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Koroner arter anevrizmalı hastaların anjiyografik ve klinik özellikleri: 52 hastanın retrospektif incelenmesi ve literatürün gözden geçirilmesi

Year 2008, Volume: 15 Issue: 4, 1 - 5, 29.05.2009

Abstract

Süleyman Demirel Üniversitesi
TIP FAKÜLTESİ DERGİSİ: 2008 Aralık; 15 (4)

Koroner arter anevrizmalı hastaların anjiyografik ve klinik özellikleri: 52 hastanın retrospektif incelenmesi ve literatürün gözden geçirilmesi

Gürkan Acar*, Özkan Dede**, Yasin Türker**, Selahaddin Akçay**, Ahmet Altınbaş**


Özet
Amaç: Koroner arter anevrizması, koroner arter hastalığının nadir rastlanan bir türüdür. Koroner anevrizmalı hastaların klinik özellikleri ve uzun dönem prognozlarına dair literatür bilgisi azdır. Bu çalışmada; koroner arter anevrizmalı hastaların sıklığı, klinik ve anjiyografik özelliklerini incelemeyi amaçladık. Gereç ve Yöntem: Kliniğimizde Ocak 2000 ile Kasım 2004 tarihleri arasında anjiyografik olarak koroner arter anevrizması tespit edilen 52 hastanın klinik özellikleri ve anjiyogramları incelendi. Bulgular: Koroner anjiyografi yapılan 6842 hastanın 52.sinde (%0.76) koroner arter anevrizması vardı 39 erkek (%75), 13 kadýn (%25). Koroner arter anevrizması en sık sol ön inen arterde (n=22, %42) tespit edildi. Hipertansiyon (n=32, %61) en sık görülen aterosklerotik risk faktörüydü. Koroner arter anevrizmasına eşlik eden tıkayıcı koroner arter hastalığına 34 hastada (%65) rastlandı. Sonuç: Çalışmamızda koroner arter anevrizması sıklığı %0.76 idi. Koroner arter Anevrizmasına en sık sol ön inen arterde rastlanmış olup bu hastalarda hipertansiyon en sık karşılaşılan risk faktörüdür. Koroner arter anevrizması ile tıkayıcı koroner arter hastalığı birlikteliğine sık rastlanmaktadır. Anahtar Sözcükler: Koroner arter anevrizması, ateroskleroz risk faktörleri, anjiyografi

Abstract

Angiographic and clinical characteristics of patients with coronary artery aneurysm:
A retrospective analysis of 54 patients and review of the literature Aim: Coronary artery aneurysm (CAA) is a rare type of coronary artery disease. There is a lack of literature
data about the clinical characteristics and long term prognosis of patients with CAA. In this study; we aimed to investigate frequency, angiographic and clinical characteristics of patients with CAA. Methods: Clinical characteristics and coronary angiograms of 52 patients who were diagnosed as having CAA between January 2000 and November 2004 were investigated. Results: Total 6842 patients underwent coronary angiography and fifty two of them 39 male (75%), 13 female (25%) were diagnosed as having CAA (%0.76). CAA was mostly seen in left anterior descending artery (n=22, %42). Hypertension was the most frequent therosclerotic risk factor (n=32, 61%). Stenotic coronary artery disease accompanying to the CAA was present in 34 (65%) patients. Conclusions: In our study, frequency of CAA was % 0.76. Hypertension was the most frequent risk factor and left anterior descending was the most common site of aneurysm. Furthermore, presence of stenotic coronary artery disease with CAA was common.

Key words: Coronary artery aneurysm, atherosclerosis risk factors, angiography

References

  • Falsetti HL, Carrol RJ. Coronary artery aneurysm. Chest 1976;69:630-6.
  • Befeler B, Aranda MJ, Embi A, Mullin FL, El-Sherif N, Lazzara R. Coronary artery aneurysms: study of the etiology, clinical cource and effect on left ventricular function and prognosis. Am J Med 1977;62:597-607.
  • Swaye PS, Fisher LD, Litwin P, Vignola PA, Judkins MP, Kemp HG, et al. Aneurysmal coronary artery disease. Circulation 1983;67:134-8.
  • Hartnell GG, Parnell BM, Pridie RB. Coronary artery ectasia. Its prevalence and clinical significance in 4993 patient. Br Heart J 1985;54:392-5.
  • Markis JE, Joffe CD, Cohn PF, Feen DJ, Herman MV, Gorlin R. Clinical significance of coronary arterial ectasia. Am J Cardiol 1976;37:217-22.
  • Wang KY, Ting CT, St John Sutton M, Chen YT. Coronary artery aneurysms: A 25-patient study. Cathet Cardiovasc Intervent 1999;48:31-8.
  • Syed M, Lesch M. Coronary artery aneurysm: a review. Prog Cardiovasc Dis 1997;40:77-84.
  • Kruger D, Stierle U, Herrmann G, Simon R, Sheikhzadeh A. Exercise-induced myocardial ischemia in isolated coronary artery ectasias and aneurysms (“dilated coronopathy”). J Am Coll Cardiol 1999;34:1461-70.
  • Harikrishnan S, Sunder KR, Tharakan JM, Titus T, Bhat A, Sivasankaran S, et al. Saccular coronary aneurysms: Angiographic and clinical profile and follow-up of 22 patients. Indian Heart J 2000;52:178- 82.
  • Swanton RH, Thomas ML, Coltart DJ, Jenkins BS, Webb-Peploe MM, Williams BT. Coronary artery ectasia-- a variant of occlusive arteriosclerosis. Br Heart J 1978;40:393-400.
  • Baman TS, Cole JH, Devireddy CM, Sperling LS. Risc factors and outcomes in patients with coronary artery aneurysms. Am J Cardiol 2004;93:1549-51.
  • Altinbas A, Nazli C, Kinay O, Ergene O, Gedikli O, Ozaydin M, et al. Predictors of exercise induced myocardial ischemia in patients with isolated coronary artery ectasia. Int J Cardiovasc Imaging 2004;20:3-17.
  • Robinson FC. Aneurysm of the coronary arteries. Am Heart J 1985;109:129-35.
  • Sorrell VL, Davis MJ, Bove AA. Current knowledge and significance of coronary artery ectasia: a chronologic review of the literature, recommendations for treatment, possible etiologies, and future considerations. Clin Cardiol 1998;21:157-60.
  • Dralle JG, Turner C, Hsu J, Replogle RL. Coronary artery aneurysm after angioplasty and atherectomy. Ann Thorac Surg 1995;59:1030-5.
  • Tengiz I, Ercan E, Aliyev E, Sekuri C, Duman C, Altuglu I. Elevated levels of matrix metalloprotein-3 in patients with coronary aneurysm: A case control study. Curr Control Trials Cardiovasc Med 2004;13:10.
  • Kajinami K, Kasahima S, Oda Y, Koizumi J, Kadsuda S, Mabuchi H. Coronary ectasia in familial hypercholesterolemia: histopathologic study regarding matrix metalloproteinases. Mod Pathol 1999;12:1174- 80.
  • Selke KG, Vemulapalli P, Brodarick SA, Coordes C, Gowda S, Salem B, et al. Giant coronary artery aneurysm: detection with echocardiography, computed tomography, and magnetic resonance imaging. Am Heart J 1991;121:1544-7.
  • Berkalp B, Kervancioglu C, Oral D. Coronary artery aneurysm formation after balloon angioplasty and stent implantation. Int J Cardiol 1999;69:65-70.
  • Tunick PA, Slater J, Kronzon I, Glassman E.
  • Discrete atherosclerotic coronary artery aneurysm: a study of 20 patients. J Am Coll Cardiol 1990;15:279-82.
  • Sayýn T, Doven O, Berkalp B, Akyurek O, Guleç S, Oral D. Exercise-induced myocardial ischemia in patients with coronary artery ectasia without obstructive coronary artery disease. Int J Cardiol 2001;78:143-9.
  • Gunduz H, Akdemir R, Binak E, Tamer A, Uyan C. Spontaneous rupture of a coronary artery aneurysm. Jpn Heart J 2004;45:331-6.
  • Stajduhar KC, Laird JR, Rogan KM, Wortham DC. Coronary arterial ectasia; Increased prevalence in patients with abdominal aortic aneurysm as compared to occlusive atherosclerotic peripheral vascular disease. Am Heart J 1993;125:86-92.
Year 2008, Volume: 15 Issue: 4, 1 - 5, 29.05.2009

Abstract

References

  • Falsetti HL, Carrol RJ. Coronary artery aneurysm. Chest 1976;69:630-6.
  • Befeler B, Aranda MJ, Embi A, Mullin FL, El-Sherif N, Lazzara R. Coronary artery aneurysms: study of the etiology, clinical cource and effect on left ventricular function and prognosis. Am J Med 1977;62:597-607.
  • Swaye PS, Fisher LD, Litwin P, Vignola PA, Judkins MP, Kemp HG, et al. Aneurysmal coronary artery disease. Circulation 1983;67:134-8.
  • Hartnell GG, Parnell BM, Pridie RB. Coronary artery ectasia. Its prevalence and clinical significance in 4993 patient. Br Heart J 1985;54:392-5.
  • Markis JE, Joffe CD, Cohn PF, Feen DJ, Herman MV, Gorlin R. Clinical significance of coronary arterial ectasia. Am J Cardiol 1976;37:217-22.
  • Wang KY, Ting CT, St John Sutton M, Chen YT. Coronary artery aneurysms: A 25-patient study. Cathet Cardiovasc Intervent 1999;48:31-8.
  • Syed M, Lesch M. Coronary artery aneurysm: a review. Prog Cardiovasc Dis 1997;40:77-84.
  • Kruger D, Stierle U, Herrmann G, Simon R, Sheikhzadeh A. Exercise-induced myocardial ischemia in isolated coronary artery ectasias and aneurysms (“dilated coronopathy”). J Am Coll Cardiol 1999;34:1461-70.
  • Harikrishnan S, Sunder KR, Tharakan JM, Titus T, Bhat A, Sivasankaran S, et al. Saccular coronary aneurysms: Angiographic and clinical profile and follow-up of 22 patients. Indian Heart J 2000;52:178- 82.
  • Swanton RH, Thomas ML, Coltart DJ, Jenkins BS, Webb-Peploe MM, Williams BT. Coronary artery ectasia-- a variant of occlusive arteriosclerosis. Br Heart J 1978;40:393-400.
  • Baman TS, Cole JH, Devireddy CM, Sperling LS. Risc factors and outcomes in patients with coronary artery aneurysms. Am J Cardiol 2004;93:1549-51.
  • Altinbas A, Nazli C, Kinay O, Ergene O, Gedikli O, Ozaydin M, et al. Predictors of exercise induced myocardial ischemia in patients with isolated coronary artery ectasia. Int J Cardiovasc Imaging 2004;20:3-17.
  • Robinson FC. Aneurysm of the coronary arteries. Am Heart J 1985;109:129-35.
  • Sorrell VL, Davis MJ, Bove AA. Current knowledge and significance of coronary artery ectasia: a chronologic review of the literature, recommendations for treatment, possible etiologies, and future considerations. Clin Cardiol 1998;21:157-60.
  • Dralle JG, Turner C, Hsu J, Replogle RL. Coronary artery aneurysm after angioplasty and atherectomy. Ann Thorac Surg 1995;59:1030-5.
  • Tengiz I, Ercan E, Aliyev E, Sekuri C, Duman C, Altuglu I. Elevated levels of matrix metalloprotein-3 in patients with coronary aneurysm: A case control study. Curr Control Trials Cardiovasc Med 2004;13:10.
  • Kajinami K, Kasahima S, Oda Y, Koizumi J, Kadsuda S, Mabuchi H. Coronary ectasia in familial hypercholesterolemia: histopathologic study regarding matrix metalloproteinases. Mod Pathol 1999;12:1174- 80.
  • Selke KG, Vemulapalli P, Brodarick SA, Coordes C, Gowda S, Salem B, et al. Giant coronary artery aneurysm: detection with echocardiography, computed tomography, and magnetic resonance imaging. Am Heart J 1991;121:1544-7.
  • Berkalp B, Kervancioglu C, Oral D. Coronary artery aneurysm formation after balloon angioplasty and stent implantation. Int J Cardiol 1999;69:65-70.
  • Tunick PA, Slater J, Kronzon I, Glassman E.
  • Discrete atherosclerotic coronary artery aneurysm: a study of 20 patients. J Am Coll Cardiol 1990;15:279-82.
  • Sayýn T, Doven O, Berkalp B, Akyurek O, Guleç S, Oral D. Exercise-induced myocardial ischemia in patients with coronary artery ectasia without obstructive coronary artery disease. Int J Cardiol 2001;78:143-9.
  • Gunduz H, Akdemir R, Binak E, Tamer A, Uyan C. Spontaneous rupture of a coronary artery aneurysm. Jpn Heart J 2004;45:331-6.
  • Stajduhar KC, Laird JR, Rogan KM, Wortham DC. Coronary arterial ectasia; Increased prevalence in patients with abdominal aortic aneurysm as compared to occlusive atherosclerotic peripheral vascular disease. Am Heart J 1993;125:86-92.
There are 24 citations in total.

Details

Primary Language English
Journal Section Research Articles
Authors

Gürkan Acar

Özkan Dede This is me

Yasin Türker This is me

Selahaddin Akçay This is me

Ahmet Altınbaş This is me

Publication Date May 29, 2009
Submission Date May 28, 2009
Published in Issue Year 2008 Volume: 15 Issue: 4

Cite

Vancouver Acar G, Dede Ö, Türker Y, Akçay S, Altınbaş A. Koroner arter anevrizmalı hastaların anjiyografik ve klinik özellikleri: 52 hastanın retrospektif incelenmesi ve literatürün gözden geçirilmesi. Med J SDU. 2009;15(4):1-5.

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