PAPİLLER TİROİD KARSİNOMUNDA YARARLI BİR BELİRTEÇ OLARAK İNFLAMASYONLA İLİŞKİLİ HEMOGRAM PARAMETRELERİNİN DEĞERLENDİRİLMESİ

Year 2022, Volume: 29 Issue: 4, 611 - 618, 27.12.2022

Mehmet Sözen , Zeynep Cantürk , Alev Selek , Berrin Çetinaslan , Burcu Sevinç , Emre Gezer , Damla Köksalan

https://doi.org/10.17343/sdutfd.1179733

Abstract

Amaç
İnflamasyona bağlı hemogram parametreleri son zamanlarda
kanser hastalarında faydalı bir belirteç olarak
tanımlanmaya başlamıştır. Bu çalışmada, papiller
tiroid kanserli (PTC), malignite potansiyeli belirsiz iyi
diferansiye tiroid tümörü ve foliküler adenomlu (FA)
hastalarda hemogram parametrelerinin karşılaştırılması
amaçlandı.
Gereç ve Yöntem
Çalışmada 287 hastanın verileri analiz edildi. Çalışma
popülasyonu 5 farklı gruba ayrıldı. 1. Grup: kontrol, 2.
grup: FA, 3. grup: WDT-UMP, 4. grup: metastatik olmayan
PTC, 5. grup: metastatik PTC. Ameliyat öncesi
yapılan kan testlerini değerlendirdik.
Bulgular
Ortalama yaş 50 (37-59) idi. Ortalama TSH değeri 1.2
(0.5-2.2) μIU/mL idi. Total tiroidektomi materyalinde
saptanan lezyonun ortalama boyutu 1.7 (1.0-3.0) cm
idi. Grup 3'te beyaz kan hücreleri (WBC), nötrofiller
ve lenfositler grup 4'e göre daha düşüktü (p<0.05).
NLR, kontrol grubu ile tüm gruplarda benzer bulundu
(p=0.173). Kontrol hastalarında MPV istatistiksel
olarak daha yüksek oranda bulundu (p=0.000). MPV
2. grupta, 3. grup ve 4. grupa göre anlamlı derecede
yüksekti (sırasıyla p=0.001, p=0. 016;). RDW, kontrol
grubunda diğer gruplara göre anlamlı derecede düşüktü
(p=0.000). Tümör boyutu ile hemogram parametreleri
arasında korelasyon yoktu.
Sonuç
Tiroid nodülü nedeniyle takip edilen hastalarda düşük
MPV olası malignite açısından şüphe uyandırmalıdır.
Artmış RDW, tiroid nodülü gelişimini öngörmede
faydalı olabilir. Bu kolay erişilebilir, uygun maliyetli
belirteçler, malign nodülleri benign nodüllerden ayırt
etmek için diğer tanı yöntemlerini destekleyebilir.

Keywords

papiller tiroid kanseri, WDT-UMP, foliküler adenom, MPV, RDW

Supporting Institution

yok

Project Number

YOK

Thanks

YOK

EVALUATION OF INFLAMMATION-RELATED HEMOGRAM PARAMETERS AS A USEFUL MARKER IN PAPILLARY THYROID CARCINOMA

Abstract

Objective
Inflammation-related hemogram parameters have
recently started to be defined as a useful marker in
cancer patients. In this study, we aimed to comparison
of hemogram parameters in papillary thyroid cancer
(PTC) patients, well differentiated thyroid tumor
of uncertain malignant potential (WDT-UMP) and
follicular adenoma (FA).
Material and Method
The 287 patients’ data were analyzed in study. Study
subjects were divided into 5 different groups. 1st
group: control, 2nd group: FA, 3rd group: WDT-UMP,
4th group: non-metastatic PTC, 5th group: metastatic
PTC. We evaluated the preoperative blood tests.
Results
The average age was 50 (37-59). The mean TSH
value was 1.2 (0.5-2.2) μIU/mL. The mean size of the
lesion detected in the total thyroidectomy material was
1.7 (1.0-3.0) cm. White blood cells (WBC), neutrophils
and lymphocytes were lower in 3rd group than 4th
group (p<0.05). NLR was found to be similar in all
groups with the control group (p=0.173). MPV was
found to be statistically higher in the control patients
(p=0.000). MPV was significantly higher in 2nd group
compared to 3rd group and 4th group (p=0.001,
p=0.016; respectively). RDW was significantly lower
in the control group compared to all other groups
(p=0.000). There was no correlation between tumor
size and hemogram parameters.
Conclusion
In patients followed up for thyroid nodules, low
MPV should raise a suspicion in terms of possible
malignancy. Increased RDW may be useful in
predicting thyroid nodule development. These easily
accessible, cost-effective markers may support other
diagnostic methods to distinguish malignant from
benign nodules.

Keywords

papillary thyroid cancer, WDT-UMP, follicular adenoma, MPV, RDW

Project Number

YOK

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