Abstract
Amaç: Multipl Sklerozda (MS), alt üriner sistem fonksiyon bozuklukları oldukça sık görülmektedir. Çalışmamızda, MS hastalarında alt üriner sistem disfonksiyon semptomları ile hastalığın şiddeti, süresi, alt tipi ve lezyon lokalizasyonu arasındaki ilişkiyi göstermeyi amaçladık.
Materyal ve Metod: Son 3 ay içinde nöroloji polikliniğimize başvuran, MS tanılı 42 hastanın demografik özellikleri, MS alt tipi, hastalık süresi, hastalık şiddeti, nörolojik muayeneleri, genişletilmiş özürlülük durum ölçeği (EDSS) puanları, üriner sisteme ait yakınmaları, semptomların süreleri, üriner sistem muayeneleri, fonksiyon testleri (aşırı aktif mesane semptom skoru (OABSS), uluslararası prostat semptom skoru (IPSS)), ürodinamik değerlendirme sonuçları prospektif olarak kaydedildi. İstatistiksel analiz ANOVA, Mann-Whitney U ve non-parametrik Pearson testleri kullanılarak yapıldı. P<0.05 anlamlı olarak kabul edildi.
Bulgular: Çalışmaya 2010 revize Mc Donald kriterlerine göre MS tanısı almış 42 hasta (13 erkek, 29 kadın) dahil edildi. Diyabet, üriner sistem enfeksiyonu ve ürolojik girişim öyküsü olan hastalar çalışmadan dışlandı. Alt üriner sistem semptomlarının varlığı ile yaş, cins, EDSS, MS alt tipi, hastalık süresi arasında anlamlı bir ilişki bulunmadı (p>0,05). İrritatif semptomlar ile cins ve EDSS arasında istatistiksel olarak anlamlı bir farklılık bulunurken (p<0,05), obstrüktif semptomlar konusunda benzer ilişki saptanmadı (p>0,05). İrritatif ve obstrüktif semptomların varlığı ile lezyon lokalizasyonu arasında da istatistiksel olarak anlamlı bir farklılık saptanmadı (p>0,05).
Sonuç: Çalışmamız MS’ te hastalık şiddetinin irritatif üriner semptomlar üzerinde önemli bir belirleyici faktör olduğunu göstermektedir.
Keywords
References
- Referans1 Global Initiative for Chronic Obstructive Lung Disease: Global strategy for diagnosis, management and prevention of Chronic Obstructive Pulmonary Disease updated 2006.
- Referans2 Mannino DM, Watt G, Hole D. The natural history of chronic obstructive pulmonary disease. Eur Respir J 2006; 27:627-43.
- Referans3 Alexander CM, Landsman PB, Teutsch SM, Haffner SM. NCEPdefined metabolic syndrome, diabetes and prevelance of coronary heart disease among NHANES III participants age 50 years and older. Diabetes 2003; 52:1210-1214.
- Referans4 Caso P, Galderisi M, Cicala S, Cioppa C, D'Andrea A, Lagioia G, et al. Association between myocardial right ventricular relaxation time and pulmonary arterial pressure in chronic obstructive lung disease: analysis by pulsed Doppler tissue imaging. J Am Soc Echocardiogr 2001;14:970-976.
- Referans5 Higham MA, Dawson D, Joshi J, Nihoyannopoulos P, Morrell NW. Utility of echocardiography in assessment of pulmonary hypertension secondary to COPD. Eur Respir J 2001;17:350- 355
Abstract
Objective: Lower urinary tract dysfunction (LUTD) are quite commonly seen in Multiple Sclerosis (MS). In this study we aimed to show the relationship between the LUTD symptoms and disease related parameters including the severity, duration, subtypes and the lesion localization of MS.
Material and Method: In a prospective study, we recorded demographic information, MS subtypes, disease duration, disease severity, neurological examinations, scores of Expanded Disability Status Scale (EDSS), lower urinary tract symptoms (LUTS), duration of the symptoms, urinary tract examination, urinary function tests (Overactive Bladder Symptom Score (OABSS), International Prostate Symptom Score (IPSS)), urodynamic evaluation results of 42 MS patients whom admitted to our neurology department during the last 3 months. Statistical analysis was performed by using ANOVA, Mann Whitney-U test and non-parametric Pearson test. p<0.05 was considered statistically significant. Results: 42 patients (13 male, 29 female) who were diagnosed with MS according to the 2010 revised McDonald criteria included in our study while patients with history of diabetes mellitus, urinary tract infections, and urological surgery were excluded. There was no significant relationship between the presence of LUTS, and age, gender, EDSS, MS subtypes, duration of illness (p>0,05). A statistically significant difference was found between the genders, EDSS and irritative symptoms (p<0,05) while no significance was found between obstructive symptoms (p>0,05). There was no statistically significant difference between the localization of the lesion and presence of the irritative and obstructive symptoms (p>0,05).
Conclusion: Our study indicates that, disease severity is an important determinant factor of irritative urinary symptoms in MS patients.
References
- Referans1 Global Initiative for Chronic Obstructive Lung Disease: Global strategy for diagnosis, management and prevention of Chronic Obstructive Pulmonary Disease updated 2006.
- Referans2 Mannino DM, Watt G, Hole D. The natural history of chronic obstructive pulmonary disease. Eur Respir J 2006; 27:627-43.
- Referans3 Alexander CM, Landsman PB, Teutsch SM, Haffner SM. NCEPdefined metabolic syndrome, diabetes and prevelance of coronary heart disease among NHANES III participants age 50 years and older. Diabetes 2003; 52:1210-1214.
- Referans4 Caso P, Galderisi M, Cicala S, Cioppa C, D'Andrea A, Lagioia G, et al. Association between myocardial right ventricular relaxation time and pulmonary arterial pressure in chronic obstructive lung disease: analysis by pulsed Doppler tissue imaging. J Am Soc Echocardiogr 2001;14:970-976.
- Referans5 Higham MA, Dawson D, Joshi J, Nihoyannopoulos P, Morrell NW. Utility of echocardiography in assessment of pulmonary hypertension secondary to COPD. Eur Respir J 2001;17:350- 355
Details
| Journal Section | Articles |
|---|---|
| Authors | |
| Publication Date | December 29, 2016 |
| Submission Date | October 5, 2017 |
| Published in Issue | Year 2016 Volume: 6 Issue: 4 |
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