HEART INVOLVEMENT IN COVID-19 INFECTION IN CHILDREN

Year 2021, Volume: 28 Issue: COVİD-19 ÖZEL SAYI, 67 - 72, 01.05.2021

Mahmut Keskin

https://doi.org/10.17343/sdutfd.905829

Cited By: 1

Abstract

ABSTRACT
"Coronavirus Disease 2019 (COVID-19)", which was declared as an epidemic by the World Health Organization (WHO) on March 11, 2020 and named as "Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2)" is generally mild in children. In April 2020, the Pediatric Intensive Care Association in the United Kingdom issued a warning about children presenting with an unusual clinical picture coinciding with toxic shock and atypical Kawasaki disease, including pronounced gastrointestinal symptoms and myocardial involvement. After this date, similar cases began to be reported in various centers in Europe. The World Health Organization defined these cases as pediatric multisystemic inflammatory syndrome (MIS-C) on May 14, 2020. Although it has usually a mild course in children, it can be fatal when COVID-19 causes MIS-C picture. Early diagnosis and treatment is important, especially since cardiac involvement is seen in most patients with MIS-C. In this review, we wanted to evaluation of COVID-19 in terms of cardiac involvement in the light of the literature.

Keywords

MIS-C, COVID-19, Cardiac involvement

ÇOCUKLARDA COVİD-19 ENFEKSİYONUNDA KALP TUTULUMU,

Abstract

ÖZET

Dünya Sağlık Örgütü (DSÖ) tarafından 11 Mart 2020 tarihinde salgın olarak ilan edilen ve “Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2)” olarak isimlendirilen “Coronavirus Disease 2019 (COVID-19)” çocuklarda genellikle hafif seyretmektedir. Nisan 2020'de Birleşik Krallık'taki Pediatrik Yoğun Bakım Derneği, belirgin gastrointestinal semptomları ve miyokardiyal tutulum da dahil olmak üzere toksik şok sendromu ve atipik Kawasaki hastalığı ile örtüşen olağandışı bir klinik tablo ile başvuran çocuklar hakkında bir uyarı yayınladı. Bu tarihten sonra Avrupa’da çeşitli merkezlerde buna benzer vakalar bildirilmeye başlandı. DSÖ 14 Mayıs 2020 tarihinde bu olguları pediatrik multisistemik inflamatuvar sendrom (MIS-C) olarak tanımlamıştır. Çocuklarda hafif seyretmekle birlikte COVID-19 hastalığı MIS-C tablosuna yol açtığında ölümcül olabilmektedir. Özellikle kalp tutulumu MIS-C hastalarının çoğunda görüldüğünden erken tanı ve tedavisi önem arz etmektedir. Bu derlemede COVID-19'u literatür ışığında kardiyak tutulum açısından değerlendirmek istedik.

Keywords

MIS-C, Kardiyak Tutulum, COVID-19

References

• Referens1. Davies P, Evans C, Kanthimathinathan HK, Lillie J, Brierley J, Waters G, et al. Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study. The Lancet Child & Adolescent Health. 2020;4(9):669-77.
• Referans2. Dufort EM, Koumans EH, Chow EJ, Rosenthal EM, Muse A, Rowlands J, et al. Multisystem Inflammatory Syndrome in Children in New York State. N Engl J Med. 2020;383(4):347-58.
• Referans3. Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. New England Journal of Medicine. 2020;383:334-46.
• Referans4. Moraleda C, Serna-Pascual M, Soriano-Arandes A, Simó S, Epalza C, Santos M, et al. Multi-Inflammatory Syndrome in Children related to SARS-CoV-2 in Spain. Clin Infect Dis. 2020;20(60):1-5.
• Referans5. 5. Chiotos K, Bassiri H, Behrens EM, Blatz AM, Chang J, Diorio C, et al. Multisystem Inflammatory Syndrome in Children During the Coronavirus 2019 Pandemic: A Case Series. J Pediatric Infect Dis Soc. 2020;9(3):393-8.
• Referans6. Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020;109(6):1088–95.
• Referans7. Oberweis ML, Codreanu A, Boehm W, Olivier D, Pierron C, Tsobo C, et al. Pediatric life-threatening coronavirus disease 2019 with myocarditis. Pediatr Infect Dis J. 2020;39:e147–9.
• Referans8. Kesici S, Aykan HH, Orhan D, Bayrakci B. Fulminant COVID-19-related myocarditis in an infant. Cardiovascular Flashlight. 2020;e515.
• Referans9. Kohli U, Meinert E, Chong G Tesher M, Jani P. Fulminant myocarditis and atrial fibrillation in child with acute COVID-19. J Electrocardiol 2020;18(20):30571-9.
• Referans10. Fischer Q, Savarin BN, Ducrocq G,Ou P. Case report of an isolated myocarditis due to COVID-19 infection in a paediatric patient. Eurpean Heart Journal. 2020;4:1-5.
• Referans11. Lara D, Young T, Del Toro K, Chan V, Ianiro C, Hunt K et al. Acute Fulminant Myocarditis in a Pediatric Patient With COVID-19 Infection. Pediatrics. 2020;146(2):1-3.
• Referans12. Tseng Y, Herron C, Garcia R, Cashen K. Sustained ventricular tachycardia in a paediatric patient with acute COVID-19 myocarditis. Cardiology in the Young. 2021;8:1-3.
• Referans13. Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al; Chinese Pediatric Novel Coronavirus Study Team. SARS-CoV-2 Infection in Children. N Engl J Med. 2020;382:1663-665.
• Referans14. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al; China Medical Treatment Expert Group for Covid-19. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382:1708-720.
• Referans15. Akhmerov A, Marbán E. COVID-19 and the heart. Circ Res. 2020;126(10):1443-55.
• Referans16. T.C. Sağlık Bakanlığı COVID-19 (SARS-CoV-2 enfeksiyonu) çocuk hasta yönetimi ve tedavi rehberi.
• Referans17. Alsaied T, Tremoulet AH, Burns JC, Saidi A, Dionne A, Lang SM. et al. Review of Cardiac Involvement in Multisystem Inflammatory Syndrome in Children. Circulation. 2021;143(1):78-88.
• Referans18. European Centre for Disease Prevention and Control. Paediatric inflammatory multisystem syndrome and SARS-CoV-2 infection in children. Published May 15, 2020. https://www.ecdc.europa.eu/sites/default/files/ documents/covid-19-risk assessment-paediatric-inflammatory-multisystem-syndrome-15-May-2020.pdf. Accessed June 13, 2020.
• Referans19. Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, et al. American College of Rheumatology Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 and Hyperinflammation in COVID-19. Arthritis & Rheumatology. 2020;72(11):1791-805.
• Referans20. McCrindle BW, Rowley AH, Newburger JW, Burns JC, Bolger AF, Gewitz M, et al. Diagnosis, Treatment, and LongTerm Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation. 2017;135(17):927-99.
• Referans21. Hoang A, Chorath K, Moreira A, Evans M, Burmeister-Morton F, Burmeister F, et al. COVID-19 in 7780 pediatric patients: A systematic review. Ecclinical Medicine 2020;24:100433.
• Referans22. Yaya BCC, Aykac K, Ozsurekci Y, Ceyhan M. Characteristics and Management of Children With COVID-19 in a Tertiary Care Hospital in Turkey. Clinical Pediatrics. 2021;60(3):170-7.
• Referans23. Türk MOK, Akkus CH, Atay G, Erdogan S, Cakir D, Sali E. Therapeutic plasma exchange (TPE) treatment in COVID-19 related Multisystem inflammatory syndrome in children (MIS-C) who admitted withacute abdomen clinic. Jour Umraniye Pediatr.2021; 1(1):14-19.
• Referans24. Kohli U, Lodha R. Cardiac Involvement in Children With COVID-19. Indian Pediatrics. 2020;57(15):936-940.
• Referans25. Ozsurekci Y, Gürlevik S, Kesici S, Akca UK, Oygar PD, Aykac K, et al. Multisystem inflammatory syndrome in children during the COVID-19 pandemic in Turkey: first report from the Eastern Mediterranean. Clinical Rheumatology. https://doi.org/10.1007/s10067-021-05631-9.
• Referans26. Sperotto F, Friedman KG, Son MBF, Pluym CJV, Newburger JW, Dionne A. Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach Eur J Pediatr. 2021; 180(2):307–22.
• Referans27. Canter CE, Simpson KE. Diagnosis and treatment of myocarditis in children in the current era. Circulation. 2014;129(1):115–28.
• Referans28. Caforio ALP, Pankuweit S, Arbustini E, Basso C, Gimeno-Blanes J, Felix SB, et al. European Society of Cardiology Working Group on Myocardial and Pericardial Diseases Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2013;34(33):2636–648.