Case Report
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HİPERTROFİK OSTEOARTROPATİ: OLGU SUNUMU

Year 2016, Volume: 1 Issue: 1, 16 - 23, 01.09.2016

Abstract

Hipertrofik Osteoartropati (HO) ilk defa Marie ve Bamberger tarafından 1889 yılında tanımlanmış
genellikle pulmoner hastalıklarla karakterize olan klinik bir tablodur (6). Klasik triadı; Parmaklarda
çomaklaşma, artrit ve özellikle uzun kemikleri tutan periostit ile bu bölgelerde baskın ağrıdır (18).
Laboratuvar bulguları altta yatan hastalığa göre değişmekle birlikte genellikle yüksek düzeyde saptanan
eritrosit sedimentasyon hızı (ESH) ve C-reaktif protein (CRP) şeklindedir (13). Her iki alt ekstremitede
ağrı ve sağ dirsekte şişlik şikayeti ile polikliniğimize başvuran 52 yaşındaki erkek hastanın fizik
muayenesi ve tetkikleri sonucu HO tanısı konuldu. Olgu literatür eşliğinde tartışıldı.

References

  • 1. Abe Y, Kurita S, Ohkubo Y, Usui H, Hashizume T, Nakamura M, Ueyama Y, Fujino T. A case of pulmonary adenocarcinima associated with hypertrophic osteoarthropathy due to vascular endothelial growth factor. Anticancer Res. 2002;22: 3485–3458.
  • 2. Altman RD, Tenenbaum J. Hypertrophic osteoarthropathy. In: Kelley W, Harris Jr ED, Ruddy S, Sledge C, editors. Textbook of rheumatology. 8th ed. Philadelphia WB Saunders; 2009. p. 1606–8.
  • 3. Amital H, Applbaum YH, Vasiliev L, Rubinow A. Hypertrophic pulmonary osteoarthropathy: control of pain and symptoms with pamidronate. Clin Rheumatol 2004;23: 330-2.
  • 4. Awerbuch MS, Brooks PM. Role of immune complexes in hypertrophic osteoarthropathy and nonmetastatic polyarthritis. Ann Rheum Dis. 1981;40: 470–2.
  • 5. Blackwell N, Bangham L, Hughes M, Melzack D, Trotman I. Treatment of resistant pain in hypertrophic pulmonary arthropathy with ketorolac. Thorax 1993;48: 401.
  • 6. C. Cruz, M. Rocha, D. Andrade, F. Guimarães, V. Silva, S. Souza, C.A. Moura, C.G. Moura. Hypertrophic pulmonary osteoarthropathy with positive antinuclear antibodies: case report. Case Rep Oncol 5: 308-312, 2012.
  • 7. Harris AW, Harding TA, Gaitonde MD, Maxwell JD. Is clubbing a feature of the antiphospholipid antibody syndrome? Postgrad Med J. 1993;69: 748–50.
  • 8. Kishi K, Nakamura H, Sudo A, Kobayashi K, Yagyu H, Oh-ishi S, Matsuoka T. Tumor debulking by radiofrequency ablation in hypertrophic pulmonary osteoarthropathy associated pulmonary carcinoma. Lung Cancer. 2002;38: 317–320.
  • 9. Kozak KR, Milne GL, Morrow JD, Cuiffo BP. Hypertrophic osteoarthropathy pathogenesis: a case highlighting the potential role for cyclo-oxygenase-2-derived prostaglandin E2. Nat Clin Pract Rheumatol 2006;2: 452-6.
  • 10. Matucci-Cerinic M, Martinez-Lavin M, Rojo F, Fonseca C, Kahaleh BM. Von Willebrand factor antigen in hypertrophic osteoarthropathy. J Rheumatol. 1992;19: 765–7.
  • 11. Milman E, Berdon WE, Garvin JH, Cairo MS, Bessmertny O, Ruzal-Shapiro C. Periostitis secondary to interleukin-11 (Oprelvekin, Neumega) Treatment for thrombocytopenia in pediatric patients. Pediatr Radiol. 2003;33: 450–2.
  • 12. Mito K, Maruyama R, Uenishi Y, et al. Hypertrophic pulmonary osteoarthropathy associated with non-small cell lung cancer demonstrated growth hormone-releasing hormone by immunohistochemical analysis. Intern Med. 2001;40: 532–535.
  • 13. Morgan B, Coakley F, Finlay DB, Belton I. Hypertrophic osteoarthropathy in staging skeletal scintigraphy for lung cancer. Clin Radiol. 1996;51: 694–647. 23
  • 14. Nomori H, Kobayashi R, Kubo A, Morinaga S, Shintani Y, Sano T . Lung cancer containing growth hormone-releasing hormone associated with hypertrophic osteoarthropathy. Case report. Scand J Thorac Cardiovasc Surg. 1994; 28: 149–152.
  • 15. Ooi A, Saad RA, Moorjani N, Amer KM. Effective symptomatic relief of hypertrophic pulmonary osteoarthropathy by video-assisted thoracic surgery truncal vagotomy. Ann Thorac Surg 2007;83: 684-5.
  • 16. Shih WJ. Pulmonary hypertrophic osteoarthropathy and its resolution. Semin Nucl Med 2004;34: 159-63.
  • 17. Silveira LH, Martínez-Lavín M, Pineda C, Fonseca MC, Navarro C, Nava A. Vascular endothelial growth factor and hypertrophic osteoarthropathy. Clin Exp Rheumatol 2000;18: 57-62.
  • 18. Vogl A, Goldfischer S. Pachydermoperiostosis. Primary or idiopathic hypertrophic osteoarthropathy. Am J Med 1962;33: 166-87.
  • 19. Yacoub MH. Cervical vagotomy for pulmonary osteoarthropathy. Br J Dis Chest. 1965;59: 28–31. ERÇALIK, ÇELEBİ, DÜDEN, ELİK, OJALVO, YILMAZ, ÖNCÜ,

HYPERTROPHIC OSTEOARTHROPATHY: A CASE REPORT

Year 2016, Volume: 1 Issue: 1, 16 - 23, 01.09.2016

Abstract

Hypertrophic osteoarthropathy (HO) is a disorder which has been defined for the first time in 1889 by
Marie and Bamberger. It is usually characterized by clinical pulmonary disease (6). Classical triad includes
finger clubbing, arthritis and pain caused by periostitis especially in the long bones (18). Laboratory findings
vary according to the underlying disease and usually high levels of erythrocyte sedimentation rate
and C-reactive protein exist (13). A 52 year old male patient with bilateral lower extremity pain and swelling
in his right elbow was admitted to our hospital. After physical examination and laboratory results,
HO was diagnosed. The patient is discussed under the light of the current literature. 

References

  • 1. Abe Y, Kurita S, Ohkubo Y, Usui H, Hashizume T, Nakamura M, Ueyama Y, Fujino T. A case of pulmonary adenocarcinima associated with hypertrophic osteoarthropathy due to vascular endothelial growth factor. Anticancer Res. 2002;22: 3485–3458.
  • 2. Altman RD, Tenenbaum J. Hypertrophic osteoarthropathy. In: Kelley W, Harris Jr ED, Ruddy S, Sledge C, editors. Textbook of rheumatology. 8th ed. Philadelphia WB Saunders; 2009. p. 1606–8.
  • 3. Amital H, Applbaum YH, Vasiliev L, Rubinow A. Hypertrophic pulmonary osteoarthropathy: control of pain and symptoms with pamidronate. Clin Rheumatol 2004;23: 330-2.
  • 4. Awerbuch MS, Brooks PM. Role of immune complexes in hypertrophic osteoarthropathy and nonmetastatic polyarthritis. Ann Rheum Dis. 1981;40: 470–2.
  • 5. Blackwell N, Bangham L, Hughes M, Melzack D, Trotman I. Treatment of resistant pain in hypertrophic pulmonary arthropathy with ketorolac. Thorax 1993;48: 401.
  • 6. C. Cruz, M. Rocha, D. Andrade, F. Guimarães, V. Silva, S. Souza, C.A. Moura, C.G. Moura. Hypertrophic pulmonary osteoarthropathy with positive antinuclear antibodies: case report. Case Rep Oncol 5: 308-312, 2012.
  • 7. Harris AW, Harding TA, Gaitonde MD, Maxwell JD. Is clubbing a feature of the antiphospholipid antibody syndrome? Postgrad Med J. 1993;69: 748–50.
  • 8. Kishi K, Nakamura H, Sudo A, Kobayashi K, Yagyu H, Oh-ishi S, Matsuoka T. Tumor debulking by radiofrequency ablation in hypertrophic pulmonary osteoarthropathy associated pulmonary carcinoma. Lung Cancer. 2002;38: 317–320.
  • 9. Kozak KR, Milne GL, Morrow JD, Cuiffo BP. Hypertrophic osteoarthropathy pathogenesis: a case highlighting the potential role for cyclo-oxygenase-2-derived prostaglandin E2. Nat Clin Pract Rheumatol 2006;2: 452-6.
  • 10. Matucci-Cerinic M, Martinez-Lavin M, Rojo F, Fonseca C, Kahaleh BM. Von Willebrand factor antigen in hypertrophic osteoarthropathy. J Rheumatol. 1992;19: 765–7.
  • 11. Milman E, Berdon WE, Garvin JH, Cairo MS, Bessmertny O, Ruzal-Shapiro C. Periostitis secondary to interleukin-11 (Oprelvekin, Neumega) Treatment for thrombocytopenia in pediatric patients. Pediatr Radiol. 2003;33: 450–2.
  • 12. Mito K, Maruyama R, Uenishi Y, et al. Hypertrophic pulmonary osteoarthropathy associated with non-small cell lung cancer demonstrated growth hormone-releasing hormone by immunohistochemical analysis. Intern Med. 2001;40: 532–535.
  • 13. Morgan B, Coakley F, Finlay DB, Belton I. Hypertrophic osteoarthropathy in staging skeletal scintigraphy for lung cancer. Clin Radiol. 1996;51: 694–647. 23
  • 14. Nomori H, Kobayashi R, Kubo A, Morinaga S, Shintani Y, Sano T . Lung cancer containing growth hormone-releasing hormone associated with hypertrophic osteoarthropathy. Case report. Scand J Thorac Cardiovasc Surg. 1994; 28: 149–152.
  • 15. Ooi A, Saad RA, Moorjani N, Amer KM. Effective symptomatic relief of hypertrophic pulmonary osteoarthropathy by video-assisted thoracic surgery truncal vagotomy. Ann Thorac Surg 2007;83: 684-5.
  • 16. Shih WJ. Pulmonary hypertrophic osteoarthropathy and its resolution. Semin Nucl Med 2004;34: 159-63.
  • 17. Silveira LH, Martínez-Lavín M, Pineda C, Fonseca MC, Navarro C, Nava A. Vascular endothelial growth factor and hypertrophic osteoarthropathy. Clin Exp Rheumatol 2000;18: 57-62.
  • 18. Vogl A, Goldfischer S. Pachydermoperiostosis. Primary or idiopathic hypertrophic osteoarthropathy. Am J Med 1962;33: 166-87.
  • 19. Yacoub MH. Cervical vagotomy for pulmonary osteoarthropathy. Br J Dis Chest. 1965;59: 28–31. ERÇALIK, ÇELEBİ, DÜDEN, ELİK, OJALVO, YILMAZ, ÖNCÜ,
There are 19 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Articles
Authors

Cem Erçalık

Göksel Çelebi This is me

Bilge Düden This is me

Hüseyin Elik This is me

David Ojalvo This is me

Figen Yılmaz This is me

Jülide Öncü

Gülgün Durlanık This is me

Beril Doğu

Banu Kuran This is me

Fatih Borlu This is me

Publication Date September 1, 2016
Published in Issue Year 2016 Volume: 1 Issue: 1

Cite

APA Erçalık, C., Çelebi, G., Düden, B., Elik, H., et al. (2016). HİPERTROFİK OSTEOARTROPATİ: OLGU SUNUMU. Sağlık Bilimleri Ve Yaşam Dergisi, 1(1), 16-23.
AMA Erçalık C, Çelebi G, Düden B, Elik H, Ojalvo D, Yılmaz F, Öncü J, Durlanık G, Doğu B, Kuran B, Borlu F. HİPERTROFİK OSTEOARTROPATİ: OLGU SUNUMU. SBYD. September 2016;1(1):16-23.
Chicago Erçalık, Cem, Göksel Çelebi, Bilge Düden, Hüseyin Elik, David Ojalvo, Figen Yılmaz, Jülide Öncü, Gülgün Durlanık, Beril Doğu, Banu Kuran, and Fatih Borlu. “HİPERTROFİK OSTEOARTROPATİ: OLGU SUNUMU”. Sağlık Bilimleri Ve Yaşam Dergisi 1, no. 1 (September 2016): 16-23.
EndNote Erçalık C, Çelebi G, Düden B, Elik H, Ojalvo D, Yılmaz F, Öncü J, Durlanık G, Doğu B, Kuran B, Borlu F (September 1, 2016) HİPERTROFİK OSTEOARTROPATİ: OLGU SUNUMU. Sağlık Bilimleri ve Yaşam Dergisi 1 1 16–23.
IEEE C. Erçalık, “HİPERTROFİK OSTEOARTROPATİ: OLGU SUNUMU”, SBYD, vol. 1, no. 1, pp. 16–23, 2016.
ISNAD Erçalık, Cem et al. “HİPERTROFİK OSTEOARTROPATİ: OLGU SUNUMU”. Sağlık Bilimleri ve Yaşam Dergisi 1/1 (September 2016), 16-23.
JAMA Erçalık C, Çelebi G, Düden B, Elik H, Ojalvo D, Yılmaz F, Öncü J, Durlanık G, Doğu B, Kuran B, Borlu F. HİPERTROFİK OSTEOARTROPATİ: OLGU SUNUMU. SBYD. 2016;1:16–23.
MLA Erçalık, Cem et al. “HİPERTROFİK OSTEOARTROPATİ: OLGU SUNUMU”. Sağlık Bilimleri Ve Yaşam Dergisi, vol. 1, no. 1, 2016, pp. 16-23.
Vancouver Erçalık C, Çelebi G, Düden B, Elik H, Ojalvo D, Yılmaz F, Öncü J, Durlanık G, Doğu B, Kuran B, Borlu F. HİPERTROFİK OSTEOARTROPATİ: OLGU SUNUMU. SBYD. 2016;1(1):16-23.