Batı Nil Virüsü Enfeksiyonuna Sekonder Gelişen Akut Demiyelinizan Polinöropati Olgusu

Year 2019, Volume: 9 Issue: 1, 160 - 163, 20.03.2019

Yonca Ünlübaş Abdulkadir Tunç , Murat Alemdar , Dilcan Kotan

https://doi.org/10.31832/smj.512349

Abstract

Batı Nil virüsü, asemptomatik
bir klinik tablodan ağır ensefalit ve menenjite varan geniş bir klinik
varyasyonla prezente olabilir. Akut demiyelinizan polinöropati birlikteliği çok
nadir bildirilmiştir. 60 yaş
erkek hasta bilinç bozukluğu, kol ve bacaklarda güçsüzlük şikayetleri ile
başvurdu. Kliniği, laboratuvar, beyin omurilik sıvısı ve elektrofizyoloji
bulguları ön planda Guillain Barre sendromu ile uyumlu idi. Ateş, bilinç
bozukluğu ve spastisite gibi atipik bulguların eşlik etmesi nedeniyle detaylı
araştırılan olguda serum BN virüsü IgM testi pozitif bulundu. Türkiye’den
bildirilen ilk olgu olması nedeniyle sunulmaya değer görüldü.

Keywords

Batı Nil virüsü; Guillain Barre sendromu; polinöropati

A Case of Acute Demyelinating Polyneuropathy Secondary to West Nile Virus Infection

Abstract

West Nile virus can lead to a wide range of clinical symptoms from
asymptomatic disease to severe meningitis and encephalitis. The
association of acute demyelinating polyneuropathy is rarely reported. A
60-year-old male patient presented with complaints of impaired consciousness
and weakness in his arms and legs. Clinical
findings, laboratory, cerebrospinal fluid and electrophysiology findings were
consistent with Guillain Barre syndrome. Serum
BN virus IgM test was found to be positive in the patient who was investigated
because of atypical symptoms such as fever, impaired consciousness and spasticity.
Our study was seen worthy to be presented due to the first case reported from
Turkey.

Keywords

West Nile virus; Guillain-Barre syndrome; polyneuropathy

References

• Gubler DJ. The continuing spread of West Nile virus in the western hemisphere. Clin Infect Dis. 2007 Oct 15;45(8):1039-1046.
• Davis LE, DeBiasi R, Goade DE, Haaland KY, Harrington JA, Harnar JB, et al. West Nile virus neuroinvasive disease. Ann Neurol. 2006 Sep;60(3):286-300.
• Loeb M, Hanna S, Nicolle L, Eyles J, Elliott S, Rathbone M, et al. Prognosis after West Nile virus infection. Ann Intern Med. 2008 Aug 19;149(4):232-41.
• Watson JT, Pertel PE, Jones RC, Siston AM, Paul WS, Austin CC, et al. Clinical characteristics and functional outcomes of West Nile Fever. Ann Intern Med. 2004 Sep 7;141(5):360-365.
• Petersen LR, Brault AC, Nasci RS. West Nile virus: review of the literature. JAMA. 2013 Jul 17;310(3):308-315.
• Ahmed S, Libman R, Wesson K, Ahmed F, Einberg K. Guillain-Barre ´ syndrome: an unusual presentation of West Nile virus infection. Neurology. 2000;55: 144-146.
• Alker A. West Nile virus-associated acute flaccid paralysis. BMJ Case Rep. 2015 May 2;2015. pii: bcr2014206480.
• Sejvar JJ, Haddad MB, Tierney BC, Campbell GL, Marfin AA, Van Gerpen JA, et al. Neurologic manifestations and outcome of West Nile virus infection. JAMA. 2003 Jul 23;290(4):511-515.
• Tyler KL, Pape J, Goody RJ, Corkill M, Kleinschmidt-DeMasters BK. CSF findings in 250 patients with serologically confirmed West Nile virus meningitis and encephalitis. Neurology. 2006 Feb 14;66(3):361-365.
• Planitzer CB, Modrof J, Kreil TR. West Nile virus neutralization by US plasma-derived immunoglobulin products. J Infect Dis 2007; 196: 435-440.