Can Neutrophil Lymphocyte Ratio Predict the Thrombus Localization in Patient with Acute Pulmonary Embolism?

Year 2019, Volume: 10 Issue: 2, 115 - 119, 16.06.2019

Cihan Bedel , Mustafa Korkut

https://doi.org/10.22312/sdusbed.513295

Abstract

Objective: Acute
pulmonary embolism (PE), often seen in the emergency department, is a life
threatening disease. The aim of this study was to determine the associations of
thrombus localization with white blood
cell (WBC) subtypes, including the neutrophil lymphocyte ratio (NLR).

Material-Method:We
retrospectively analysed the data of patients who were diagnosed with acute
PE  admitted from 1 January 2017 to 30
June 2018. The accompanying disorders, risk factors, clinical, laboratory and
radiological findings were retrospectively evaluated.

Results: The
mean age of the patients was 63.40±17.11
years and 119 (53.1%) patients were female. The most frequent complaint was
dyspnea (62.5%), most frequent coexisting disease was chronic obstructive
pulmonary disease (30.4%), immobilization (21.4%) was the most frequently seen
risk factor. Thrombus was mostly in bilateral pulmonary artery (PA) (45.9%). In
46.4% of the patients, the thrombus was localized to the lobar PA. The mean
WBC, neutrophil,  platelet
distribution width  and  NLR
in the patients with thrombus in the main PA were higher than those in the
patients with thrombus in more distal PA branches. The parameter with the highest sensitivity and specificity was found
as NLR.

Conclusions:
High NLR  is independently associated
with proximally localized thrombus in patients with PE.

Keywords

Pulmonary embolism, neutrophil lymphocyte ratio

Can Neutrophil Lymphocyte Ratio Predict the Thrombus Localization in Patient with Acute Pulmonary Embolism?

Abstract

Amaç:
Acil serviste sıklıkla görülen akut pulmoner emboli (PE) hayatı tehdit edici
bir hastalıktır. Bu çalışmanın amacı, nötrofil lenfosit oranı (NLR) dahil olmak
üzere trombüs lokalizasyonunun beyaz kan hücresi (WBC) alt tipleri ile
ilişkilerini belirlemektir.

Materyal-Metot: 1
Ocak 2017 - 30 Haziran 2018 tarihleri ​​arasında başvuran akut PE tanısı alan
hastaların verilerini retrospektif olarak inceledik. Eşlik eden hastalıklar,
risk faktörleri, klinik, laboratuvar ve radyolojik bulgular değerlendirildi.

Bulgular:
Hastaların yaş ortalaması 63,40 ± 17,11 idi  ve hastların 119'u (% 53,1) kadındı. En sık
görülen şikayet dispne (% 62,5), en sık eşlik eden hastalık kronik obstrüktif
akciğer hastalığı (% 30,4) ve immobilizasyon (% 21,4) en sık görülen risk
faktörü idi. Trombüs çoğunlukla bilateral pulmoner arterde (PA) (% 45,9) idi.
Hastaların % 46,4'ünde trombüs, lober PA'da lokalize edildi. Ana PA'da trombüs
olan hastalarda ortalama WBC, nötrofil, trombosit dağılım genişliği ve NLR,
daha distal PA dallarında trombüs olanlara göre daha yüksekti. Hassasiyeti ve
özgüllüğü en yüksek olan parametre NLR olarak bulundu.

Sonuç:
Yüksek NLR, PE'li hastalarda proksimal lokalize trombüs ile bağımsız olarak
ilişkilidir.

Keywords

Pulmoner emboli, nötrofil lenfosit oranı

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