Investigation of the Antitumoral Activity of Syringic Acid on HT-29 Cells: An In Vitro Study

Year 2023, Volume: 1 Issue: 3, 123 - 130, 31.12.2023

Feyza Burul , Öznur Altunlu , Irmak Ferah Okkay , Cemil Bayram , Fatma Yesilyurt , Ufuk Okkay

Abstract

Abstract
Colorectal cancer (CRC) is one of the most common cancers in the world with high mortality rates, and it is the second leading cause of cancer-related deaths worldwide and it is estimated that more than 930,000 deaths will occur due to CRC. In addition to genetic and environmental factors, oxidative stress, lipid peroxidation and parameter changes in the antioxidant system are among the risk factors. Syringic acid (SA) which contains polyphenolic compounds, has antioxidant, anti-lipid peroxidative and anti-cancer effects. Due to these effects, syringic acid may have a healing effect on HT-29 cells. In our study, we determined the effect of SA on cell viability on HT-29 cells with MTT, and its effects on antioxidant and oxidant parameters with TAC-TOS tests. Syringic acid decreased viability, increased TAC levels and did not cause a significant change in TOS levels in HT-29 cells. These findings may indicate that SA has curative effects on CRC. However, more studies are needed for clinical uses.

Keywords

Anticancer, Antioxidant, Colorectal cancer, HT-29 Cells, Syringic acid

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