Endodontik Doku Mühendisliğinde Nanoteknolojinin Kullanımı

Yıl 2020, Cilt: 11 Sayı: 1, 107 - 111, 03.03.2020

Güzin Tülü , Bulem Üreyen Kaya

Öz

Günümüzde halen çürük, periodontal hastalık,
travma, vb. sebeplerle çok sayıda diş kaybedilmektedir. Kaybedilen diş ya da
diş dokularının doğal haliyle yerine konulabilmesi ve bu şekilde fonksiyonunu
sürdürebilmesi fikri önemlidir. Bir dişin bütünüyle hem yapısal olarak sağlıklı
hem de fonksiyonel olacak şekilde, belirli bir dokusunun
(mine-dentin-pulpa-sement) ya da çevre dokunun (kemik-periodontal ligament)
rejenerasyonu sağlanabilmektedir. Son yıllarda nanoteknoloji alanındaki
gelişmelerle birlikte, doku mühendisliğinde kullanılan bazı materyallerin nano
boyutta sentezlenerek kullanılması ile ilgili bir çok çalışma yapılmaktadır. Bu
derlemenin amacı endodontide doku mühendisliği alanındaki nanoteknolojik
gelişmeleri incelemektir.

Anahtar Kelimeler

doku mühendisliği, nanoteknoloji

Teşekkür

Bu derlemede makalenin yazarlarından biri olan Güzin Tülü’nün “Gümüş Nanopartikülü İlave Edilmiş Kanal İçi Medikamentlerin Çok Türlü Biyofilm Üzerine Antibakteriyel Etkinliklerinin Karşılaştırılması- Ex Vivo Çalışma” isimli uzmanlık tezinden yararlanılmıştır.

Nanotechnological Developments In Tissue Engineering In Endodontics

Öz

Today,
many teeth are still lost due to caries, periodontal disease, trauma, etc. The
idea that the lost tooth or tooth tissues can be replaced in its natural state
and that it can function in this way, is important. Regeneration of a
particular tissue (enamel-dentin-pulp-cement) or surrounding tissue
(bone-periodontal ligament) can be achieved structurally healthy and functional.
In recent years, with the advances in nanotechnology, there are many studies
about the synthesis of some materials used in tissue engineering at nano scale.
The aim of this review is to investigate the nanotechnological developments in
tissue engineering in endodontics

Anahtar Kelimeler

nanotechnology, tissue engineering

Kaynakça

• Çıracı S. [Metrenin Bir Milyarda Birinde Bilim ve Teknoloji]. Bilim ve Teknik. 2005; (Ağustos-2005 eki): 6-10.
• Bumb SS, Bhaskar DJ, Punia H. Nanorobots and challenges faced by nanodentistry. Guident. 2013; 6(10):67-9.
• Aeran H, Kumar V, Uniyal S, Tanwer P. Nanodentistry: Is just a fiction or future. J Oral Biol Craniofac Res. 2015; 5(3): 207–11.
• Freitas RA. Nanodentistry. J Am Dent Assoc. 2000;131(11): 1559-65.
• Drexler KE. Nanosystems: Molecular machinery, manufacturing and computation. 1st ed. Chichester, UK: Wiley & Sons; 1992. P. 556.
• Sharma S, Srivastava D, Grover S, Sharma V. Biomaterials in Tooth Tissue Engineering: A Review. J Clin Diagn Res. 2014; 8(1): 309–15.
• Akca Can C, Duran D. [Doku Muhendisliği Uygulamalarında Tekstil Materyal Ve Teknolojilerinin Kullanımı]. Tekstil Teknolojileri Elektronik Dergisi. 2009; 3(1): 77-86.
• Seo SJ, Kim HW, Lee JH. Electrospun Nanofibers Applications in Dentistry. J Nanomater. 2016; Article ID: 5931946, 7 pages.
• Wang J, Liu X, Jin X, Ma H, Hu J, Ni L, Ma PX. The odontogenic differentiation of human dental pulp stem cells on nanofibrous poly(L-lactic acid) scaffolds in vitro and in vivo. Acta Biomater. 2010; 6(10): 3856-63.
• Wang J, Ma H, Jin X, Hu J, Liu X, Ni L, Ma PX. The effect of scaffold architecture on odontogenic differentiation of human dental pulp stem cells. Biomaterials. 2011; 32(31): 7822-30.
• Kuang R, Zhang Z, Jin X, Hu J, Gupte MJ, Ni L, Ma PX. Nanofibrous spongy microspheres enhance odontogenic differentiation of human dental pulp stem cells. Adv Healthc Mater. 2015 ;4(13): 1993-2000.
• Li WJ, Laurencin CT, Caterson EJ, Tuan RS, Ko FK. Electrospun nanofibrous structure: a novel scaffold for tissue engineering. J Biomed Mater Res. 2002; 60(4): 613-21.
• Yang X, Yang F, Walboomers XF, Bian Z, Fan M, Jansen JA. The performance of dental pulp stem cells on nanofibrous PCL/gelatin/nHA scaffolds. J Biomed Mater Res A. 2010; 93(1): 247-57.
• Guo T, Li Y, Cao G, Zhang Z, Chang S, Czajka-Jakubowska A, Nör JE, Clarkson BH, Liu J. Fluorapatite-modified scaffold on dental pulp stem cell mineralization. J Dent Res. 2014; 93(12):1290-5.
• Dreesmann L, Mittnacht U, Lietz M, Schlosshauer B. Nerve fibroblast impact on Schwann cell behavior. Eur J Cell Biol. 2009; 88(5): 285-300.
• Liu L, Shu S, Cheung GS, Wei X. Effect of miR-146a/bFGF/PEG-PEI Nanoparticles on Inflammation Response and Tissue Regeneration of Human Dental Pulp Cells. Biomed Res Int. 2016; 2016: 3892685.
• Bellamy C, Shrestha S, Torneck C, Kishen A. Effects of a Bioactive Scaffold Containing a Sustained Transforming Growth Factor-β1-releasing Nanoparticle System on the Migration and Differentiation of Stem Cells from the Apical Papilla. J Endod. 2016; 42(9): 1385-92.
• Shrestha S, Torneck CD, Kishen A. Dentin Conditioning with Bioactive Molecule Releasing Nanoparticle System Enhances Adherence, Viability, and Differentiation of Stem Cells from Apical Papilla. J Endod. 2016 ; 42(5): 717-23.
• Shrestha S, Diogenes A, Kishen A. Temporal-controlled dexamethasone releasing chitosan nanoparticle system enhances odontogenic differentiation of stem cells from apical papilla. J Endod. 2015; 41: 1253–8.
• Kaushik SN, Scoffield J, Andukuri A, Alexander GC, Walker T, Kim S, et al. Evaluation of ciprofloxacin and metronidazole encapsulated biomimetic nanomatrix gel on Enterococcus faecalis and Treponema denticola. Biomater Res. 2015; 19: 9.
• Bottino MC, Kamocki K, Yassen GH, Platt JA, Vail MM, Ehrlich Y, Spolnik KJ, Gregory RL. Bioactive nanofibrous scaffolds for regenerative endodontics. J Dent Res. 2013; 92(11): 963-9.
• Palasuk J, Kamocki K, Hippenmeyer L, Platt JA, Spolnik KJ, Gregory RL, Bottino MC. Bimix antimicrobial scaffolds for regenerative endodontics. J Endod. 2014; 40(11): 1879-84.
• Albuquerque MT, Valera MC, Moreira CS, Bresciani E, de Melo RM, Bottino MC. Effects of ciprofloxacin-containing scaffolds on enterococcus faecalis biofilms. J Endod. 2015; 41(5): 710-4.
• Albuquerque MT, Evans JD, Gregory RL, Valera MC, Bottino MC. Antibacterial TAP-mimic electrospun polymer scaffold: effects on P. gingivalis-infected dentin biofilm. Clin Oral Investig. 2016; 20(2): 387-93.
• Albuquerque MT, Ryan SJ, Münchow EA, Kamocka MM, Gregory RL, Valera MC, Bottino MC. Antimicrobial Effects of Novel Triple Antibiotic Paste-Mimic Scaffolds on Actinomyces naeslundii Biofilm. J Endod. 2015; 41(8): 1337-43.