-birth-weight infant. J Perinatol 2003; 23:507-8.
  • 40. Martinez JC, Garcia HO, Otheguy LE, Drummond GS, Kappas A. Treatment of hyperbilirubinemia pharmacologic approach SnMP(tin-mesoporphyrin). J Perinatol 2001; 21:101-7.
  • 41. Lindenbaum A, Hernandorena X, Vial M, Benattar C, Janaud JC, Dehan M, Foliot A, Leluc R, Gabilan JC. Clofibrate for the treatment of hyperbilirubinemia in neonates born at term: a double blind controlled study (author's transl). Arch Fr Pediatr 1981; 38:867-73.
  • 42. Mohammadzadeh A, Farhat ASh, Iranpour R. Effect of clofibrate in jaundiced term newborns. Indian J Pediatr 2005; 72:123-6.
  • 43. Lanone S, Bloc S, Foresti R, Almolki A, Taille C, Callebert J, Conti M, Goven D, Aubier M, Dureuil B, El-Benna J, Motterlini R, Boczkowski J. Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats. FASEB J 2005; 19:1890-2.
  • 44. Wang WW, Smith DL, Zucker SD. Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats. Hepatology 2004; 40:424-33.
  • 45. American Academy of Pediatrics. Neonatal Jaundice and Kernicterus. Pediatrics 2001; 108:763-5.
  • 46. Johnson LH, Bhutani VK, Brown AK. System-based approach to management of neonatal jaundice and prevention of kernicterus. J Pediatr 2002; 140:396-403.
  • 47. AAP Subcommittee on Neonatal Hyperbilirubinemia. Neonatal jaundice and kernicterus. Pediatrics 2001; 108:763-5.
There are 47 citations in total.

Details

Primary Language Turkish
Journal Section Collection
Authors

Merih Çetinkaya

Nilgün Köksal This is me

Hilal Özkan This is me

Publication Date April 1, 2006
Published in Issue Year 2006 Volume: 4 Issue: 1

Cite

APA Çetinkaya, M., Köksal, N., & Özkan, H. (2006). Yenidoğan Sarılıklarında Tedavi Yaklaşımı. Güncel Pediatri, 4(1), 118-123.
AMA Çetinkaya M, Köksal N, Özkan H. Yenidoğan Sarılıklarında Tedavi Yaklaşımı. Güncel Pediatri. April 2006;4(1):118-123.
Chicago Çetinkaya, Merih, Nilgün Köksal, and Hilal Özkan. “Yenidoğan Sarılıklarında Tedavi Yaklaşımı”. Güncel Pediatri 4, no. 1 (April 2006): 118-23.
EndNote Çetinkaya M, Köksal N, Özkan H (April 1, 2006) Yenidoğan Sarılıklarında Tedavi Yaklaşımı. Güncel Pediatri 4 1 118–123.
IEEE M. Çetinkaya, N. Köksal, and H. Özkan, “Yenidoğan Sarılıklarında Tedavi Yaklaşımı”, Güncel Pediatri, vol. 4, no. 1, pp. 118–123, 2006.
ISNAD Çetinkaya, Merih et al. “Yenidoğan Sarılıklarında Tedavi Yaklaşımı”. Güncel Pediatri 4/1 (April 2006), 118-123.
JAMA Çetinkaya M, Köksal N, Özkan H. Yenidoğan Sarılıklarında Tedavi Yaklaşımı. Güncel Pediatri. 2006;4:118–123.
MLA Çetinkaya, Merih et al. “Yenidoğan Sarılıklarında Tedavi Yaklaşımı”. Güncel Pediatri, vol. 4, no. 1, 2006, pp. 118-23.
Vancouver Çetinkaya M, Köksal N, Özkan H. Yenidoğan Sarılıklarında Tedavi Yaklaşımı. Güncel Pediatri. 2006;4(1):118-23.