KÖK HÜCRELER VE DİŞ HEKİMLİĞİ: LİTERATÜR DERLEMESİ

Year 2019, Volume: 6 Issue: 1, 73 - 81, 01.04.2019

Kübra Gülnur Topsakal , Yasemin Nur Korkmaz

https://doi.org/10.15311/selcukdentj.305565

Abstract

Kök hücreler, hem rejeneratif tıp uygulamalarında
hem de doku rejenerasyonunda kullanılan ve dental dokular da dahil olmak üzere
çok çeşitli doku ve organlardan izole edilen prekürsör hücrelerdir. Hem doku
mühendisliğinde hem de klinik uygulamalarda kullanılan kök hücreler,
odontoblastlardan nöral hücrelere kadar birçok hücreye dönüşebilme yeteneğine
sahiptir. Diş hekimliği alanında yetişkin mezenkimal kök hücreler çeşitli oral
ve maksillofasiyal dokularda tanımlanmıştır; bu da oral dokuların kök
hücrelerden zengin olduğunu ve mukozal hücrelerin indükte pluripotent kök
hücreler gibi genetik olarak yeniden programlanmış hücreler için ideal kaynak
olabileceğini göstermiştir. Ayrıca oral dokuların kök hücreler için yalnızca
bir kaynak değil, aynı zamanda terapötik bir hedef olması da beklenmektedir. Bu
derlemede, diş hekimliği alanındaki klinik kullanılabilirlik ve uygulamalar
açısından çeşitli intra ve ekstraoral doku kökenli kök hücre tiplerine ve
rejeneratif diş hekimliği için uygun kök hücrelere genel bir bakış açısı
sunulmaktadır. 

Keywords

Kök hücre, doku mühendisliği

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