2.45 gigahertz elektromanyetik radyasyonun böbrekteki histopatolojik etkileri ve C vitamininin koruyucu etkisi

Year 2018, Volume: 9 Issue: 4, 1 - 5, 25.12.2018

Ercan Baş , Murat Uçar , Funda Yıldırım Baş , Şükriye Yeşilot , İlkay Armağan , Arzu Yalçın

https://doi.org/10.22312/sdusbed.479744

Abstract

Amaçlar: Elektromanyetik radyasyonun (EMR) sıçan böbreğinde yol
açtığı histopatolojik hasarı ve C vitamininin (askorbik asit) oluşan bu renal
hasara karşı iyileştirici etkilerini araştırmak.

Gereç ve Yöntemler: On sekiz dişi Sprague-Dawley sıçanı, her biri altı
sıçan olmak üzere üç gruba ayrıldı. Grup 1 şam grubuydu; bu sıçanlar herhangi bir stres
veya elektromanyetik radyasyona maruz kalmadan kafeslerinde tutuldu. Grup 2, 30
gün boyunca 2.45 gigahertz elektromanyetik radyasyona maruz bırakıldı. Grup 3
de 30 gün boyunca (günde 1 saat) 2.45 gigahertz elektromanyetik radyasyona
maruz bırakıldı, ancak ilk maruziyetinden 24 saat önce ve deney boyunca her gün
C vitamini verildi. Tüm sıçanlara histopatolojik inceleme için nefrektomi
yapıldı.

Bulgular: Şam grubunda herhangi bir patolojik değişiklik olmadı.
Grup 2’de tübüler ve glomerüler hasarı içeren önemli patolojik değişiklikler
izlendi (P<0.05). İnterstisyel ve vasküler hasar açısından grup 2 ve 3’te
önemli bir değişiklik izlenmedi (P>0.05). Tübüler ve glomerüler hasar grup
3’te grup 2’ye göre daha az şiddetliydi (P<0.05). Şam grubu ve grup 3
arasında tübüler, glomerüler, interstisyel ve vasküler hasar açısından önemli
bir farklılık izlenmedi (P>0.05).

Sonuç: Elektromanyetik radyasyonun böbrekte yol açtığı
tübüler ve glomerüler hasar, elektromanyetik radyasyon maruziyeti öncesi alınan
C vitamini ile neredeyse tamamen normale dönmektedir.

Keywords

Antioksidanlar, Askorbik asit, Elektromanyetik radyasyon, Böbrek, Oksidatif stres

Histopathological Effects of 2.45 Gigahertz Electromagnetic Radiation on the Kidney, and Protective Effects of Vitamin C

Abstract

Objectives: To investigate the effects of electromagnetic
radiation (EMR) on the kidneys based on histopathological changes of renal
damage, and to investigate the ameliorating effects of vitamin C (ascorbic
acid) against EMR-induced renal damage in rats.

Materials
and Methods: Eighteen female Sprague-Dawley rats were divided into
three groups of six rats each. Group 1 was the sham group; these rats were kept
in their cages without stress or electromagnetic radiation exposure. Group 2
was exposed to 2.45 gigahertz electromagnetic radiation for 30 days. Group 3
was also exposed to 2.45 gigahertz electromagnetic radiation for 30 days (1
h/day) but received vitamin C 24 hours prior to the first exposure and daily
throughout the experiment. All rats underwent nephrectomy with
histopathological examination.

Results: There were no pathological findings in the sham
group. Significant pathological changes were observed in group 2, including
tubular and glomerular damage (P<0.05). Interstitial and vascular damage was
not significantly different between groups 2 and 3 (P>0.05). Tubular and glomerular damage was less severe in group
3 than in group 2 (P<0.05). There was no
significant difference between the sham group and group 3 in terms of tubular,
glomerular, interstitial, or vascular damage (P>0.05).

Conclusion: Electromagnetic radiation-induced tubular and
glomerular damage in the kidney was almost completely reversed with the administration
of vitamin C before electromagnetic radiation exposure.

Keywords

Antioxidants, Ascorbic Acid, Electromagnetic Radiation, Kidney, Oxidative stress

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