Testiküler metastatik olmayan paraganglioma: ilk olgu

Year 2019, Volume: 9 Issue: 2, 361 - 365, 28.06.2019

Samet Şenel , Süleyman Bulut Cüneyt Özden

https://doi.org/10.31832/smj.508403

Abstract

Paragangliomalar
sempatoadrenal nöroendokrin sistemin yayıldığı nöral krest hücrelerinden
gelişen tümörlerdir. Bizim olgumuz da sadece testis
yerleşimli bir paraganglioma olgusu olup, benign vasıftaki literatürdeki ilk
olgudur. 60 yaşında erkek hasta,
ağrısız, sağ skrotal kitle şikayeti ile kliniğimize başvurdu. Preoperatif skrotal
ultrasonda sağ testis orta ve alt polünü tamamen dolduran 40x24
mm boyutlarında kitle lezyonu izlendi. Hastaya sağ radikal orşiektomi
uygulandı. Histopatolojik ve immünohistokimyasal inceleme sonucu testiküler
paraganglioma tanısı konuldu. Ardından yapılan tüm vücut bilgisayarlı tomografi
incelemelerinde herhangi bir şüpheli lenf noduna veya metastatik odağa
rastlanmadı.

Keywords

Paraganglioma, testiküler paraganglioma, testis

Testicular non-metastatic paraganglioma: the first case report

Abstract

Paragangliomas are tumors that develop from neural crest cells spread by
the sympathoadrenergic neuroendocrine system. Our case is a testicular
paraganglioma located exculisively in the testis and it is the first benign case
in the English literature. A 60 years old male
patient presented to our clinic with painless right scrotal mass. Preoperative scrotal ultrasound revealed a vascularized, mass lesion with
two lobules completely filling the middle and lower right testis, measuring
40x24 mm in which anechoic cystic areas were observed. The patient then underwent right radical inguinal orchiectomy. Histopathologically and immunohistochemically, the diagnosis was testicular
paraganglioma. Subsequent whole body-computerized tomography examinations
revealed no suspicious lymph node or metastatic focus.

Keywords

Paraganglioma, testicular paraganglioma, testis

References

• Erickson D, Kudva YC, Ebersold MJ, Thompson GB, Grant CS,vanHeerden JA, Young WF Jr (2001)
• Extra adrenal paragangliomas of the sympathoadrenal neuroendocrine system. In: Lack EE, ed. Atlas of Tumor Pathology, Tumors of the Adrenal Gland and Extra Adrenal Paraganglia. 3rd ed. Bethesda, Md: Armed Forces Institute of Pathology; 1997:269–284.
• Lee JA and Duh QY. Sporadic paraganglioma. World J Surg 2008; 32: 683-687.
• DeVita VT, Hellman S Jr, Rosenborg SA. Cancer Principles and Practice of Oncology. Chapter 29: 841- 847, 2003.
• Eusebi V, Massarelli G (1971) Phaeochromocytoma of the spermatic cord: report of a case. J Pathol 105(4):283–284
• Soejima H, Ogawa O, Nomura Y, Ogata J (1977) Pheochromocytoma of the spermatic cord: a case report. J Urol 118(3):495–496
• Bacchi CE, Schmidt RA, Brandao M, Scapulatempo R, Costa JC, Schmitt FC (1990) Paraganglioma of the spermatic cord. Report of a case with immunohistochemical and ultrastructural studies. Arch PatholLabMed 114(8):899–901
• Mashat F, Meccawi A, Garg S, Christian E (1993) Paraganglioma of the spermatic cord. AnnSaudiMed 13(2):208–210
• Attaran SY, Shakeri S, Sobhani AR (1996) Paraganglioma of the spermatic cord: report of a case. J Urol 155(2):651
• Young IE, Nawroz IM, Aitken RJ (1999) Phaeochromocytoma of the spermatic cord. J Clin Pathol 52(4):305–306
• Abe T, Matsuda H, Shindo J, Nonomura K, Koyanagi T (2000) Ectopic pheochromocytom aarising in the spermatic cord 5 years after removal of bilateral carotid body tumors and adrenal pheochromocytomas. Int J Urol 7(3):110–111
• Garaffa G, Muneer A, Freeman A, AbdelRaheem AM, Ralph DJ, Minhas S, Rees RW (2008) Paraganglioma of the spermatic cord: case report and review of the literature. Sci World J 8:1256–1258
• VirchowsArch. 2010 Nov;457(5):619-22. doi: 10.1007/s00428-010-0966-9. Epub 2010 Sep15. A non-catecholamine-producing sympathetic paraganglioma of the spermatic cord: the importance of performing candidate gene mutation analysis.Alataki D1, Triantafyllidis A, Gaal J, Rodiou C, Vouros J, Papathanasiou A, Papanicolaou A, Rombis V, de Krijger RR.
• Peng Xu, Zhichao Huang, YeqiNian , Mou Peng , Zhiguang Zhou , Lu Yi1 , Yijian Li , Yinhuai Wang Departments of Urology and Endocrine, The Second XiangyaHospital, Central South University, Changsha, Hunan, China. Equal contributors. Case Report Malignant paraganglioma of testis and spermatic cord: a case report. Int J ClinExpMed 2017;10(10):14851-14855
• Makris MC, Koumarelas KC, Mitrousias AS, Psathas GG, Mantzioros A, Sakellariou SP, Ntailiani P, Yettimis E. Endocrinol Diabetes Metab Case Rep. 2014;2014:140055. doi: 10.1530/EDM-14-0055. Epub 2014 Oct 1.
• B. Khoubehi, V. Mishra, M. Ali, H, et al.Adult paratesticula rtumors. BJU International 2002; 90: 707-15.
• Glenner, G. G. andGrimley, P. M.:Tumors of theextra-adrenal paraganglionsystem (includingchemoreceptors). In: Atlas of TumorPathology, 2nd series, fax. 9. Washington, D. C. Armed Forces Institute of Pathology, pp. 81-82, 1974.)
• Cheng L, Leibovich BC, Cheville JC, et al. Paraganglioma of the urinary bladder: can biologic potential be predicted? Cancer. 2000;88:844–852.
• Nistal M, Paniagua R. Non-neoplasticdisease of the testis. InBostwick D, Liang C, editors: Urologic Surgical Pathology, 2nd edn. Edinburgh: MosbyElsevier; 2008. p. 622-3.
• Petersen R, Sesterhenn IA, DavisCJ:UrologicPathology, 3rd edn. Philadelphia: Lippincott Williams & Wilkins;2009. p. 413-4.
• Ruta Gupta, R. Spencer Howell, and Mahul B. Amin (2009) Paratesticular Paraganglioma: A Rare Cause of an Intrascrotal Mass. Archives of Pathology & Laboratory Medicine: May 2009, Vol. 133, No. 5, pp. 811-813.