Could Hemogram Parameters Predict Extensive Pulmonary Involvement in SARS CoV-2 Infection?

Year 2022, Volume: 12 Issue: 3, 453 - 459, 20.09.2022

Zeliha Coşgun , Melike Elif Kalfaoğlu , Emine Dağıstan , Emine Özsarı , Gulali Aktas

https://doi.org/10.33631/sabd.1063607

Abstract

Aim: Since the start of the pandemic, the novel coronavirus infection SARS CoV-2 has caused huge morbidity and mortality, as well as a significant economic cost. We aimed to compare clinical and laboratory findings of the SARS CoV-2 patients with mild pulmonary involvement to those in subjects with advanced pulmonary involvement.
Material and Methods: In this study, the relationship between hemogram indices and pulmonary involvement in patients hospitalized for SARS CoV-2 infection at Bolu Abant Izzet Baysal University Hospital was investigated. We analyzed the thorax CT images of the subjects with SARS CoV-2 in present retrospective study. Radiological pattern of disease-related in the lungs, percentage of lung involvement, hemogram parameters, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), aspartate and alanine transaminases (AST and ALT), lactate dehydrogenase (LDH), D-dimer, ferritin, total bilirubin, albumin, creatinine kinase, serum creatinine in patients with advanced and mild pulmonary involvement were compared.
Results: Advanced pulmonary involvement (greater than 50%) was positively and significantly correlated with ESR, (r=0.32, p<0.001), CRP (r=0.37, p<0.001), LDH (r=0.46, p<0.001), D-dimer (r=0.19, p<0.001), ferritin (r=0.37, p<0.001), mean platelet volume (MPV) (r=0.13, p<0.001), the neutrophil to lymphocyte ratio (NLR) (r=0.33, p<0.001) and platelet to lymphocyte ratio (PLR) (r=0.27, p<0.001).
Conclusion: We suggest that MPV, PLR and NLR could be early predictors of advanced pulmonary involvement in SARS CoV-2 patients. Physicians should aware of this complication in the setting of elevated MPV, PLR or NLR levels.

Keywords

Mean platelet volume, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, pulmonary involvement, SARS Cov-2

Supporting Institution

No

Hemogram Parametreleri SARS CoV-2 Enfeksiyonunda Geniş Pulmoner Tutulumu Öngörebilir mi?

Abstract

Amaç: Pandeminin başlangıcından bu yana, yeni koronavirüs enfeksiyonu SARS CoV-2, önemli bir ekonomik maliyetin yanı sıra büyük morbidite ve mortaliteye neden oldu. Hafif pulmoner tutulumu olan SARS CoV-2 hastalarının klinik ve laboratuvar bulgularını ileri akciğer tutulumu olan deneklerle karşılaştırmayı amaçladık.
Gereç ve Yöntemler: Bu çalışmada, Bolu Abant İzzet Baysal Universitesi Hastanesi’nde SARS CoV-2 enfeksiyonu nedeniyle yatırılan hastalarda hemogram indeksleri ile akciğer tutulumu arasındaki ilişki araştırıldı. Bu retrospektif çalışmada SARS CoV-2'li olguların toraks BT görüntüleri incelendi. Akciğerlerde hastalığa bağlı radyolojik patern, akciğer tutulum yüzdesi, hemogram parametreleri, eritrosit sedimantasyon hızı (ESR), C-reaktif protein (CRP), aspartat ve alanin transaminazlar (AST ve ALT), laktat dehidrojenaz (LDH), ileri ve hafif akciğer tutulumu olan hastalarda D-dimer, ferritin, total bilirubin, albümin, kreatinin kinaz, serum kreatinin değerleri karşılaştırıldı.
Bulgular: İleri akciğer tutulumu (%50'den fazla), ESR (r=0,32, p<0,001), CRP (r=0,37, p<0,001), LDH (r=0,46, p<0,001), D-dimer (r=0,19, p<0,001), ferritin (r=0,37, p<0,001), ortalama platelet volümü (MPV) (r=0,13, p<0,001), nötrofil/lenfosit oranı (NLR) (r=0,33, p<0,001) ve platelet/lenfosit oranı (PLR) (r =0,27, p<0,001) ile pozitif ve anlamlı korelasyon gösterdi.
Sonuç: SARS CoV-2 hastalarında MPV, PLR ve NLR'nin ileri pulmoner tutulumun erken belirleyicileri olabileceğini düşünüyoruz. Doktorlar, yüksek MPV, PLR veya NLR seviyelerinde bu komplikasyonun farkında olmalıdır.

Keywords

Ortalama trombosit hacmi, nötrofil/lenfosit oranı, trombosit/lenfosit oranı, pulmoner tutulum, SARS-CoV-2

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