Ozonun Oral Cerrahide Kullanımı
Year 2020,
Volume: 11 Issue: 1, 112 - 119, 03.03.2020
Ferhat Ayrancı
,
Mehmet Melih Ömezli
,
Damla Torul
Kadircan Kahveci
,
Hasan Akpınar
Abstract
Oksijenin
triatomik ve kararsız bir formu olan ozon tıp ve diş hekimliği alanlarında alternatif
veya tamamlayıcı tedavide uzun zamandır kullanılmaktadır. Günümüzde non-invaziv
ve düşük maliyetli bir tedavi seçeneği olan ozon terapisi ozon gazının antimikrobiyal,
antihipoksik, immunstimülatif, biyosentetik, hemostazı destekler, ayrıca analjezik
etkileri nedeniyle oral cerrahide kullanımı giderek yaygınlaşmaktadır. Bu
derlemenin amacı ozonun özellikleri, etki mekanizması ve tıp, diş hekimliği ve
özellikle oral cerrahideki kullanımını literatür ışığında değerlendirmektir.
References
- 1. Boztaş G, Ömürlü H. Restoratif diş hekimliğinde ozon tedavileri. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2014; 24(3).
- 2. Özler M, Öter Ş, Korkmaz A. Ozon Gazının Tıbbi Amaçlı Kullanılması. TAF Preventive Medicine Bulletin. 2009; 8(1).
- 3. Eroglu ZT, Kurtis B, Altug HA, Sahin S, Tuter G, Baris E. Effect of topical ozonetherapy on gingival wound healing in pigs: histological and immuno-histochemical analysis. Journal of Applied Oral Science. 2019; 27.
- 4. Seidler V, Linetskiy I, Hubálková H, Stankova H, Smucler R, Mazánek J. Ozone and its usage in general medicine and dentistry. A review article. Prague Med Rep. 2008; 109(1): 5-13.
- 5. Pietrocola G, Ceci M, Preda F, Poggio C, Colombo M. Evaluation of the antibacterial activity of a new ozonized olive oil against oral and periodontal pathogens. Journal of clinical and experimental dentistry. 2018; 10(11): e1103.
- 6. Seydanur Dengizek E, Serkan D, Abubekir E, Aysun Bay K, Onder O, Arife C. Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial. Journal of applied oral science : revista FOB. 2019; 27: e20180108.
- 7. Arita M, Nagayoshi M, Fukuizumi T, Okinaga T, Masumi S, Morikawa M, et al. Microbicidal efficacy of ozonated water against Candida albicans adhering to acrylic denture plates. Oral microbiology and immunology. 2005; 20(4): 206-10.
- 8. Isler SC, Unsal B, Soysal F, Ozcan G, Peker E, Karaca IR. The effects of ozone therapy as an adjunct to the surgical treatment of peri-implantitis. Journal of periodontal & implant science. 2018; 48(3): 136-51.
- 9. El Hadary AA, Yassin HH, Mekhemer ST, Holmes JC, Grootveld M. Evaluation of the effect of ozonated plant oils on the quality of osseointegration of dental implants under the influence of cyclosporin a: an in vivo study. Journal of Oral Implantology. 2011; 37(2): 247-57.
- 10. Braslavsky SE, Rubin MB. The history of ozone. Part VIII. Photochemical formation of ozone. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2011; 10(10): 1515-20.
- 11. Celakil T, Muric A, Gokcen Roehlig B, Evlioglu G, Keskin H. Effect of high‐frequency bio‐oxidative ozone therapy for masticatory muscle pain: a double‐blind randomised clinical trial. Journal of oral rehabilitation. 2017; 44(6): 442-51.
- 12. Azarpazhooh A, Limeback H. The application of ozone in dentistry: a systematic review of literature. Journal of dentistry. 2008; 36(2): 104-16.
- 13. Al-Omiri MK, Alhijawi M, AlZarea BK, Ra’ed S, Lynch E. Ozone treatment of recurrent aphthous stomatitis: a double blinded study. Scientific reports. 2016; 6: 27772.
- 14. Celakil T, Muric A, Gökcen Roehlig B, Evlioglu G. Management of pain in Tmd patients: Bio-oxidative ozone therapy versus occlusal splints. CRANIO®. 2019; 37(2): 85-93.
- 15. Mostafa B, Zakaria M. Evaluation of Combined Topical Ozone and Steroid Therapy in Management of Oral Lichen Planus. Open Access Maced J Med Sci. 2018; 6(5): 879-84.
- 16. Mohammadi Z, Shalavi S, Soltani MK, Asgary S. A review of the properties and applications of ozone in endodontics: an update. Iranian endodontic journal. 2013; 8(2): 40.
- 17. Sivalingam VP, Panneerselvam E, Raja KV, Gopi G. Does topical ozone therapy improve patient comfort after surgical removal of impacted mandibular third molar? A randomized controlled trial. Journal of Oral and Maxillofacial Surgery. 2017; 75(1): 51. e1-. e9.
- 18. Reddy S, Reddy N, Dinapadu S, Reddy M, Pasari S. Role of ozone therapy in minimal intervention dentistry and endodontics-a review. Journal of international oral health: JIOH. 2013; 5(3): 102.
- 19. Batinjan G, Zore IF, Vuletić M, Rupić I. The use of ozone in the prevention of osteoradionecrosis of the jaw. Saudi medical journal. 2014; 35(10): 1260.
- 20. Alan H, Vardi N, Özgür C, Hüseyin A, Yolcu Ü, Dogan DO. Comparison of the effects of low-level laser therapy and ozone therapy on bone healing. Journal of Craniofacial Surgery. 2015; 26(5): e396-e400.
- 21. Ozdemir H, Toker H, Balcı H, Ozer H. Effect of ozone therapy on autogenous bone graft healing in calvarial defects: a histologic and histometric study in rats. Journal of periodontal research. 2013; 48(6): 722-6.
- 22. Polydorou O, Halili A, Wittmer A, Pelz K, Hahn P. The antibacterial effect of gas ozone after 2 months of in vitro evaluation. Clinical oral investigations. 2012; 16(2): 545-50.
- 23. McKenna DF, Borzabadi-Farahani A, Lynch E. The effect of subgingival ozone and/or hydrogen peroxide on the development of peri-implant mucositis: a double-blind randomized controlled trial. The International journal of oral & maxillofacial implants. 2013; 28(6): 1483-9.
- 24. Hikal W, Basma Z, Sabry H. Evaluation of ozone application in dental unit water lines contaminated with pathogenic acanthamoeba. Iranian journal of parasitology. 2015; 10(3): 410.
- 25. Kazancioglu H, Kurklu E, Ezirganli S. Effects of ozone therapy on pain, swelling, and trismus following third molar surgery. International journal of oral and maxillofacial surgery. 2014; 43(5): 644-8.
- 26. Kim K, Brar P, Jakubowski J, Kaltman S, Lopez E. The use of corticosteroids and nonsteroidal antiinflammatory medication for the management of pain and inflammation after third molar surgery: a review of the literature. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2009; 107(5): 630-40.
- 27. Çebi AT. Diş çekimi sonrasi gözlenen alveolit vakalarinin değerlendirilmesi evaluation of alveolitis cases observed after tooth extraction. ile. 2016; 6: 6.
- 28. Rozanis J, Schofield I, Warren B. Is dry socket preventable? Dental journal. 1977; 43(5): 233.
- 29. Ahmedi J, Ahmedi E, Sejfija O, Agani Z, Hamiti V. Efficiency of gaseous ozone in reducing the development of dry socket following surgical third molar extraction. European journal of dentistry. 2016; 10(3): 381.
- 30. Oh KC, Cha JK, Kim CS, Choi SH, Chai JK, Jung UW. The influence of perforating the autogenous block bone and the recipient bed in dogs. Part I: a radiographic analysis. Clinical oral implants research. 2011; 22(11): 1298-302.
- 31. Nagata MJ, Santinoni CS, Pola NM, De Campos N, Messora MR, Bomfim SR, et al. Bone marrow aspirate combined with low-level laser therapy: a new therapeutic approach to enhance bone healing. Journal of Photochemistry and Photobiology B: Biology. 2013; 121: 6-14.
- 32. Kazancioglu HO, Ezirganli S, Aydin MS. Effects of laser and ozone therapies on bone healing in the calvarial defects. Journal of Craniofacial Surgery. 2013; 24(6): 2141-6.
- 33. Erdemci F, Gunaydin Y, Sencimen M, Bassorgun I, Ozler M, Oter S, et al. Histomorphometric evaluation of the effect of systemic and topical ozone on alveolar bone healing following tooth extraction in rats. International journal of oral and maxillofacial surgery. 2014; 43(6): 777-83.
- 34. Huth KC, Jakob FM, Saugel B, Cappello C, Paschos E, Hollweck R, et al. Effect of ozone on oral cells compared with established antimicrobials. European journal of oral sciences. 2006; 114(5): 435-40.
- 35. Thomas GW, Rael LT, Bar-Or R, Shimonkevitz R, Mains CW, Slone DS, et al. Mechanisms of delayed wound healing by commonly used antiseptics. Journal of Trauma and Acute Care Surgery. 2009; 66(1): 82-91.
- 36. Frascino AV, Mantesso A, Corrêa L, Deboni MCZ. Aqueous-ozone irrigation of bone monocortical wounds in hyperglycemic rats. Acta cirurgica brasileira. 2013;28(5): 327-33.
- 37. Renton T. Prevention of iatrogenic inferior alveolar nerve injuries in relation to dental procedures. Dental update. 2010; 37(6): 350-63.
- 38. Sirin Y, Soley S. Bilateral sagittal split osteotomi ve distraksiyon osteogenezi yontemleri ile yapilan alt cenenin ilerletilmesi girisimlerinde olusan inferior alveolar sinir hasarlarinin incelenmesi. Istanbul Üniversitesi Dis Hekimligi Fakültesi Dergisi. 2012; 46(1): 71.
- 39. Yucesoy T, Kutuk N, Canpolat DG, Alkan A. Comparison of Ozone and Photo-Biomodulation Therapies on Mental Nerve Injury in Rats. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 2017; 75(11): 2323-32.
- 40. Meitner SW, Bowen WH, Haidaris CG. Oral and esophageal Candida albicans infection in hyposalivatory rats. Infect Immun. 1990; 58(7): 2228-36.
- 41. Amin LE. Biological assessment of ozone therapy on experimental oral candidiasis in immunosuppressed rats. Biochem Biophys Rep. 2018; 15: 57-60.
- 42. Jacobson AS, Buchbinder D, Hu K, Urken ML. Paradigm shifts in the management of osteoradionecrosis of the mandible. Oral oncology. 2010; 46(11): 795-801.
- 43. Lyons A, Ghazali N. Osteoradionecrosis of the jaws: current understanding of its pathophysiology and treatment. The British journal of oral & maxillofacial surgery. 2008; 46(8): 653-60.
- 44. Öztürk Dn, Karaca Ir. Çenelerde görülen osteomiyelit. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi.2016; 164-9.
- 45. Van den Wyngaert T. Osteonecrosis of the jaw (ONJ) might explain the increased oral surgery risk in cancer patients treated with bisphosphonates. The journal of evidence-based dental practice. 2007; 7(3): 132-5.
- 46. Ripamonti CI, Maniezzo M, Boldini S, Pessi MA, Mariani L, Cislaghi E. Efficacy and tolerability of medical ozone gas insufflations in patients with osteonecrosis of the jaw treated with bisphosphonates-Preliminary data: Medical ozone gas insufflation in treating Onj lesions. Journal of bone oncology. 2012; 1(3): 81-7.
- 47. Agrillo A, Sassano P, Rinna C, Priore P, Iannetti G. Ozone therapy in extractive surgery on patients treated with bisphosphonates. The Journal of craniofacial surgery. 2007; 18(5): 1068-70.
- 48. Silva GB, Sacono NT, Othon-Leite AF, Mendonca EF, Arantes AM, Bariani C, et al. Effect of low-level laser therapy on inflammatory mediator release during chemotherapy-induced oral mucositis: a randomized preliminary study. Lasers in medical science. 2015; 30(1): 117-26.
- 49. Bayer S, Kazancioglu HO, Acar AH, Demirtas N, Kandas NO. Comparison of laser and ozone treatments on oral mucositis in an experimental model. Lasers in medical science. 2017; 32(3): 673-7.
- 50. Scully C, Porter S. Oral mucosal disease: recurrent aphthous stomatitis. The British journal of oral & maxillofacial surgery. 2008; 46(3): 198-206.
- 51. Geckili O, Bektas-Kayhan K, Eren P, Bilgin T, Unur M. The efficacy of a topical gel with triester glycerol oxide in denture-related mucosal injuries. Gerodontology. 2012; 29(2): e715-20.
- 52. AlZarea BK. Management of denture-related traumatic ulcers using ozone. The Journal of prosthetic dentistry. 2019; 121(1): 76-82.
- 53. Kazancioglu HO, Erisen M. Comparison of Low-Level Laser Therapy versus Ozone Therapy in the Treatment of Oral Lichen Planus. Annals of dermatology. 2015; 27(5): 485-91.
- 54. Scully C, Carrozzo M. Oral mucosal disease: Lichen planus. British Journal of Oral and Maxillofacial Surgery. 2008; 46(1): 15-21.
- 55. Schwarz F, Hegewald A, John G, Sahm N, Becker J. Four-year follow-up of combined surgical therapy of advanced peri-implantitis evaluating two methods of surface decontamination. Journal of clinical periodontology. 2013; 40(10): 962-7.
- 56. Garcia-Morales JM, Tortamano-Neto P, Todescan FF, de Andrade JC, Jr., Marotti J, Zezell DM. Stability of dental implants after irradiation with an 830-nm low-level laser: a double-blind randomized clinical study. Lasers in medical science. 2012; 27(4): 703-11.
- 57. Karaca IR, Ergun G, Ozturk DN. Is Low-level laser therapy and gaseous ozone application effective on osseointegration of immediately loaded implants? Niger J Clin Pract. 2018; 21(6): 703-10.
- 58. Alkan Ö, Çöven BO, Özçopur B, Kazancı F, Kaya Y, Aydoğan C, et al. Effects of Ozone and Prophylactic Antimicrobial Applications on Shear Bond Strength of Orthodontic Brackets. Turkish journal of orthodontics. 2017; 30(4): 101.
- 59. Jose P, Ramabhadran BK, Emmatty R, Paul TP. Assessment of the effect of ozonated water irrigation on gingival inflammation in patients undergoing fixed orthodontic treatment. Journal of Indian Society of Periodontology. 2017; 21(6):484.
Year 2020,
Volume: 11 Issue: 1, 112 - 119, 03.03.2020
Ferhat Ayrancı
,
Mehmet Melih Ömezli
,
Damla Torul
Kadircan Kahveci
,
Hasan Akpınar
References
- 1. Boztaş G, Ömürlü H. Restoratif diş hekimliğinde ozon tedavileri. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2014; 24(3).
- 2. Özler M, Öter Ş, Korkmaz A. Ozon Gazının Tıbbi Amaçlı Kullanılması. TAF Preventive Medicine Bulletin. 2009; 8(1).
- 3. Eroglu ZT, Kurtis B, Altug HA, Sahin S, Tuter G, Baris E. Effect of topical ozonetherapy on gingival wound healing in pigs: histological and immuno-histochemical analysis. Journal of Applied Oral Science. 2019; 27.
- 4. Seidler V, Linetskiy I, Hubálková H, Stankova H, Smucler R, Mazánek J. Ozone and its usage in general medicine and dentistry. A review article. Prague Med Rep. 2008; 109(1): 5-13.
- 5. Pietrocola G, Ceci M, Preda F, Poggio C, Colombo M. Evaluation of the antibacterial activity of a new ozonized olive oil against oral and periodontal pathogens. Journal of clinical and experimental dentistry. 2018; 10(11): e1103.
- 6. Seydanur Dengizek E, Serkan D, Abubekir E, Aysun Bay K, Onder O, Arife C. Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial. Journal of applied oral science : revista FOB. 2019; 27: e20180108.
- 7. Arita M, Nagayoshi M, Fukuizumi T, Okinaga T, Masumi S, Morikawa M, et al. Microbicidal efficacy of ozonated water against Candida albicans adhering to acrylic denture plates. Oral microbiology and immunology. 2005; 20(4): 206-10.
- 8. Isler SC, Unsal B, Soysal F, Ozcan G, Peker E, Karaca IR. The effects of ozone therapy as an adjunct to the surgical treatment of peri-implantitis. Journal of periodontal & implant science. 2018; 48(3): 136-51.
- 9. El Hadary AA, Yassin HH, Mekhemer ST, Holmes JC, Grootveld M. Evaluation of the effect of ozonated plant oils on the quality of osseointegration of dental implants under the influence of cyclosporin a: an in vivo study. Journal of Oral Implantology. 2011; 37(2): 247-57.
- 10. Braslavsky SE, Rubin MB. The history of ozone. Part VIII. Photochemical formation of ozone. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2011; 10(10): 1515-20.
- 11. Celakil T, Muric A, Gokcen Roehlig B, Evlioglu G, Keskin H. Effect of high‐frequency bio‐oxidative ozone therapy for masticatory muscle pain: a double‐blind randomised clinical trial. Journal of oral rehabilitation. 2017; 44(6): 442-51.
- 12. Azarpazhooh A, Limeback H. The application of ozone in dentistry: a systematic review of literature. Journal of dentistry. 2008; 36(2): 104-16.
- 13. Al-Omiri MK, Alhijawi M, AlZarea BK, Ra’ed S, Lynch E. Ozone treatment of recurrent aphthous stomatitis: a double blinded study. Scientific reports. 2016; 6: 27772.
- 14. Celakil T, Muric A, Gökcen Roehlig B, Evlioglu G. Management of pain in Tmd patients: Bio-oxidative ozone therapy versus occlusal splints. CRANIO®. 2019; 37(2): 85-93.
- 15. Mostafa B, Zakaria M. Evaluation of Combined Topical Ozone and Steroid Therapy in Management of Oral Lichen Planus. Open Access Maced J Med Sci. 2018; 6(5): 879-84.
- 16. Mohammadi Z, Shalavi S, Soltani MK, Asgary S. A review of the properties and applications of ozone in endodontics: an update. Iranian endodontic journal. 2013; 8(2): 40.
- 17. Sivalingam VP, Panneerselvam E, Raja KV, Gopi G. Does topical ozone therapy improve patient comfort after surgical removal of impacted mandibular third molar? A randomized controlled trial. Journal of Oral and Maxillofacial Surgery. 2017; 75(1): 51. e1-. e9.
- 18. Reddy S, Reddy N, Dinapadu S, Reddy M, Pasari S. Role of ozone therapy in minimal intervention dentistry and endodontics-a review. Journal of international oral health: JIOH. 2013; 5(3): 102.
- 19. Batinjan G, Zore IF, Vuletić M, Rupić I. The use of ozone in the prevention of osteoradionecrosis of the jaw. Saudi medical journal. 2014; 35(10): 1260.
- 20. Alan H, Vardi N, Özgür C, Hüseyin A, Yolcu Ü, Dogan DO. Comparison of the effects of low-level laser therapy and ozone therapy on bone healing. Journal of Craniofacial Surgery. 2015; 26(5): e396-e400.
- 21. Ozdemir H, Toker H, Balcı H, Ozer H. Effect of ozone therapy on autogenous bone graft healing in calvarial defects: a histologic and histometric study in rats. Journal of periodontal research. 2013; 48(6): 722-6.
- 22. Polydorou O, Halili A, Wittmer A, Pelz K, Hahn P. The antibacterial effect of gas ozone after 2 months of in vitro evaluation. Clinical oral investigations. 2012; 16(2): 545-50.
- 23. McKenna DF, Borzabadi-Farahani A, Lynch E. The effect of subgingival ozone and/or hydrogen peroxide on the development of peri-implant mucositis: a double-blind randomized controlled trial. The International journal of oral & maxillofacial implants. 2013; 28(6): 1483-9.
- 24. Hikal W, Basma Z, Sabry H. Evaluation of ozone application in dental unit water lines contaminated with pathogenic acanthamoeba. Iranian journal of parasitology. 2015; 10(3): 410.
- 25. Kazancioglu H, Kurklu E, Ezirganli S. Effects of ozone therapy on pain, swelling, and trismus following third molar surgery. International journal of oral and maxillofacial surgery. 2014; 43(5): 644-8.
- 26. Kim K, Brar P, Jakubowski J, Kaltman S, Lopez E. The use of corticosteroids and nonsteroidal antiinflammatory medication for the management of pain and inflammation after third molar surgery: a review of the literature. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2009; 107(5): 630-40.
- 27. Çebi AT. Diş çekimi sonrasi gözlenen alveolit vakalarinin değerlendirilmesi evaluation of alveolitis cases observed after tooth extraction. ile. 2016; 6: 6.
- 28. Rozanis J, Schofield I, Warren B. Is dry socket preventable? Dental journal. 1977; 43(5): 233.
- 29. Ahmedi J, Ahmedi E, Sejfija O, Agani Z, Hamiti V. Efficiency of gaseous ozone in reducing the development of dry socket following surgical third molar extraction. European journal of dentistry. 2016; 10(3): 381.
- 30. Oh KC, Cha JK, Kim CS, Choi SH, Chai JK, Jung UW. The influence of perforating the autogenous block bone and the recipient bed in dogs. Part I: a radiographic analysis. Clinical oral implants research. 2011; 22(11): 1298-302.
- 31. Nagata MJ, Santinoni CS, Pola NM, De Campos N, Messora MR, Bomfim SR, et al. Bone marrow aspirate combined with low-level laser therapy: a new therapeutic approach to enhance bone healing. Journal of Photochemistry and Photobiology B: Biology. 2013; 121: 6-14.
- 32. Kazancioglu HO, Ezirganli S, Aydin MS. Effects of laser and ozone therapies on bone healing in the calvarial defects. Journal of Craniofacial Surgery. 2013; 24(6): 2141-6.
- 33. Erdemci F, Gunaydin Y, Sencimen M, Bassorgun I, Ozler M, Oter S, et al. Histomorphometric evaluation of the effect of systemic and topical ozone on alveolar bone healing following tooth extraction in rats. International journal of oral and maxillofacial surgery. 2014; 43(6): 777-83.
- 34. Huth KC, Jakob FM, Saugel B, Cappello C, Paschos E, Hollweck R, et al. Effect of ozone on oral cells compared with established antimicrobials. European journal of oral sciences. 2006; 114(5): 435-40.
- 35. Thomas GW, Rael LT, Bar-Or R, Shimonkevitz R, Mains CW, Slone DS, et al. Mechanisms of delayed wound healing by commonly used antiseptics. Journal of Trauma and Acute Care Surgery. 2009; 66(1): 82-91.
- 36. Frascino AV, Mantesso A, Corrêa L, Deboni MCZ. Aqueous-ozone irrigation of bone monocortical wounds in hyperglycemic rats. Acta cirurgica brasileira. 2013;28(5): 327-33.
- 37. Renton T. Prevention of iatrogenic inferior alveolar nerve injuries in relation to dental procedures. Dental update. 2010; 37(6): 350-63.
- 38. Sirin Y, Soley S. Bilateral sagittal split osteotomi ve distraksiyon osteogenezi yontemleri ile yapilan alt cenenin ilerletilmesi girisimlerinde olusan inferior alveolar sinir hasarlarinin incelenmesi. Istanbul Üniversitesi Dis Hekimligi Fakültesi Dergisi. 2012; 46(1): 71.
- 39. Yucesoy T, Kutuk N, Canpolat DG, Alkan A. Comparison of Ozone and Photo-Biomodulation Therapies on Mental Nerve Injury in Rats. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 2017; 75(11): 2323-32.
- 40. Meitner SW, Bowen WH, Haidaris CG. Oral and esophageal Candida albicans infection in hyposalivatory rats. Infect Immun. 1990; 58(7): 2228-36.
- 41. Amin LE. Biological assessment of ozone therapy on experimental oral candidiasis in immunosuppressed rats. Biochem Biophys Rep. 2018; 15: 57-60.
- 42. Jacobson AS, Buchbinder D, Hu K, Urken ML. Paradigm shifts in the management of osteoradionecrosis of the mandible. Oral oncology. 2010; 46(11): 795-801.
- 43. Lyons A, Ghazali N. Osteoradionecrosis of the jaws: current understanding of its pathophysiology and treatment. The British journal of oral & maxillofacial surgery. 2008; 46(8): 653-60.
- 44. Öztürk Dn, Karaca Ir. Çenelerde görülen osteomiyelit. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi.2016; 164-9.
- 45. Van den Wyngaert T. Osteonecrosis of the jaw (ONJ) might explain the increased oral surgery risk in cancer patients treated with bisphosphonates. The journal of evidence-based dental practice. 2007; 7(3): 132-5.
- 46. Ripamonti CI, Maniezzo M, Boldini S, Pessi MA, Mariani L, Cislaghi E. Efficacy and tolerability of medical ozone gas insufflations in patients with osteonecrosis of the jaw treated with bisphosphonates-Preliminary data: Medical ozone gas insufflation in treating Onj lesions. Journal of bone oncology. 2012; 1(3): 81-7.
- 47. Agrillo A, Sassano P, Rinna C, Priore P, Iannetti G. Ozone therapy in extractive surgery on patients treated with bisphosphonates. The Journal of craniofacial surgery. 2007; 18(5): 1068-70.
- 48. Silva GB, Sacono NT, Othon-Leite AF, Mendonca EF, Arantes AM, Bariani C, et al. Effect of low-level laser therapy on inflammatory mediator release during chemotherapy-induced oral mucositis: a randomized preliminary study. Lasers in medical science. 2015; 30(1): 117-26.
- 49. Bayer S, Kazancioglu HO, Acar AH, Demirtas N, Kandas NO. Comparison of laser and ozone treatments on oral mucositis in an experimental model. Lasers in medical science. 2017; 32(3): 673-7.
- 50. Scully C, Porter S. Oral mucosal disease: recurrent aphthous stomatitis. The British journal of oral & maxillofacial surgery. 2008; 46(3): 198-206.
- 51. Geckili O, Bektas-Kayhan K, Eren P, Bilgin T, Unur M. The efficacy of a topical gel with triester glycerol oxide in denture-related mucosal injuries. Gerodontology. 2012; 29(2): e715-20.
- 52. AlZarea BK. Management of denture-related traumatic ulcers using ozone. The Journal of prosthetic dentistry. 2019; 121(1): 76-82.
- 53. Kazancioglu HO, Erisen M. Comparison of Low-Level Laser Therapy versus Ozone Therapy in the Treatment of Oral Lichen Planus. Annals of dermatology. 2015; 27(5): 485-91.
- 54. Scully C, Carrozzo M. Oral mucosal disease: Lichen planus. British Journal of Oral and Maxillofacial Surgery. 2008; 46(1): 15-21.
- 55. Schwarz F, Hegewald A, John G, Sahm N, Becker J. Four-year follow-up of combined surgical therapy of advanced peri-implantitis evaluating two methods of surface decontamination. Journal of clinical periodontology. 2013; 40(10): 962-7.
- 56. Garcia-Morales JM, Tortamano-Neto P, Todescan FF, de Andrade JC, Jr., Marotti J, Zezell DM. Stability of dental implants after irradiation with an 830-nm low-level laser: a double-blind randomized clinical study. Lasers in medical science. 2012; 27(4): 703-11.
- 57. Karaca IR, Ergun G, Ozturk DN. Is Low-level laser therapy and gaseous ozone application effective on osseointegration of immediately loaded implants? Niger J Clin Pract. 2018; 21(6): 703-10.
- 58. Alkan Ö, Çöven BO, Özçopur B, Kazancı F, Kaya Y, Aydoğan C, et al. Effects of Ozone and Prophylactic Antimicrobial Applications on Shear Bond Strength of Orthodontic Brackets. Turkish journal of orthodontics. 2017; 30(4): 101.
- 59. Jose P, Ramabhadran BK, Emmatty R, Paul TP. Assessment of the effect of ozonated water irrigation on gingival inflammation in patients undergoing fixed orthodontic treatment. Journal of Indian Society of Periodontology. 2017; 21(6):484.