İnmemiş Testisli Çocuklarda Hormon Tedavisi. Prospektif Klinik Çalışma.

Year 2010, Volume: 17 Issue: 1, 14 - 18, 30.03.2010

Kevser Gürsoy Mustafa Savaş , Selçuk Kaya , Ayhan Gürsoy Behçet Büyükyavuz İ. Özgüner

Abstract

AMAÇ: İnmemiş testisli çocuklarda hCG tedavisinin testis inişine ve hacmine, penis boyuna, serum antisperm antikor (ASA), folikül stimulan hormon (FSH), luteinizan hormon (LH) ve total testosteron düzeylerine olan etkisini araştırmak.
GEREÇ VE YÖNTEM: Etik kurul onayı sonrasında çalışmaya inmemiş testis tanısı almış 46 prepubertal olgu dahil edildi. Hastalar Plasebo (n=17) ve Pregnyl (n=29) olmak üzere iki gruba ayrıldı. Pregnyl grubundan 6 olguda (%20,6) hCG tedavisi sonrasında testis inişi oldu ve bu olgular çalışmadan çıkarıldı (n=23). Birinci gruptakilere (Plasebo) 3 hafta boyunca, haftada bir kez olmak üzere im SF uygulandı. İkinci gruptakiler (Pregnyl) 3 hafta boyunca, haftada bir kez olmak üzere 100 IU/kg im hCG ile tedavi edildiler. Olguların tedavi öncesinde ve orşiopeksiden 1 ay sonra ultrasonografi ile testis boyutları ve yerleşimleri değerlendirildi, penis boyları, serum ASA, FSH, LH ve total testosteron düzeyleri ölçüldü.
BULGULAR: Penis boyu, testis hacmi ve serum total testosteron düzeyi hCG tedavisi alan grupta (Pregnyl), SF tedavisi alan gruba (Plasebo) göre anlamlı düzeyde arttı (p<0,01). Serum ASA, FSH ve LH değerleri her iki grupta karşılaştırıldığında, istatistiksel olarak anlamlı farklılık saptanmadı.
SONUÇ: İnmemiş testisli çocuklarda hormon tedavisi testis inişini sağlayabilir ve cerrahi tedavi öncesinde bir seçenek olarak düşünülmelidir. İnfertilitede rolü olabilen serum ASA düzeyleri hormon tedavisinden etkilenmemiştir. Testis inişinin yanı sıra, bu bulgu da, inmemiş testisde hormon tedavisinin kullanımını desteklemektedir.

Keywords

Ýnmemiþ testis, hCG, antisperm antikor

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