ASTIMDA ANALJEZİK (NSAİİ) KULLANIMI

Year 2012, Volume: 19 Issue: 3, 111 - 119, 30.09.2012

Halil Aşcı , Fatma Cankara Mehmet Özer

Abstract

Astım; T lenfositler, eozinofiller ve mast hücreleri başta olmak üzere birçok hücre ve hücresel elementlerin rol oynadığı havayollarının kronik inflamatuvar bir hastalığıdır. Tedavisinde başlıca kortikosteroidler, beta agonistler, antikolinerjikler, kromonlar (mast hücresi stabilizatörleri), lökotrien antagonistleri ve teofilin kullanılmaktadır. Ancak bu ilaçlar başka endikasyonlar (ağrı, enfeksiyon gibi) sırasında kullanılan ilaçlarla etkileşerek astımı provake edebilir. Bu etkileşimler bazı ilaçlarda farmakokinetik düzeyde bazı ilaçlarda ise farmakodinamik düzeylerde olmaktadır. Bu derlemede nonsteroid antiinflamatuar ilaçlar ile astımlı hastalarda kullanılan ilaçlar arasındaki etkileşimden bahsedilecektir.

Keywords

Astým, analjezik, aspirin, bronkospazm

References

• Raissy HH, Harkins M, Marshýk PL. Drug-Induced Pulmonary Diseases. In: Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM. Pharmacotherapy, A Pathophysiologic Aprroach (7th Ed), The McGraw-Hill Companies Inc., New York, 2008;521-34.
• Astým taný ve tedavi rehberi. Toraks Dergisi, 2009;10:6- 15
• Kayaalp O. Rasyonel Tedavi Yönünden Týbbi Farmakoloji. 1. Cilt. 11. Baský. Ankara. Hacettepe-Taþ Yayýncýlýk 2005; 594-612
• Demir E, Midyat L. Astým Patogenezi. Turkiye Klinikleri J Pediatr Sci 2009;5(3):6-16.
• Sczeklik A, Stevenson DD. Aspirin induced asthma: advances in pathogenesis and management. J Allergy Clin Immunol 1999;104:5-13
• Szczeklik A. Aspirin-induced asthma: a tribute to John Vane as a source of inspiration. 2010;62(3):526-9
• Christie PE, Christie PE, Tagari P, Ford-Hutchinson AW, Charlesson S, Chee P, Arm JP al. Urinaryleukotriene E4 concentrations increase after aspirin challenge in aspirin sensitive asthmatic subjects. Am Rev Respir Dis 1991;143:1025-9.
• Arm JP, O'Hickey SP, Hawksworth RJ, Fong CY, Crea AE, Spur BW et all. Asthmatic airways have a dispropionate hyperresponsiveness to LTE4, as compared with normal airways, but not to LTC4, LTD4, methacholine and histamine. Am Rev Respir Dis 1990;142:1112-8.
• Pasaje CF, Kim JH, Park BL, Cheong HS, Kim MK, Choi IS et all. A possible association of EMID2 polymorphisms with aspirin hypersensitivity in asthma. Immunogenetics. 2011;63(1):13-21.
• Sahin U, Akkaya A, Unlu M, Turgut E, Uygun N. Isparta il merkezinde 15-18 yaþ gruplarýnda astým semptom prevalansýnýn araþtýrýlmasý. SDÜ Týp Fakültesi Dergisi 1997 4(3): 1-5.
• Sánchez-Borges M, Capriles-Hulett A. Atopy is a risk factor for nonsteroidal anti-inflammatory drug sensitivity. Ann Allergy Asthma Immunol 2000; 84:101-6.
• Bavbek S, Çelik G, Ediger D, Mungan D, Sin B, Demirel YS. Severity and associated risk factors in adult asthma patients in Turkey. Ann Allergy Asthma Immunol 2000;85:134-9.
• Stevenson DD. Adverse reactions to nonsteroidal antiinflammatuar drugs. Immunol and Allergy Clin North America 1998;18:773-97.
• Çelik G, Mungan D, Özer F, Ediger D, Bavbek S, Sin B et all. Clinical features and atop profile in Turkish subjects with analgesic intolerance. Asthma 2002; 39, 101-6.
• Sanchez-Borges M, Capriles-Hulett A, Fernandez- Caldas E, Suarez-Chacon R, Caballero F, Castillo S et al. Mite contaminated foods as a cause of anaphylaxis. J Alllergy Clin Immunol 1997; 99:738-43.
• Settipane GA. Aspirin and allergic diseases: A review. Am J Med 1983;74(6A):102–9.
• Mete N, Kokuludað A. Aspirin ve Nonsteroid Antiinflamatuar Duyarlýlýðý. Türkiye Klinikleri J Allergy-Asthma 2003;5:48-58.
• Stevenson DD. Anaphylactic and anaphylactoid reactions to aspirin and other nonsteroidal antiinflammatory drugs. Immunol Allergy Clin North America 2001;21:745-68.
• Samter M, Beers R Jr. Intolerance to aspirin: Clinical studies and consideration of its pathogenesis. Ann Inter Med 1968; 68: 975-83.
• Stevenson DD, Simon RA. Selection of patients for aspirin desensitization treatment. 2006 Oct;118(4):801- 4.
• Mathison DA, Stevenson DD, Simon RA. Precipitating factors in asthma: Aspirin, sulfites, and other drugs and chemicals. Chest 1985;87:50–4.
• Stevenson DD, Simon RA. Lack of cross-reactivity between rofecoxib and aspirin in aspirin-sensitive patients with asthma. J Allergy Clin Immunol 2001;108: 47-51.
• Settipane GA. Aspirin and allergic diseases: A review. Am J Med 1983;74(6A):102–9.
• Berges-Gimeno MP, Simon RA, Stevenson DD. Long term treatment with aspirin desensitization in asthmatic patients with aspirin-exacer-bated respiratory disease. J Allergy Clin Immunol 2003;111:180–6.
• Arm JP, O’Hickey SP, Hawksworth RJ et al: Asthmatic airways have a dispropionate hyperresponsiveness to LTE4, as compared with normal airways, but not to LTC4, LTD4, methacholine and histamine. Am Rev Respir Dis 1990; 142:1112-8.
• Ferreri NR, Howland WC, Stevenson DD, Spiegelberg HL. Release of leukotrienes, prostoglandins, and histamine into nazal secretions of aspirin sensitive asthmatics during reaction to aspirin. Am Rev Resp Dis 1988;137:847-54.
• Juergens UR, Christiansen SC, Stevenson DD, Zuraw BL. Inhibition of monocyte leukotriene B4 production following aspirin desensitization. J Allergy Clin Immunol 1995;96:148-56.
• Stevenson DD, Hankammer MA, Mathison DA, Christiansen SC, Simon RA. Aspirin desensitization treatment of aspirin-sensitive patients with rhinosinusitis-asthma: long-term outcomes.. J Allergy Clin Immunol 1996; 98:751-8.
• Kvedariene V, Bencherioua AM, Messaad D, Godard P, Bousquet J, Demoly P. The accuracy of the diagnosis of suspected paracetamol (acetaminophen) hypersensitivity: results of a single-blinded trial. Clin Exp Allergy 2002;32:1366-9.
• De Paramo BJ, Gancedo SQ, Cuevas M, Camo IP, Martin JA, Cosmes EL. Paracetamol (acetaminophen) hypersensitivity. Ann Allergy Asthma Immunol 2000;85:508-11.
• Quiralte J, Bianco C, Castillo R, Delgado J, Carrillo T. Intolerance to nonsteroidal antiinflammatory drug challenges in 98 patients. J Allergy Clin Immunol 1996;98:678-85.
• Delaney JC. The diagnosis of aspirin idiosyncrasy by analgesic challenge Clin Allergy. 1976;6(2):177-81.
• Bavbek S, Celik G, Ediger D, Mungan D, Demirel YS, Mýsýrlýgil Z. The use of nimesulide in patients with acetylsalicylic acid and nonsteroidal anti- inflammatory drug intolerance. J Asthma 1999;36,657- 63.
• http://www.tihud.org.tr/uploads/content/kongre/5/5.11.pdf
• Pacor ML, Di Lorenzo G, Biasi D, Barbagallo M, Corrocher R. Safety of rofecoxib in subjects with a history of adverse cutaneous reactions to aspirin and/or non-steroidal antiinflammatory drugs. Clin Exp All 2002;32:397-400.
• Sanchez-Borges M, Capriles-Hulett A, Caballero- Fonseca F, Perez CR. Tolerability to new COX-2 inhibitors in NSAID-sensitive patients with cutaneous reactions. Ann Allergy Asthma Immunol 2001;87: 201-4.
• Israel E, Fischer AR, Rosenberg MA, Lilly CM, Callery JC, Shapiro J et al. The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin. Am Rev Respir Dis 1993;148:1447–51.
• Pauls JD, Simon RA, Daffern PJ, Stevenson DD. Lack of effect of the 5-lipoxygenase inhibitor zileuton in blocking oral aspirin challenges in aspirin-sensitive asthmatics. Ann Allergy Asthma Immunol 2000;85:40–5.
• Stevenson DD, Simon RA, Mathison DA, Christiansen SC. Montelukastis only partially effective in inhibiting aspirin response in aspirinsensitive asthmatics. Ann Allergy Asthma Immunol 2000;85:477–82.
• Berges-Gimeno MP, Simon RA, Stevenson DD. The effect of leukotriene modifier drugs on aspirin-induced asthma and rhinitis reactions.Clin Exp Allergy 2002;32:1491-6.
• Menendez R, Venzor J, Ortiz G. Failure of zafirlukast to prevent ibuprofen induced anaphylaxis. Ann Allergy Asthma Immunol 1998;80:225–6.
• Robuschi M, Gambaro G, Setini P, et al. Attenuation of aspirininduced bronchoconstriction by sodium cromoglycate and nedocromil sodium. Am J Respir Crit Care Med 1997;155:1461-4.
• Stevenson DD. Diagnosis, prevention, and treatment of adverse reactionsto aspirin and nonsteroidal anti- inflammatory drugs. J Allergy Clin Immunol 1984;74:617–22.
• Dahlen S, Malmstrom K, Nizankowska E, et al. Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: A randomized, double-blind, placebo-controlled trial. Am J Respir Crit Care Med 2002;165:9–14.