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Evaluatıon Of Clınıcal And Laboratory Fındıngs Of Children And Adolescent Patıents Wıth Hashımoto Thyroıdıtıs

Year 2019, Volume: 7 Issue: Ek - IRUPEC 2019 Kongresi Tam Metin Bildirileri, 427 - 431, 10.12.2019

Abstract

Objective:
The purpose of this study was to evaluate the clinical and laboratory findings of 73 children and adolescents followed-up with a diagnosis of Hashimoto’s thyroiditis.
Methods: Seventy-three patients aged between 4 and 18 years followed-up with a diagnosis of Hashimoto’s thyroiditis at the pediatric endocrinology clinic between 2016 and 2019 were included in the study. All patients’ thyroid function tests, thyroid antibodies, physical examination findings and thyroid ultrasonography results at diagnosis and follow-up were evaluated.

Results:
Fifty-seven (78.1%) patients were girls and 12 (21.9%) were boys, with a female/male ratio of 3.5/1. Goiter was detected at time of diagnosis in 25 cases (34.2%), but not in 48 (65/8%). At time of diagnosis, hyperthyroidism was present in 13 cases (17.8%), hypothyroidism in 16 (22%), subclinical hypothyroidism in 9 (12.3%), euthyroidism in 33 (45.2%), and subclinical hyperthyroidism in 2 (2.7%). The most common symptoms at time of presentation were swelling in the neck, sweating, fatigue, and lack of appetite. Heterogeneity and a hypoechoic appearance were observed in 77% of cases and nodules in 11% at thyroid ultrasonographic examination, while no pathology was determined in 12%.

Conclusions:
Children and adolescents with Hashimoto’s thyroiditis may exhibit different and clinical findings. Thyroid ultrasonography occupies an important place in the diagnosis and follow-up of the disease.
Key words: Hashimoto’s thyroiditis, child, adolescent

References

  • References 1. Becker KL. Principles and Practices of Endocrinology and Metabolism. Second ed. Philadelphia: J.B. Lippincott Co. 1995; 414-417. 2. Gopalakrishnan S, Marwaha RK. Juvenile Autoimmune Thyroiditis. J Pediatr Endocrinol and Metab. 2007, Cilt 20, s. 961-70. 3. Lehmann, H. W, Lutterbüse, N, Plentz, A, et al. Association of Parvovirus B19 Infection and Hashimoto’s Thyroiditis in Children. Viral Immunology, 2008;21:379-383. doi:10. 1089/vim.2008. 0001 4. Fisher DA. Thyroid disorders in childhood and adolecence. In: Sperling MA, editör. Pediatric Endocrinology. 3rd ed. Philadelphia: Saunders Elsevier, 2008; 227-53. 5. Demirbilek H, Kandemir N, Gonc EN, Ozon A, Alikasifoglu A, Yordam N. Hashimoto's thyroiditis in children and adolescents: a retrospective study on clinical, epidemiological and laboratory properties of the disease. J Pediatr Endocrinol Metab. 2007;20(11):1199-205. 6. Jeong SH, Hong HS, Lee JY. The association between thyroid echogenicity and thyroid function in pediatric and adolescent Hashimoto's thyroiditis. Medicine (Baltimore). 2019 Apr;98(14):e15055. doi: 10. 1097/MD. 0000000000015055. 7. Kabelitz M, Liesenkötter KP, Stach B, et al. The prevalence of anti-thyroid peroxidase antibodies and autoimmune thyroiditis in children and adolescents in an iodine replete area. Eur J Endocrinol 2003;148:301–307 8. Gönç N, Kandemir N. Guatr. 1. Baskı. İstanbul: Çocuk Endokrinolojisi 2013.p.345-54 9. Setian N. Hypothyroidism in children: diagnosis and treatment. J Pediatr 2007;83(5):209-16. 10. Yeşilkaya E, Belen B, Bideci A, Çamurdan O, Boyraz M, Cinaz P. Kronik otoimmün tiroiditli çocuk ve ergenlerin klinik özellikleri. Gülhane Tıp Dergisi. 2008; 50: 147-50. 11. Özer S, Sönmezgöz E, Yilmaz R, et al. Hashimoto Tiroiditli Olgularımızın Klinik ve Laboratuvar Bulgularının Değerlendirilmesi, Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi 2015;7: 23-29 ) 12. Özsu E, Mutlu R. G. Y, Cizmeci F, Hatun Ş. Characteristics of our patients with Hashimoto thyroiditis. Turk Pediatri Arsivi-Turkish Archives Of Pediatrics, 2011;46(3):252-5 13. Radetti G, Gottardi E, Bona G, Corrias A, Salardi S, Loche S. The natural history of euthyroid Hashimoto’s thyroiditis in children. J Pediatr 2006; 149: 827-32 14. Valenzise M, Porcaro F, Zirilli G, De Luca F, Cinquegrani M, Aversa T. Hypoceruloplasminemia: an unusual biochemical finding in a girl with Hashimoto's thyroiditis and severe hypothyroidism. Pediatr Med Chir. 2018;5:40(2). doi: 10. 4081/pmc.2018.179. 15. Dundar B, Boyacı A, Sarıgün Ö, Dündar N. Hashimoto thyroidits in children and adolescents: evaluation of clinical and laboratory findings. Turk Pediatri Ars 2011;46: 318-22. 16. Ozen S, Berk O, Simsek D G, Darcan S. Clinical course of Hashimoto’s thyroiditis and effects of levothyroxine therapy on the clinical course of the disease in children and adolescents. J Clin Res Pediatr Endocrinol 2011; 3: 192-7 17. Özlük A, Abalı S, Tamer İ. The Journal of Turkish Family Physician 2017;8(3):79-82 Doi:10.15511/tjtfp.17.00379 18. Ugurluoglu C, Dobur F, Karabagli P, Celik ZE. Fine needle aspiration biopsy of thyroid nodules: cytologic and histopathologic correlation of 1096 patients. Int J Clin Exp Pathol 2015;8(11):14800–05 19. Radetti G. Clinical Aspects of Hashimoto’s Thyroiditis. Paediatric Thyroidology. Endocr Dev. Basel 2014; 26: 158–70. 20. Radetti G, Loche S, D'Antonio V, et al. Influence of Hashimoto Thyroiditis on the Development of Thyroid Nodüles and Cancer in Children and Adolescents. J Endocr Soc. 2019;3: 607-616. 21. Kaya T, Varim C, Nalbant A, Gunduz Y, Tamer A. Ultrasonographic findings of thyroid in patients with Hashimoto thyroiditis: overt hypothyroid and euthyroid. Med Glas (Zenica) 2013; 10: 343-347. 22. Tuhan H, Işık S, Abacı A,et al. Celiac disease in children and adolescents with Hashimoto Thyroiditis. Turk Pediatri Ars. 2016;51: 100-105.
Year 2019, Volume: 7 Issue: Ek - IRUPEC 2019 Kongresi Tam Metin Bildirileri, 427 - 431, 10.12.2019

Abstract

References

  • References 1. Becker KL. Principles and Practices of Endocrinology and Metabolism. Second ed. Philadelphia: J.B. Lippincott Co. 1995; 414-417. 2. Gopalakrishnan S, Marwaha RK. Juvenile Autoimmune Thyroiditis. J Pediatr Endocrinol and Metab. 2007, Cilt 20, s. 961-70. 3. Lehmann, H. W, Lutterbüse, N, Plentz, A, et al. Association of Parvovirus B19 Infection and Hashimoto’s Thyroiditis in Children. Viral Immunology, 2008;21:379-383. doi:10. 1089/vim.2008. 0001 4. Fisher DA. Thyroid disorders in childhood and adolecence. In: Sperling MA, editör. Pediatric Endocrinology. 3rd ed. Philadelphia: Saunders Elsevier, 2008; 227-53. 5. Demirbilek H, Kandemir N, Gonc EN, Ozon A, Alikasifoglu A, Yordam N. Hashimoto's thyroiditis in children and adolescents: a retrospective study on clinical, epidemiological and laboratory properties of the disease. J Pediatr Endocrinol Metab. 2007;20(11):1199-205. 6. Jeong SH, Hong HS, Lee JY. The association between thyroid echogenicity and thyroid function in pediatric and adolescent Hashimoto's thyroiditis. Medicine (Baltimore). 2019 Apr;98(14):e15055. doi: 10. 1097/MD. 0000000000015055. 7. Kabelitz M, Liesenkötter KP, Stach B, et al. The prevalence of anti-thyroid peroxidase antibodies and autoimmune thyroiditis in children and adolescents in an iodine replete area. Eur J Endocrinol 2003;148:301–307 8. Gönç N, Kandemir N. Guatr. 1. Baskı. İstanbul: Çocuk Endokrinolojisi 2013.p.345-54 9. Setian N. Hypothyroidism in children: diagnosis and treatment. J Pediatr 2007;83(5):209-16. 10. Yeşilkaya E, Belen B, Bideci A, Çamurdan O, Boyraz M, Cinaz P. Kronik otoimmün tiroiditli çocuk ve ergenlerin klinik özellikleri. Gülhane Tıp Dergisi. 2008; 50: 147-50. 11. Özer S, Sönmezgöz E, Yilmaz R, et al. Hashimoto Tiroiditli Olgularımızın Klinik ve Laboratuvar Bulgularının Değerlendirilmesi, Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi 2015;7: 23-29 ) 12. Özsu E, Mutlu R. G. Y, Cizmeci F, Hatun Ş. Characteristics of our patients with Hashimoto thyroiditis. Turk Pediatri Arsivi-Turkish Archives Of Pediatrics, 2011;46(3):252-5 13. Radetti G, Gottardi E, Bona G, Corrias A, Salardi S, Loche S. The natural history of euthyroid Hashimoto’s thyroiditis in children. J Pediatr 2006; 149: 827-32 14. Valenzise M, Porcaro F, Zirilli G, De Luca F, Cinquegrani M, Aversa T. Hypoceruloplasminemia: an unusual biochemical finding in a girl with Hashimoto's thyroiditis and severe hypothyroidism. Pediatr Med Chir. 2018;5:40(2). doi: 10. 4081/pmc.2018.179. 15. Dundar B, Boyacı A, Sarıgün Ö, Dündar N. Hashimoto thyroidits in children and adolescents: evaluation of clinical and laboratory findings. Turk Pediatri Ars 2011;46: 318-22. 16. Ozen S, Berk O, Simsek D G, Darcan S. Clinical course of Hashimoto’s thyroiditis and effects of levothyroxine therapy on the clinical course of the disease in children and adolescents. J Clin Res Pediatr Endocrinol 2011; 3: 192-7 17. Özlük A, Abalı S, Tamer İ. The Journal of Turkish Family Physician 2017;8(3):79-82 Doi:10.15511/tjtfp.17.00379 18. Ugurluoglu C, Dobur F, Karabagli P, Celik ZE. Fine needle aspiration biopsy of thyroid nodules: cytologic and histopathologic correlation of 1096 patients. Int J Clin Exp Pathol 2015;8(11):14800–05 19. Radetti G. Clinical Aspects of Hashimoto’s Thyroiditis. Paediatric Thyroidology. Endocr Dev. Basel 2014; 26: 158–70. 20. Radetti G, Loche S, D'Antonio V, et al. Influence of Hashimoto Thyroiditis on the Development of Thyroid Nodüles and Cancer in Children and Adolescents. J Endocr Soc. 2019;3: 607-616. 21. Kaya T, Varim C, Nalbant A, Gunduz Y, Tamer A. Ultrasonographic findings of thyroid in patients with Hashimoto thyroiditis: overt hypothyroid and euthyroid. Med Glas (Zenica) 2013; 10: 343-347. 22. Tuhan H, Işık S, Abacı A,et al. Celiac disease in children and adolescents with Hashimoto Thyroiditis. Turk Pediatri Ars. 2016;51: 100-105.
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Details

Primary Language English
Subjects Health Care Administration
Journal Section Congress Proceedings
Authors

Abdulvahit Aşık

Semih Bolu

Publication Date December 10, 2019
Acceptance Date January 16, 2020
Published in Issue Year 2019 Volume: 7 Issue: Ek - IRUPEC 2019 Kongresi Tam Metin Bildirileri

Cite

Vancouver Aşık A, Bolu S. Evaluatıon Of Clınıcal And Laboratory Fındıngs Of Children And Adolescent Patıents Wıth Hashımoto Thyroıdıtıs. pediatr pract res. 2019;7(Ek):427-31.