COVID-19 Pozitif Semptomatik Çocukların D Vitamini Düzeyleri

Year 2021, Volume: 19 Issue: 1, 9 - 14, 09.04.2021

Elif Söbü , Ayşe Karaaslan Ceren Çetin Yasemin Akın

Abstract

Giriş: D vitamini bir vitamin olarak bilinmesine rağmen aynı zamanda bir prohormon görevi görür ve birçok işlevi vardır. Çalışmamızda COVID-19 enfeksiyonu tanısı ile izlenen pediyatrik hastalarda D vitamini düzeylerinin değerlendirilmesi amaçlandı.

Gereç ve Yöntem: Çalışmamız Mart-Nisan 2020 tarihlerinde İstanbul’da bir 3. basamak eğitim ve araştırma hastanesinde gerçekleştirildi. Semptomatik COVID-19 enfeksiyonu tanısı alan çocuklar çalışmaya dahil edildi. Demografik, klinik ve laboratuvar bulgular retrospektif olarak hasta dosyalarından kaydedildi.
Tüm hastaların D vitamini seviyeleri değerlendirildi. Kontrol grubu aynı mevsimde pediyatri polikliniğine rutin kontrol için başvuran sağlıklı çocuklardan oluşturuldu. Otuz COVID (+) ve 82 sağlıklı çocuk 25-OH vitamin D düzeyleri açısından karşılaştırıldı.

Bulgular: COVID-19 pozitif hastaların ortanca yaşı 11,8 (1,8-17,6), kontrol grubunun ortanca yaşı 12,7 (1-16,4) idi. Enfekte grupta 15 (%50) kız, 15 (%50) erkek, kontrol grubunda 39 (%47,5) kız, 43 (%52,5) erkek vardı. Yaş ve cinsiyet gruplar arasında farklılık göstermiyordu. COVID-19 pozitif grupta medyan D vitamini seviyesi 8,9 ng/ml (3-42 ng / ml), kontrol grubunda 18,5 ng/ml (9- 40,7 ng/ml) idi. COVID19 (+) grupta kontrol grubuna göre istatistiksel olarak anlamlı daha düşük D vitamini düzeyleri saptandı (p<0.001). COVID-19 pozitif grupta 19 hastaya BT yapıldı ve 19 hastanın 12’sinde (%63) viral pnömoni tespit edildi. Pnömoni (+) grupta 17,4 yaşında kız hasta ve 13,1 yaşında erkek hastada yaşa göre düşük fosfor seviyeleri (2,2 ve 2,4 mg/dl) bulundu. Her ikisinin de yüksek akımlı oksijen tedavisine ihtiyacı oldu, diğer vakaların hiçbiri oksijen tedavisine ihtiyaç duymadı.

Sonuç: Çalışmamız, Türkiye’de çocuklarda COVID-19 enfeksiyonu ile yatırılarak tedavi edilen olguların D vitamini düzeylerinin araştırıldığı ilk çalışmadır. Yatırılarak tedavi edilen COVID-19 (+) çocuklarda daha düşük D vitamini değerleri tespit ettik.

Keywords

COVID-19,, vitamin D,, hypophosphatemia

Vitamin D Levels of COVID-19 Positive Sypmtomatic Pediatric Cases

Abstract

Introduction:Vitamin D is known as a vitamin but also it acts as a prohormone and has many functions. The aim of this study is to investigate the vitamin D levels
in pediatric patients with COVID-19.

Materials and Methods: A retrospective study was performed in a tertiary education and research hospital in Istanbul, Turkey during the period of March to April 2020. Children diagnosed with symptomatic COVID-19 infection were included in the study. Demographic, clinical and laboratory findings were recorded from patient charts retrospectively. All patients investigated for vitamin D levels. Control group consists of healthy children admitted to pediatric outpatient units for routine check-up in the same season.Thirty children with COVID-19 and 82 healthy children included in this study were compared due to 25-OH vitamin D levels.

Results: The median age of COVID-19 positive patients was 11.8 (1.8-17.6) years and the median age of control group was 12.7 (1-16.4) years old. There were 15
(50%) females and 15 (50%) males in infected group and there were 39 (47.5%) females and 43 (52.5%) males control group. Age and gender did not differ among
the groups. Median vitamin D level in COVID-19 positive group was 8.9 ng/ml (3-42 ng/ml) and 18.5 ng/ml (9-40.7 ng/ml) in control group. We detected significantly
lower vitamin D values in COVID19(+) group when compared with control group (p<0.001). CT was performed 19 patients in COVID-19 positive group and viral
pneumonia was detected in 12(63%) of 19. pneumonia (+) group a 17.4-years-old female patient and a 13.1-years-old male patient had low phosphorus levels by age
(2.2 and 2.4 mg/dl). Both of them needed high flow oxygen therapy. None of the other cases needed oxygen therapy.

Conclusions: This is the first study to date has measured vitamin D levels in children with COVID-19 in Turkey. We detected significantly lower vitamin D
values in COVID-19(+) hospitalized children.

Keywords

COVID-19,, vitamin D,, hypophosphatemia

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