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Nükleer Tıpta Kullanılan Bakır Radyoizotoplarının Uyarma Fonksiyonlarının TALYS Kodu ile İncelenmesi

Year 2017, Volume: 12 Issue: 2, 12 - 18, 30.11.2017

Abstract

60,61,62,64,67Cu radyoizotopları,
nükleer tıpta tanı veya terapi amaçlı olarak çeşitli uygulamalar için kullanılır.
Bu radyoizotopların geniş yarı ömür spektrumu çeşitli radyofarmasötiklerin
tasarımını ve sentezini sağlamaktadır. Kullanılabilirlik ve üretim maliyeti
nedeniyle, bakır radyofarmasötiklerindeki araştırma çabaları, esas olarak, bu
süreçte tasarlanan üretkenliğin olasılığını gösteren reaksiyon kesitlerinin
hesaplanmasına odaklanmıştır. Bu çalışmada bakır radyoizotopların uyarma
fonksiyonları, 50 MeV’e kadar parçacık gelme enerjisinde TALYS nükleer
reaksiyon kodu kullanılarak reaksiyon tesir kesitlerinin teorik olarak
hesaplanması ile araştırılmıştır.

References

  • C.J. Anderson and R. Ferdani, “Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research,” Cancer Biotheraphy and Radiopharmaceuticals, vol. 24 (4), pp. 379-392, 2009.
  • A.R. Jalilian and J. Osso Jr., “The current status and future of theranostic Copper-64 radiopharmaceuticals,” Iran J Nucl Med, vol. 25(1), pp. 1-10, 2017.
  • S.M. Qaim, “Use of cyclotrons in medicine,” Radiation Physics and Chemistry, vol. 71, pp. 917–926, 2004.
  • B.L. Zhuikov, “Production of medical radionuclides in Russia: Status and future—a review,” Applied Radiation and Isotopes, vol. 84, pp. 48–56, 2004.
  • B. Demir, V. Çapalı, İ.H. Sarpün, A. Kaplan, “Production Cross–Section Calculations of Medical 125I Radionuclide Using α, d and γ Induced Reactions” SDU Journal of Science (E-Journal), vol. 10 (2), pp. 116-121, 2015.
  • B. Demir, A. Kaplan, V. Çapalı, İ. H. Sarpün, A. Aydın, E. Tel, “Production cross–section calculations of medical 32P, 117Sn, 153Sm and 186,188Re radionuclides used in bone pain palliation treatment,” Kerntechnik, vol. 80(1), pp. 58–65, 2015.
  • R. Ünal, İ.H. Sarpün, H.A. Yalım, “Comparison of level density models in (γ, n) reactions of some lanthanide nuclei,” Physics of Atomic Nuclei, vol. 77 (3), pp. 310-315, 2014.
  • H.A. Yalım, A. Aydin, İ.H. Sarpün, R. Ünal, B. Oruncak, A. Kaplan, E. Tel, “Investigation of Nucleon Mean Free Path Dependence in Tritium Emission Spectra Produced by Proton Induced Reactions at 62 MeV,” Journal of Fusion Energy, vol. 29 (1), pp. 55-61, 2010.
  • İ.H. Sarpün, H.A. Yalım, R. Ünal, B. Oruncak, A. Aydın, A. Kaplan, E. Tel, “Determination of (n, 2n) Reaction Cross Sections for Some Nuclei with Asymmetry Parameter,” Journal of Fusion Energy, vol. 29 (4), pp. 387-394, 2010.
  • A. Aydin, H.A. Yalim, E. Tel, B. Şarer, R. Ünal, İ.H. Sarpün, A. Kaplan, M. Dağ, “Level density parameter dependence of the fission cross sections of some subactinide nuclei induced by protons with the incident energy up to 250MeV,” Annals of Nuclear Energy, 36 (9), pp. 1307-1312, 2009.
  • A. Kaplan, “Investigation of Neutron-Production Cross Sections of the Structural Fusion Material 181Ta for (α,xn) Reactions up to 150 MeV Energy,” Journal of Fusion Energy, vol. 32 (3), pp. 382–388, 2013.
  • U. Akçaalan, R. Ünal, İ.H. Sarpün, H.A. Yalim, B. Oruncak, “Calculations of (γ, n) Reaction Cross Sections using Different Level Density Models for Some Lanthanide Nuclei,” Acta Physica Polonica A, 128 (B-2), pp. 228-230, 2015.
  • Koning A., Hilaire S., Goriely S., “TALYS–1.6 A Nuclear Reaction Program, User Manual (NRG, The Netherlands),” First Edition, vol. 23, pp. 64–67, 2013.
  • EXFOR/CSISRS, Brookhaven National Laboratory, National Nuclear Data Center, Database Version of April 2017.

Investigation of Excitation Functions of Copper Radioisotopes Used in Nuclear Medicine with TALYS Code

Year 2017, Volume: 12 Issue: 2, 12 - 18, 30.11.2017

Abstract
















60,61,62,64,67Cu radioisotopes of copper are used for various applications in diagnostic
or therapeutic nuclear medicine. These radioisotopes’ wide range of half-lives
enable designing and
synthesizing of various radiopharmaceuticals. Because of availability and cost of
production, the research efforts in copper radiopharmaceuticals are focused on the
calculations of reaction cross sections showing the possibility of the
productivity in this process. In this paper, excitation functions of copper
radioisotopes have been investigated through the theoretical calculation of
reaction cross sections by using TALYS nuclear reaction code in the incident
particle energy up to 50 MeV.
    

References

  • C.J. Anderson and R. Ferdani, “Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research,” Cancer Biotheraphy and Radiopharmaceuticals, vol. 24 (4), pp. 379-392, 2009.
  • A.R. Jalilian and J. Osso Jr., “The current status and future of theranostic Copper-64 radiopharmaceuticals,” Iran J Nucl Med, vol. 25(1), pp. 1-10, 2017.
  • S.M. Qaim, “Use of cyclotrons in medicine,” Radiation Physics and Chemistry, vol. 71, pp. 917–926, 2004.
  • B.L. Zhuikov, “Production of medical radionuclides in Russia: Status and future—a review,” Applied Radiation and Isotopes, vol. 84, pp. 48–56, 2004.
  • B. Demir, V. Çapalı, İ.H. Sarpün, A. Kaplan, “Production Cross–Section Calculations of Medical 125I Radionuclide Using α, d and γ Induced Reactions” SDU Journal of Science (E-Journal), vol. 10 (2), pp. 116-121, 2015.
  • B. Demir, A. Kaplan, V. Çapalı, İ. H. Sarpün, A. Aydın, E. Tel, “Production cross–section calculations of medical 32P, 117Sn, 153Sm and 186,188Re radionuclides used in bone pain palliation treatment,” Kerntechnik, vol. 80(1), pp. 58–65, 2015.
  • R. Ünal, İ.H. Sarpün, H.A. Yalım, “Comparison of level density models in (γ, n) reactions of some lanthanide nuclei,” Physics of Atomic Nuclei, vol. 77 (3), pp. 310-315, 2014.
  • H.A. Yalım, A. Aydin, İ.H. Sarpün, R. Ünal, B. Oruncak, A. Kaplan, E. Tel, “Investigation of Nucleon Mean Free Path Dependence in Tritium Emission Spectra Produced by Proton Induced Reactions at 62 MeV,” Journal of Fusion Energy, vol. 29 (1), pp. 55-61, 2010.
  • İ.H. Sarpün, H.A. Yalım, R. Ünal, B. Oruncak, A. Aydın, A. Kaplan, E. Tel, “Determination of (n, 2n) Reaction Cross Sections for Some Nuclei with Asymmetry Parameter,” Journal of Fusion Energy, vol. 29 (4), pp. 387-394, 2010.
  • A. Aydin, H.A. Yalim, E. Tel, B. Şarer, R. Ünal, İ.H. Sarpün, A. Kaplan, M. Dağ, “Level density parameter dependence of the fission cross sections of some subactinide nuclei induced by protons with the incident energy up to 250MeV,” Annals of Nuclear Energy, 36 (9), pp. 1307-1312, 2009.
  • A. Kaplan, “Investigation of Neutron-Production Cross Sections of the Structural Fusion Material 181Ta for (α,xn) Reactions up to 150 MeV Energy,” Journal of Fusion Energy, vol. 32 (3), pp. 382–388, 2013.
  • U. Akçaalan, R. Ünal, İ.H. Sarpün, H.A. Yalim, B. Oruncak, “Calculations of (γ, n) Reaction Cross Sections using Different Level Density Models for Some Lanthanide Nuclei,” Acta Physica Polonica A, 128 (B-2), pp. 228-230, 2015.
  • Koning A., Hilaire S., Goriely S., “TALYS–1.6 A Nuclear Reaction Program, User Manual (NRG, The Netherlands),” First Edition, vol. 23, pp. 64–67, 2013.
  • EXFOR/CSISRS, Brookhaven National Laboratory, National Nuclear Data Center, Database Version of April 2017.
There are 14 citations in total.

Details

Primary Language Turkish
Subjects Metrology, Applied and Industrial Physics
Journal Section Makaleler
Authors

Hüseyin Ali Yalım

Niyazi Balçın This is me

İsmail Hakkı Sarpün This is me

Publication Date November 30, 2017
Published in Issue Year 2017 Volume: 12 Issue: 2

Cite

IEEE H. A. Yalım, N. Balçın, and İ. H. Sarpün, “Nükleer Tıpta Kullanılan Bakır Radyoizotoplarının Uyarma Fonksiyonlarının TALYS Kodu ile İncelenmesi”, Süleyman Demirel University Faculty of Arts and Science Journal of Science, vol. 12, no. 2, pp. 12–18, 2017.