Distribution of urinary tract infection agents and evaluation of antibiotic sensitivity and resistance in children: A single centre experience

Year 2023, Volume: 11 Issue: 1, 20 - 26, 29.03.2023

Sadiye Sert , Rıfat Bülbül

https://doi.org/10.21765/pprjournal.1259343

Abstract

Aim: Urinary tract infections (UTIs) are one of the most common bacterial infections and potentially serious bacterial infection in childhood. We aimed to determine the common agents and antibiotic sensitivity and resistance status according to the results of urine culture in children diagnosed with urinary tract infection.
Materials and Methods: In this retrospective study, we evaluated causative agents and antimicrobial sensitive and resistance in positive urine isolates from the children admitted to our hospital's Pediatrics Clinic between January 2017 and August 2022.
Results: A total of 702 positive urine cultures were identified, of which 239 (34%) were from boys and 463 (66%) were from girls. The girl: boy ratio was 1.93. The median age of the patients was 1.1 years (interquartile range, 5.4). The four most frequently detected microorganisms in urine cultures were Escherichia coli (52.3%), Klebsiella pneumoniae (16.1%), Enterococcus faecalis (7.8%) and Proteus mirabilis (6.4%), respectively. Escherichia coli (9.7% vs. 42.6%) and Klebsiella pneumoniae (8.3% vs. 7.8%) were the two most common uropathogens both in boys and girls. Escherichia coli and Klebsiella pneumoniae were highly resistant to ampicillin and 3rd generation cephalosporins, while highly sensitive to aminoglycosides, meropenem and imipenem.
Conclusion: We found that E.coli was the most common uropathogen in children with UTIs consistent with the literature. We suggest that when arranging the treatment of children with urinary tract infections in our region, antibiotic resistance should be considered.

Keywords

antibiotic resistance, children, Escherichia coli, urine culture, urinary tract infection

Supporting Institution

None.

Project Number

None.

Thanks

None.

Çocuklarda idrar yolu enfeksiyonu etkenlerinin dağılımı ve antibiyotik duyarlılığı ve dirençlerinin değerlendirilmesi: Tek merkez deneyimi

Abstract

Amaç: İdrar yolu enfeksiyonları, çocukluk çağında en sık görülen ve potansiyel olarak ciddi bakteriyel enfeksiyonlardan biridir. İdrar yolu enfeksiyonu tanısı alan çocuklarda idrar kültürü sonuçlarına göre sık görülen etkenleri ve antibiyotik duyarlılık ve direnç durumlarını belirlemeyi amaçladık.
Gereç ve Yöntemler: Bu retrospektif çalışmada, Ocak 2017-Ağustos 2022 tarihleri arasında hastanemiz Çocuk Kliniği'ne başvuran çocuklardan alınan idrar izolatlarında etken maddeler ile antimikrobiyal duyarlılık ve direnç pozitifliği değerlendirildi.
Bulgular: 239 (%34) erkek, 463 (%66) kız olmak üzere toplam 702 pozitif idrar kültürü saptandı. Kız: erkek oranı 1.93 idi. Hastaların ortanca yaşı 1,1 idi (çeyrekler arası aralık, 5,4). İdrar kültürlerinde en sık saptanan dört mikroorganizma sırasıyla Escherichia coli (%52,3), Klebsiella pneumoniae (%16,1), Enterococcus faecalis (%7,8) ve Proteus mirabilis (%6,4) idi. Escherichia coli (%9,7'ye karşı %42,6) ve Klebsiella pneumoniae (%8,3'e karşı %7,8) hem erkeklerde hem de kızlarda en yaygın iki üropatojendi. Escherichia coli ve Klebsiella pneumoniae ampisilin ve 3. kuşak sefalosporinlere karşı oldukça dirençli iken, aminoglikozidler, meropenem ve imipenem'e karşı oldukça hassastır.
Sonuç: Literatürle uyumlu olarak idrar yolu enfeksiyonu geçiren çocuklarda en sık üropatojenin E.coli olduğunu bulduk. Bölgemizde idrar yolu enfeksiyonu olan çocukların tedavisi düzenlenirken antibiyotik direncinin göz önünde bulundurulmasını öneriyoruz.

Keywords

antibiyotik direnci, çocuklar, Escherichia coli, idrar kültürü, idrar yolu enfeksiyonu

Project Number

None.

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