Polyphenols in New Treatment Approaches in Age-Related Macular Degeneration

Year 2022, , 573 - 577, 20.09.2022

Akif Hakan Kurt , Cansu Kara Öztabağ , Abdulgani Kaymaz

https://doi.org/10.33631/sabd.1134234

Abstract

Age-related macular degeneration (AMD) is a retinal disease that affects millions of people world wide. It is a multi factorial disease characterized by vision loss as a result of neurogeneration of the retinal pigment epithelium (RPE) and photoreceptors of the eye. Although the prevalence of AMD, which is one of the leading causes of irreversible visual impairment in people over 65 years of age, is increasing rapidly, there is no effective treatment for vision loss. With current studies, although the pharmacotherapy of AMD is still not at the desired level, the course of the disease is slowed down by antioxidant treatments. The fact that polyphenols found in many fruits and vegetables have antioxidant properties as well as anticancer, anti-inflammatory, anti-apoptotic properties has been a hope for the prevention of AMD. Recently, studies have been published indicating a role for polyphenols in the prevention of AMD. Studies showing that polyphenols with strong antioxidant properties have neuroprotective effects on chronic inflammation and apoptotic pathways, in addition to direct ROS scavenging against oxidative damage, also support this view. In this review article, the role of polyphenols in the prevention of retinal diseases such as AMD and effective treatment approaches are discussed.

Keywords

Antioxidant, neuroprotective, oxidativestress, polyphenols, age-related macular degeneration

Yaşa Bağlı Makula Dejenerasyonunda Yeni Tedavi Yaklaşımlarında Polifenoller

Abstract

Yaşa bağlı makula dejenerasyonu (YBMD), dünya çapında milyonlarca insanı etkileyen bir retina hastalığıdır. Gözün retina pigment epiteli (RPE) ve fotoreseptörlerinin nörodejenererasyonu sonucu görme kaybı ile karakterize multifaktöriyel bir hastalıktır. 65 yaş üstü kişilerde geri dönüşü olmayan görme bozukluğunun önde gelen sebepleri arasında yer alan, YBMD’nin prevalansı hızla artmasına karşın, oluşan görme kaybının etkin bir tedavisi yoktur. Güncel çalışmalar ile, YBMD’nin farmakoterapisi hala istenen düzeyde olmasa da antioksidan tedaviler ile hastalığın seyri yavaşlatılmaktadır. Bir çok meyve ve sebzede bulunan polifenollerin antikanser, anti-inflamatuar, antiapoptotik özelliklerinin yanı sıra antioksidan özelliğe de sahip olması YBMD’nin önlenmesi için bir umut olmuştur. Son zamanlarda, polifenollerin YBMD’nin önlenmesinde rolü olduğuna işaret eden çalışmalar yayınlanmıştır. Güçlü antioksidan özelliğe sahip polifenollerin oksidatif hasara karşı doğrudan reaktif oksijen türlerini (ROS) süpürme dışında, kronik inflamasyon ve apoptotik yolaklar üzerinden nöroprotektif etkisi olduğunu gösteren çalışmalar da bu görüşü desteklemektedir. Bu derleme yazısında polifenollerin YBMD gibi retina hastalıklarının önlenmesinde ki rolü ve etkin tedavi yaklaşımları irdelenmiştir.

Keywords

Antioksidan, nöroprotektif, oksidatif stres, polifenoller, yaşa bağlı makula dejenerasyonu

References

• Wong WL, Su X, Li X, Cheung CMG, Klein R, Cheng CY, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014; 2(2): e106-16.
• Stahl A. The diagnosis and treatment of age-related macular degeneration. Dtsch Arztebl Int. 2020;117: 513-9.
• Klein R, Klein BE, Jensen SC, Meuer SM. The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology. 1997; 104(1): 7-21.
• Abdelsalam A, Priore LD, Zarbin MA. Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression. Surv Ophthalmol. 1999; 44 (1): 1-29.
• Parmet S, Lynm C, Glass RM. Age-related macular degeneration. JAMA. 2006; 295(20): 2438.
• Sarks JP, Sarks SH, Killingsworth MC. Evolution of geographic atrophy of the retinal pigment epithelium. Eye. 1988; 2(5): 552-77.
• Ferris FL, Fine SL, Hyman L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthalmol. 1984; 102: 1640-2.
• Zarbin MA. Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol. 2004; 122(4): 598-614.
• Gordois A, Cutler H, Pezzullo L. An estimation of the worldwide economic and health burden of visual impairment. Global Public Health. 2012; 7(5): 465-81.
• Calderón-Larrañaga A, Vetrano DL, Welmer AK, Grande G, Fratiglioni L, Dekhtyar S. Psychological correlates of multimorbidity and disability accumulation in older adults. Age and ageing. 2019; 48(6): 789-96.
• Al-Zamil WM, Yassin SA. Recent developments in age-related macular degeneration: a review.. Clinical interventions in aging. 2017; 12: 1313.
• Brown D, Heier JS, Boyer DS, Freund KB, Kaiser P, Sarraf JEKD. Current best clinical practices-management of neovascular AMD. J VitreoRetinal Dis. 2017; 1(5): 294-7.
• Karaçorlu SA, Karaçorlu M. Makula hastalıkları. P: Aydın P, Akova YA. editörler. Temel Göz Hastalıkları: Ankara: Güneş Tıp Kitabevleri; 2010. p. 559-73.
• Förstermann U. Nitric oxide and oxidative stress in vascular disease. Pflügers Archiv-European Journal of Physiology. 2010; 459(6): 923-39.
• Halliwell B, Gutteridge JM. The antioxidants of human extracellular fluids. Arch Biochem Biophys. 1990; 280: 1-8.
• Rana A,Samtiya M,Dhewa T,Mishra V,Aluko RE. Health benefits of polyphenols: A concise review. journal of food biochemistry. 2022; e14264.
• Kalt W, Hanneken A, Milbury P, Tremblay F. Recent research on polyphenolics in vision and eye health. Journal of Agricultural and Food Chemistry. 2010; 7(58): 4001-7.
• Kalt W, Blumberg JB, McDonald JE, Vinqvist-Tymchuk MR, Fillmore SAE, Graf BA, et al. Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs. Journal of Agricultural and Food Chemistry. 2008; 56(3): 705-12.
• Matsumoto H, Nakamura Y, Tachibanaki S, Kawamura S, Hirayama M. Stimulatory effect of cyanidin 3-glycosides on the regeneration of rhodopsin. Journal of Agricultural and Food Chemistry. 2003; 51(12): 3560-3.
• Cao X, Liu M, Tuo J, Shen D, Chan CC. The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res. 2010; 91: 15-25.
• Anand David AV, Arulmoli R, Parasuraman S. Overviews of biological importance of quercetin: a bioactive flavonoid. Pharmacogn Rev. 2016; 10: 84-9.
• Weng S, Mao L, Gong Y, Sun T, Gu Q. Role of quercetin in protecting ARPE19 cells against H2O2nduced injury via nuclear factor erythroid 2 like 2 pathway activation and endoplasmic reticulum stress inhibition. Mol Med Rep. 2017; 16: 3461-8.
• Wang Y, Kim HJ, Sparrow JR. Quercetin and cyanidin-3-glucoside protect against photooxidation and photodegradation of A2E in retinal pigment epithelial cells. Exp Eye Res. 2017; 160: 45-55.
• Dinc E, L Ayaz L, Kurt AH. Protective effect of combined caffeic acid phenethyl ester and bevacizumab against hydrogen peroxide-ınduced oxidative stress in human RPE cells.Curr Eye Res.2017; 42(12): 1659-66.
• Zhao S, Liu H, Gu L. American cranberries and health benefits - an evolving story of 25 years. Journal of the Science of Food and Agriculture. 2018 ; 100(14): 5111-6.
• Chang CH, Chiu HF, Han YC, Chen IH, Shen YC, Venkatakrishnan K, et al. Photoprotective effects of cranberry juice and its various fractions against blue light-induced impairment in human retinal pigment epithelial cells. Pharmaceutical Biology. 2016; 55(1): 571-80.
• Liu L, Wu XW. Liu L, Wu XW. Nobiletin protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damage. J Biochem Mol Toxicol. 2018; 32: e22052.
• Chan CM, Huang JH, Lin HH, Chan CM, Huang JH, Lin HH, et al. Protective effects of (-)-epigallocatechin gallate on UVA-induced damage in ARPE19 cells.. Molecular Vision. 2008; 14: 2528-34.
• Radomska-Leśniewska DM, Osiecka-Iwan A, Hyc A, Góźdź A, Dąbrowska AM and Skopiński P. Therapeutic potential of curcumin in eye diseases. Cent Eur J Immunol. 2019; 44: 181-9.
• Zhu W, Wu Y, Meng YF, Wang JY, Xu M, Tao JJ and Lu J. Effect of curcumin on aging retinal pigment epithelial cells. Drug Des Devel Ther. 2015; 9: 5337-44.
• Howell JC, Chun E, Farrell AN, Hur EY, Caroti CM, Iuvone PM and Haque R. Global microRNA expression profiling: curcumin (diferuloylmethane) alters oxidative stress-responsive microRNAs in human ARPE-19 cells. Mol Vis. 2013; 19: 544-60.
• Courtaut F, Aires V, Acar N, Bretillon L, Guerrera IC, Chhuon C, et al. Resvega, a nutraceutical omega-3/resveratrol supplementation, reduces angiogenesis in a preclinical mouse model of choroidal neovascularization. Int J Mol Sci. 2021; 22(20): 11023.