Evaluation of ventricular repolarization variables in pediatric COVID-19

Year 2021, Volume: 11 Issue: 3, 473 - 478, 22.09.2021

Pınar Dervişoğlu , Taliha Öner , Bahri Elmas , Onur Bircan

https://doi.org/10.31832/smj.942057

Abstract

INTRODUCTION: Although the childhood clinic of COVID-19 is more innocent than adults, its unknown aspects continue to cause concern among pediatricians. One of these unsettling aspects is the cardiovascular system effects. We investigate the role of ventricular repolarization parameters in predicting arrhythmia risk in pediatric COVID-19.
METHODS: Twelve-channel surface electrocardiograms of a total of 166 participants, including children diagnosed with COVID-19 and healthy controls, were analyzed. The QT interval, corrected QT interval, QTc dispersion, Tpeak-Tend, Tp-e dispersion, Tp-e / QT and Tp-e / QTc ratio were calculated. The correlations between ventricular repolarization parameters and laboratory values were examined.
RESULTS: In our study, the COVID-19 patients had a significantly longer Tpeak-Tend (64.51 ± 8.64 and 57.62 ± 7.96; p < 0.001), Tp-e dispersion (21.77 ± 6.4 and 18.01 ± 6.78; p < 0.001), and corrected QT interval (393.18 ± 20.06 and 380 ± 22.3; p < 0.001) duration than the control group. There was a significantly higher Tp-e / QT ratio (0.17 ± 0.02 and 0.15 ± 0.02; p < 0.001), Tp-e / QTc ratio (0.16 ± 0.02 and 0.15 ± 0.02; p < 0.001) in group with COVID-19 than the controls. In addition a positive correlation was found between Tpeak-Tend interval, Tp-e dispersion and white blood cells in the group with SARS CoV2 infection.
DISCUSSION AND CONCLUSION: Evaluating these ventricular repolarization parameters in pediatric SARS CoV2 infection may be useful in predicting the risk of ventricular arrhythmia.

Keywords

COVID-19, child, ventricular repolarization abnormality

COVID-19 tanısı alan çocuklarda ventriküler repolarizasyon değişkenliği

Abstract

GİRİŞ ve AMAÇ: COVID-19'un çocukluklardaki kliniği, yetişkinlere kıyasla daha masum seyretse de bilinmeyen yönleri pediatristler arasında endişe yaratmaya devam ediyor. Bu tedirgin edici yönlerinden biri de kardiyovasküler sistem etkileridir. Biz de bu çalışmada pediyatrik COVID-19'da aritmi riskini tahmin etmede ventriküler repolarizasyon parametrelerinin rolünü araştırmayı amaçladık.
YÖNTEM ve GEREÇLER: COVID-19 teşhisi konan çocuklar ve sağlıklı kontroller dahil olmak üzere toplam 166 katılımcının on iki kanallı yüzey elektrokardiyogramı analiz edildi. Tp-e intervali, Tp-e dispersiyonu, Tp-e / QT oranı, Tp-e / QTc oranı, QT intervali, QTc intervali ve QTc dispersiyonu değerleri hesaplandı. Ventriküler repolarizasyon parametreleri ile laboratuvar değerleri arasındaki korelasyonlar incelendi.
BULGULAR: Çalışmamızda, COVID-19 hastalarında kontrol grubuna göre anlamlı derecede uzamış Tpeak-Tend (64.51 ± 8.64 ve 57.62 ± 7.96; p < 0.001), Tp-e dispersionu (21.77 ± 6.4 and 18.01 ± 6.78; p < 0.001), ve corrected QT intervali (393.18 ± 20.06 ve 380 ± 22.3; p < 0.001) saptandı. COVID-19 olan grupta kontrol grubuna göre anlamlı derecede yüksek Tp-e / QT oranı (0.17 ± 0.02'ye ve 0,15 ± 0,02; p <0,001) ve Tp-e / QTc oranı (0,16 ± 0,02'ye ve 0,15 ± 0,02; p <0,001) vardı. Ayrıca SARS CoV2 enfeksiyonu olan grupta Tpeak-Tend aralığı, Tp-e dispersiyonu ve beyaz kan hücreleri arasında pozitif korelasyon bulundu.
TARTIŞMA ve SONUÇ: Pediyatrik COVID-19 hastalarında bu ventriküler repolarizasyon parametrelerinin değerlendirilmesinin ventriküler aritmi riskini tahmin etmede faydalı olabileceğine inanıyoruz.

Keywords

COVID-19, çocuk, ventriküler repolarizasyon anormalliği

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