Plateletten zengin fibrinin iyileşme ve rejenerasyon sürecindeki rolü ve ortopedik cerrahide kullanımına dair bir derleme

Year 2019, Volume: 26 Issue: 3, 354 - 361, 01.09.2019

Turan Cihan Dülgeroğlu , Baran Şen

https://doi.org/10.17343/sdutfd.451366

Cited By: 1

Abstract

Platelet-rich fibrin (PRF) is a naturally derived fibrin
scaffold and second-generation platelet concentrate with great potential for
promoting wound healing and the regenerative process via the secretion of
different cytokines and growth factors, enhanced osteoblast adhesion, and
augmentation of collagen protein expression. Given the significance of the
scope of PRF in the field of orthopedic surgery, this study presents an overview
for the role of PRF in the recovery and the regenerative process with emphasis
on its rationale for use and outcome in orthopedic surgery. In conclusion, PRF
offers a new dimension for clinical research with expanded range of potential
applications in orthopedic surgery with a simpler preparation protocol, a
stronger and more stable fibrin polymerization leading to a physiologic
architecture, occurrence of natural clot formation allowing formation of a
flexible and fine fibrin network and a continual and steady release of
cytokines and growth factors, mimicking the requirements of the reparative
tissue and wound healing processes. 

Keywords

Platelet rich fibrin; wound healing; tissue regeneration; growth factors; orthopedic surgery

A review of the role of platelet rich fibrin in healing and regenerative process and its use in orthopaedic surgery

Abstract

References

• 1. Murrell WD, Anz AW, Badsha H, Bennett WF, Boykin RE, Caplan AI. Regenerative treatments to enhance orthopedic surgical outcome. PM R. 2015;7(4 Suppl):41-52. 2. Song Y, Lin K, He S, Wang C, Zhang S, Li D, et al. Nano-biphasic calcium phosphate/polyvinyl alcohol composites with enhanced bioactivity for bone repair via low-temperature three-dimensional printing and loading with platelet-rich fibrin. Int J Nanomedicine. 2018; 13:505-523. 3. Petite H, Viateau V, Bensaïd W, Meunier A, de Pollak C, Bourguignon M, et al. Tissue-engineered bone regeneration. Nat Biotechnol. 2000;18(9):959-963.4. Tampieri A, Sprio S, Sandri M, Valentini F. Mimicking natural bio-mineralization processes: a new tool for osteochondral scaffold development. Trends Biotechnol. 2011;29(10):526-535.5. Demidova-Rice TN, Hamblin MR, Herman IM. Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 1: normal and chronic wounds: biology, causes, and approaches to care. Adv Skin Wound Care. 2012;25(7):304-314.6. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: From pure platelet-rich plasma (P–PRP) to leucocyte- and platelet-rich fibrin. LPRF). Trends Biotechnol. 2009;27(3):158-167.7. Zumstein MA, Bielecki T, Dohan Ehrenfest DM. The future of platelet concentrates in sports medicine: Platelet-rich plasma, platelet-rich fibrin, and the ımpact of scaffolds and cells on the long-term delivery of growth factors. Oper Tech Sports Med 2011;19:190-197.8. Nanditha S, Chandrasekaran B, Muthusamy S, Muthu K. Apprising the diverse facets of Platelet rich fibrin in surgery through a systematic review. Int J Surg. 2017;46:186-194. 9. Alviti F, Gurzì M, Santilli V, Paoloni M, Padua R, Bernetti A, et al. Achilles tendon open surgical treatment with platelet-rich fibrin matrix augmentation: biomechanical evaluation. J Foot Ankle Surg. 2017;56(3):581-585. 10. Anitua E. Plasma rich in growth factors: Preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants 1999;14(4):529-535.11. De Pascale MR, Sommese L, Casamassimi A, Napoli C. Platelet derivatives in regenerative medicine: an update. Transfus Med Rev. 2015;29(1):52-61. 12. Alsousou J, Thompson M, Hulley P, Noble A, Willett K. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature. J Bone Joint Surg (Br) 2009;91(8):987-996.13. Kumar YR, Mohanty S, Verma M, Kaur RR, Bhatia P, Kumar VR, et al. Platelet-rich fibrin: the benefits. Br J Oral Maxillofac Surg. 2016;54(1):57-61. 14. Sheu SY, Wang CH, Pao YH, Fu YT, Liu CH, Yao CH, et al. The effect of platelet-rich fibrin on autologous osteochondral transplantation: An in vivo porcine model. Knee. 2017;24(6):1392-1401. 15. Miron RJ, Zhang Y. Autologous liquid platelet rich fibrin: a novel drug delivery system. Acta Biomater. 2018 May 14. pii: S1742-7061(18)30290-3. doi: 10.1016/j.actbio.2018.05.021. [Epub ahead of print]16. Wu CL, Lee SS, Tsai CH, Lu KH, Zhao JH, Chang YC. Platelet-rich fibrin increases cell attachment, proliferation and collagen-related protein expression of human osteoblasts. Aust Dent J. 2012;57(2):207-212.17. Dohan EDM, Bielecki T, Jimbo R, Barbé G, Del Corso M, Inchingolo F, et al. Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte- and platelet-rich fibrin (L-PRF). Curr Pharm Biotechnol. 2012;13(7):1145-1152.18. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003;83(3):835-870.19. Lieberman JR, Daluiski A, Einhorn TA. The role of growth factors in the repair of the bone. Biology and clinical applications. J Bone Joint Surg Am. 2002; 84-A(6): 1032-1044.20. Anitua E, Sánchez M, Nurden AT, Nurden P, Orive G, Andía I. New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol. 2006; 24(5):227-234. 21. Luginbuehl V, Meinel L, Merkle HP, Gander B. Localized delivery of growth factors for bone repair. Eur J Pharm Biopharm. 2004;58(2):197-208.22. Tabata I I. The importance of drug delivery systems in tissue engineering. Pharm Sci Technolo Today. 2000;3(3):80-89.23. Blair P, Flaumenhaft R. Platelet alpha-granules: basic biology and clinical correlates. Blood Rev 2009;23:177–89.24. Anitua E, Orive G. Endogenous regenerative technology using plasma- and platelet-derived growth factors. J Control Release. 2012;157(3):317-320. 25. Leslie M. Beyond clotting: the powers of platelets. Science 2010;328:562-564.26. Eppley BL, Pietrzak WS, Blanton M. Platelet-rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg 2006;118(6):147-159.27. Nurden AT, Nurden P, Sanchez M, Andia I, Anitua E. Platelets and wound healing. Front Biosci 2008;13:3532-3548.28. Matras H. Die Wirkungen verschiedener Fibrinpraparate auf Kontinuitat-strennungen der Rattenhaut. Osterr Z Stomatol. 1970;67:338-359.29. Rosenthal AR, Harbury C, Egbert PR, Rubenstein E. Use of a platelet-fibrinogenthrombin mixture as a corneal adhesive: Experiments with sutureless lamellar keratoplasty in the rabbit. Invest Ophthalmol 1975;14(11):872-875.30. Knighton DR, Doucette M, Fiegel VD, Ciresi K, Butler E, Austin L. The use of platelet derived wound healing formula in human clinical trials. Prog Clin Biol Res. 1988;266:319-329.31. Whitman DH, Berry RL, Green DM. Platelet gel: An autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg. 1997;55(11):1294-1299.32. Anitua E, Sanchez M, Orive G, Andía I. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials. 2007;28(31):4551-4560.33. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part III: Leucocyte activation: A new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e51-e55.34. Miron RJ, Fujioka-Kobayashi M, Bishara M, Zhang Y, Hernandez M, Choukroun J. Platelet-rich fibrin and soft tissue wound healing: A systematic review. Tissue Eng Part B Rev. 2017;23(1):83-99. 35. Kawase T, Tanaka T. An updated proposal for terminology and classification of platelet-rich fibrin. Regen Ther 2017;7:80-81.36. Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier JB. Three-dimensional architecture and cell composition of a Choukroun’s platelet-rich fibrin clot and membrane. J Periodontol. 2010;81(4):546-555.37. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e37-44. 38. Lundquist R, Dziegiel MH, Agren MS. Bioactivity and stability of endogenous fibrogenic factors in platelet-rich fibrin. Wound Repair Regen. 2008;16(3):356-363.39. Choukroun J, Diss A, Simonpieri A, GirardMO, Schoeffler C, Dohan SL, et al. Plateletrich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:56-60.40. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e45-50.41. Dohan Ehrenfest DM, de Peppo GM, Doglioli P, Sammartino G. Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors 2009;27(1):63-69.42. Kobayashi E, Flückiger L, Fujioka-KobayashiM, Sawada K, Sculean A, Schaller B, et al. Comparative release of growth factors fromPRP, PRF, and advanced-PRF. Clin Oral Investig 2016;20(9):2353-2560.43. Wang M, Li J, Liu J, Lin X, XuW. The comparison of platelet-rich fibrin and platelet-rich plasma in releasing of growth factors and their effects on the proliferation and differentiation of adipose tissue-derived stem cells in vitro. Hua Xi Kou Qiang Yi Xue Za Zhi 2012;30(6):641-644.44. He L, Lin Y, Hu X, Zhang Y, Wu H. A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(5):707-713.45. Kwak HS, Nam J, Lee JH, Kim HJ, Yoo JJ. Meniscal repair in vivo using human chondrocyte-seeded PLGA mesh scaffold pretreated with platelet-rich plasma. J Tissue Eng Regen Med. 2017;11(2):471-480. 46. Ghanaati S, Booms P, Orlowska A, Kubesch A, Lorenz J, Rutkowski J, et al. Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells. J Oral Implantol. 2014;40(6):679-689. 47. Eren G, Kantarcı A, Sculean A, Atilla G. Vascularization after treatment of gingival recession defects with platelet-rich fibrin or connective tissue graft. Clin Oral Investig. 2016;20(8):2045-2053. 48. Kuo TF, Lin MF, Lin YH, Lin YC, Su RJ, Lin HW, et al. Implantation of platelet-rich fibrin and cartilage granules facilitates cartilage repair in the injured rabbit knee: preliminary report. Clinics. 2011;66(10):1835-1838.49. Lucarelli E, Beretta R, Dozza B, Tazzari PL, O'Connel SM, Ricci F, et al. A recently developed bifacial platelet-rich fibrin matrix. Eur Cell Mater. 2010;20:13-23.50. BrehmW, Aklin B, Yamashita T, Rieser F, Trüb T, Jakob RP, et al. Repair of superficial osteochondral defectswith an autologous scaffold-free cartilage construct in a caprine model: implantation method and short-term results. Osteoarthritis Cartilage. 2006;14(12):1214-1226.51. Saluja H, Dehane V, Mahindra U. Platelet-rich fibrin: a second generation platelet concentrate and a new friend of oral andmaxillofacial surgeons. Ann Maxillofac Surg 2011;1(1):53-57.52. Maruyama M, Satake H, Suzuki T, Honma R, Naganuma Y, Takakubo Y, et al. Comparison of the effects of osteochondral autograft transplantation with platelet-rich plasma or platelet-rich fibrin on osteochondral defects in a rabbit model. Am J Sports Med. 2017;45(14):3280-3288. 53. Dietrich F, L Duré G, Klein C, Bampi V, Padoin A, Silva V, et al. Platelet-rich fibrin promotes an accelerated healing of achilles tendon when compared to platelet-rich plasma in rat. World J Plast Surg. 2015;4(2):101-109.54. Zhang S, Matsushita T, Kuroda R, Nishida K, Matsuzaki T, Matsumoto T, et al. Local administration of simvastatin stimulates healing of an avascular meniscus in a rabbit model of a meniscal defect. Am J Sports Med. 2016;44(7):1735-1743.55. Bielecki T, Gazdzik TS, Szczepanski T. Benefit of percutaneous injection of autologous platelet-leukocyte-rich gel in patients with delayed union and nonunion. Eur Surg Res. 2008;40(3):289-296.56. Everts PA, Devilee RJ, Brown Mahoney C, van Erp A, Oosterbos CJ, Stellenboom M, et al. Exogenous application of platelet-leukocyte gel during open subacromial decompression contributes to improved patient outcome. A prospective randomized double-blind study. Eur Surg Res. 2008;40(2):203-210. 57. Everts PA, Devilee RJ, Oosterbos CJ, Mahoney CB, Schattenkerk ME, Knape JT, et al. Autologous platelet gel and fibrin sealant enhance the efficacy of total knee arthroplasty: improved range of motion, decreased length of stay and a reduced incidence of arthrofibrosis. Knee Surg Sports Traumatol Arthrosc. 2007;15(7):888-894. 58. Papalia R, Diaz Balzani L, Torre G, Tirindelli MC, Nobile C, Maffulli N, et al. Intraoperative application of platelet rich fibrin, postoperative injections of PRP or microfracture only for osteochondral lesions of the knee: a five-year retrospective evaluation. J Biol Regul Homeost Agents. 2016;3:41-49.59. Lee HR, Shon OJ, Park SI, Kim HJ, Kim S, Ahn MW, et al. Platelet-rich plasma increases the levels of catabolic molecules and cellular dedifferentiation in the meniscus of a rabbit model. Int J Mol Sci. 2016;17(1):E120. 60. Anitua E, Sanchez M, Nurden AT, Zalduendo M, de la Fuente M, Orive G, et al. Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activities. J Biomed Mater Res A. 2006;77(2):285-293.61. Antuña S, Barco R, Martínez Diez JM, Sánchez Márquez JM. Platelet-rich fibrin in arthroscopic repair of massive rotator cuff tears: a prospective randomized pilot clinical trial. Acta Orthop Belg. 2013;79(1):25-30.