Investigation of the Effect of Leaky Gut on COVID-19 Clinic

Year 2022, Volume: 12 Issue: 3, 440 - 444, 20.09.2022

Cihadiye Öztürk , Banu Hümeyra Keskin , Nevin Ince , Eda Kayabaşı , Sare Kaya , Şengül Cangür , Pınar Yıldız Gülhan , Mehmet Cihat Demir

https://doi.org/10.33631/sabd.1082004

Cited By: 1

Abstract

Aim: In the course of the COVID-19 pandemic, in millions of cases were observed those of some patients do not exhibit any symptoms whereas some others are hospitalized with having fatal outcomes. One of the most significant findings is that patients with existing comorbidities are extremely exposed to severe clinical conditions developed due to excessive inflammatory response. That is to say, the indicative cause of chronic inflammation may be bacterial translocation derived from the impaired intestinal mucosal barriers.
This study is aimed to investigate the probable relations between the impaired intestinal barrier integrity and which would be associated with severity of COVID-19 clinical conditions.
Material and Methods: According to the clinical and laboratory findings, the patients were classified into three groups as mild, moderate, and severe clinical conditions. All patients’ blood samples were collected on the first admission to the hospital. Serum concentrations of lipopolysaccharide-binding protein (LBP), were analyzed to evaluate the intestinal barrier function and bacterial translocation.
Results: The proportions of those with high LBP levels among all the groups were significantly different (p<0.001). The proportion of the patients with high LBP levels in the mild patient group (65.4%) was significantly lower than those with moderate (100%) and with severe clinical conditions (95.2%) (p<0.05 for each).
Conclusion: In recent years, it has been clearly demonstrated that the functions of the intestines are much more than the digestive function, and that the intestinal microbiota and mucosal barrier integrity have a great impact on the immune system. These results would indicate that the impaired intestinal barrier integrity and bacterial translocation might be effective in severe COVID-19 development.

Keywords

Bacterial translocation, COVID-19, innate immunity, leaky gut, SARS-CoV-2

Supporting Institution

Düzce Üniversitesi Bilimsel Araştırma Projeleri

Project Number

2020.04.01.1128

Thanks

With special thanks to our proofreader Serap Yücel and Yağmur Öztürk.

Geçirgen Bağırsağın COVID-19 Kliniği Üzerinde Etkisinin Araştırılması

Abstract

Amaç: COVID-19 pandemisi sürecinde milyonlarca vakada bazı hastaların herhangi bir semptom göstermediği, bazılarının ise ölümcül sonuçla hastaneye kaldırıldığı gözlemlenmiştir. En önemli bulgulardan biri, komorbiditesi olan hastaların aşırı inflamatuvar yanıta bağlı gelişen ciddi klinik durumlara aşırı derecede maruz kalmasıdır. Yani kronik inflamasyonun belirleyici nedeni, bozulmuş bağırsak mukozal bariyerlerinden türetilen bakteriyel translokasyon olabilir.
Bu çalışma, bozulmuş bağırsak bariyeri bütünlüğü ile COVID-19 klinik durumlarının şiddeti ile ilişkilendirilebilecek olası ilişkileri araştırmayı amaçlamaktadır.
Gereç ve Yöntemler: Klinik ve laboratuvar bulgularına göre hastalar hafif, orta ve şiddetli klinik durumlar olarak üç gruba ayrılmıştır. Tüm hastalardan kan örnekleri hastaneye ilk başvurularında alınmıştır. Lipopolisakkarit bağlayıcı proteinin (LBP) serum konsantrasyonları, bağırsak bariyer fonksiyonunu ve bakteriyel translokasyonu değerlendirmek için analiz edilmiştir.
Bulgular: Tüm gruplar arasında yüksek LBP düzeyine sahip olanların oranları önemli ölçüde farklıydı (p <0,001) (Tablo 1). Hafif hasta grubunda (%65,4) yüksek LBP düzeyleri olan hastaların oranı, orta (%100) ve ciddi klinik durumları (%95,2) olanlara göre anlamlı derecede düşük bulunmuştur (her biri için p <0,05).
Sonuç: Son yıllarda bağırsakların fonksiyonlarının sindirim fonksiyonundan çok daha fazla olduğu ve ayrıca bağırsak mikrobiyotası ve mukozal bariyer bütünlüğünün bağışıklık sistemi üzerinde çok büyük etkisi olduğu açıkça ortaya konmuştur. Bu sonuçlar, bozulmuş bağırsak bariyeri bütünlüğünün ve bakteriyel translokasyonun şiddetli COVID-19 gelişiminde etkili olabileceğini düşündürmektedir.

Keywords

Bakteriyel translokasyon, COVID-19, doğal bağışıklık, geçirgen bağırsak, SARS-CoV-2

Project Number

2020.04.01.1128

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